“…Establishing correlations between concentrations in wastewater and human biological samples can help to forge these crucial links. Notably, Eaton et al (2022) developed a framework to help public health authorities decide which HDs may be appropriate for WBE and which biomarkers could be used. This framework consists of an assessment tree that summarizes 1) the requirement for individual-or population-level information, 2) alternative methodologies for monitoring the HD, 3) the availability of a suitable biomarker, and 4) the requirement for changes in biomarker levels to be reflective of changes in the prevalence of the HD.…”