No abstract

Due to the higher LET of kilovoltage (kV) radiation, there is potential for an increase in relative biological effectiveness (RBE) of absorbed doses of radiation from kV cone beam computed tomography (CBCT) sources in reference to megavoltage or Co-60 doses. This work develops a method for accurately coupling a Monte Carlo (MC) radiation transport code (PENELOPE) with the damage simulation (MCDS) to predict relative numbers of DNA double strand breaks (DSBs). The MCDS accounts for slowing down of electrons and delta ray production within the cell nucleus; however, determining the spectrum of electrons incident on the cell nucleus from photons interacting in a larger region of tissue is not trivial. PENELOPE simulations were conducted with a novel tally algorithm invoked where electrons incident on a detection material were tracked and both the incident energy and the final deposited dose were recorded. The DSB yield predicted by a set of MCDS runs of monoenergetic electrons was then looked up in a table and weighted by the specific energy of the incident electron. Our results indicate that the RBE for DSB induction is 1.1 for diagnostic x-rays with energies from 80 to 125 kVp. We found no significant change in RBE with depth or filtration. The predicted absolute DSB yields are about three times lower for cells irradiated under anoxic conditions than the yield in cells irradiated under normoxic (5%) or fully aerobic (100%) conditions. However, oxygen concentration has a negligible (± 0.02) effect on the RBE of kV CBCT x-rays.

The HVL and kVp are sufficient for characterizing a kV x-ray source spectrum for accurate dose computation. As these parameters can be easily and accurately measured, they provide for a clinically feasible approach to characterizing a kV energy spectrum to be used for patient specific x-ray dose computations. Furthermore, these results provide experimental validation of our novel hybrid dose computation algorithm.

The fifth generation (5G) wireless networks have to deal with the high data rate and stringent latency requirements due to the massive invasion of connected devices and data-hungry applications.Edge caching is a promising technique to overcome these challenges by prefetching the content closer to the end users at the edge node's local storage. In this paper, we analyze the performance of edge caching 5G networks with the aid of satellite communication systems. Firstly, we investigate the satellite-aided edge caching systems in two promising use cases: a) in dense urban areas, and b) in sparsely populated regions, e.g., rural areas. Secondly, we study the effectiveness of satellite systems via the proposed satellite-aided caching algorithm, which can be used in three configurations: i) mono-beam satellite, ii) multi-beam satellite, and iii) hybrid mode. Thirdly, the proposed caching algorithm is evaluated by using both empirical Zipf-distribution data and the more realistic Movielens dataset. Last but not least, the proposed caching scheme is implemented and tested by our developed demonstrators which allow real-time analysis of the cache hit ratio and cost analysis.

We performed the first comprehensive analysis on the dosimetric properties of an EPID operating at kilovoltage x-ray energies. We characterized the detector performance over a 11-month period. Our results indicate that the imager is a stable and convenient tool for SARRP routine QA tests. We then developed EPID-based tests to perform routine SA-IGRT systems QA tasks, such as verifying constancy of beam quality, energy, output, and profile measurements, relative output factors, and beam targeting.