Quantifying community-wide antimicrobials usage via wastewater-based epidemiology

Holton, Elizabeth; Sims, Natalie; Jagadeesan, Kishore; Standerwick, Richard

doi:10.1016/j.jhazmat.2022.129001

Cited by 23 publications

(5 citation statements)

References 43 publications

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“…A variety of different chemicals or biologicals can act as biomarkers for WBE, and there may be more than one potential biomarker for a given HD. For example, AMR in a community can be evaluated using a range of different types of biomarkers, including antimicrobial chemicals, 41 , 42 antimicrobial-resistant bacteria, 16 and AMR genes. 17 For infectious diseases, the disease-causing organism (e.g., poliovirus 12 , 43 ) or its genomic material (e.g., DNA of Mycobacterium spp.…”

Section: Discussionmentioning

confidence: 99%

A Framework for Public Health Authorities to Evaluate Health Determinants for Wastewater-Based Epidemiology

Eaton

Coxon

Pattis

et al. 2022

Environ Health Perspect

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Background: Wastewater-based epidemiology (WBE) is rapidly developing as a powerful public health tool. It can provide information about a wide range of health determinants (HDs), including community exposure to environmental hazards, trends in consumption of licit and illicit substances, spread of infectious diseases, and general community health. As such, the list of possible candidate HDs for WBE is almost limitless. Consequently, a means to evaluate and prioritize suitable candidates for WBE is useful, particularly for public health authorities, who often face resource constraints. Objectives: We have developed a framework to assist public health authorities to decide what HDs may be appropriate for WBE and what biomarkers could be used. This commentary reflects the experience of the authors, who work at the interface of research and public health implementation. Discussion: To be suitable for WBE, a candidate HD should address a public health or scientific issue that would benefit from better understanding at the population level. For HDs where information on individual exposures or stratification by population subgroups is required, WBE is less suitable. Where other methodologies are already used to monitor the candidate HD, consideration must be given to whether WBE could provide better or complementary information to the current approach. An essential requirement of WBE is a biomarker specific for the candidate HD. A biomarker in this context refers to any human-excreted chemical or biological that could act as an indicator of consumption or exposure to an environmental hazard or of the human health state. Suitable biomarkers should meet several criteria outlined in this commentary, which requires background knowledge for both the biomarker and the HD. An evaluation tree summarizing key considerations for public health authorities when assessing the suitability of candidate HDs for WBE and an example evaluation are presented. https://doi.org/10.1289/EHP11115

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Section: Discussionmentioning

confidence: 99%

A Framework for Public Health Authorities to Evaluate Health Determinants for Wastewater-Based Epidemiology

Eaton

Coxon

Pattis

et al. 2022

Environ Health Perspect

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“…In the last year, little news appeared in the themes of the published investigations. There was a continuity of classic studies on disease-causing organisms (e.g., Dai et al, 2022 ; de Araújo et al, 2022 ; Mercier et al, 2022 ), pharmaceutical use (e.g., Duan et al, 2022 ; Gao et al, 2022a ; Tomsone et al, 2022 ), of illicit and licit drugs (e.g., Wang et al, 2022 ; Chappell et al, 2022 ; Zheng et al, 2022 ), antibiotic-resistant bacteria (e.g., Cai et al, 2022 ; Steenbeek et al, 2022 ; Holton et al, 2022 ), and consumption of sweeteners and steroids ( Li et al, 2022 ; Shimko et al, 2022 ). The novelties were, e.g., the study of the biochemical load in an urban system via WBE, which allowed a holistic understanding of the city's metabolism ( Kasprzyk-Hordern et al, 2022 ).…”

Section: State Of the Art Of Wastewater-based Epidemiology Researchmentioning

confidence: 99%

How has the COVID-19 pandemic impacted wastewater-based epidemiology?

Barcellos,

Barquilha,

Oliveira

et al. 2023

Science of The Total Environment

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Section: Introductionmentioning

confidence: 99%

“…For the quantitative estimation of tobacco use by anabasine or anatabine, the rate at which they are excreted (excretion factor) following the smoking of a cigarette is required. 23 To our knowledge, there is only one study that has estimated the excretion factor of anabasine following cigarette smoking for WBE. 20 That study was based on urine samples from a small sample size of only 10 smokers, probably leading to a high variation in anabasine excretion, although the ratio of anabasine to cotinine concentration remained relative stable.…”

Section: Introductionmentioning

confidence: 99%

Improving Wastewater-Based Tobacco Use Estimates Using Anabasine

Zheng

Gerber

Steadman

et al. 2023

Environ. Sci. Technol.

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In wastewater-based epidemiology (WBE), nicotine metabolites have been used as biomarkers for monitoring tobacco use. Recently, the minor tobacco alkaloids anabasine and anatabine have been suggested as more specific biomarkers for tobacco use since nicotine use can be from both tobacco and non-tobacco sources. This study aimed to provide an in-depth evaluation of the suitability of anabasine and anatabine as WBE biomarkers of tobacco and subsequently estimate their excretion factors for WBE applications. Pooled urine (n = 64) and wastewater samples (n = 277), collected between 2009 and 2019 in Queensland, Australia, were analyzed for nicotine and its metabolites (cotinine and hydroxycotinine), as well as anabasine and anatabine. Anabasine performed as the better biomarker, showing a similar per capita load in pooled urine (2.2 ± 0.3 μg/day/person) and wastewater samples (2.3 ± 0.3 μg/day/person), while the per capita load of anatabine in wastewater was 50% higher than its load in urine. It is estimated that 0.9 μg of anabasine was excreted per cigarette smoked. Triangulation of tobacco sales data and tobacco use estimated from either anabasine or cotinine showed that anabasinebased estimates were 5% higher than sales data, while cotinine-based estimates were between 2 and 28% higher. Our results provided concrete evidence to confirm the suitability of anabasine as a specific biomarker for monitoring tobacco use by WBE.

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Quantifying community-wide antimicrobials usage via wastewater-based epidemiology

Cited by 23 publications

References 43 publications

A Framework for Public Health Authorities to Evaluate Health Determinants for Wastewater-Based Epidemiology

A Framework for Public Health Authorities to Evaluate Health Determinants for Wastewater-Based Epidemiology

How has the COVID-19 pandemic impacted wastewater-based epidemiology?

Improving Wastewater-Based Tobacco Use Estimates Using Anabasine

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