Quantification of tetramethyl-terephthalic acid in rat liver, spleen and urine matrices by liquid–liquid phase extraction and HPLC-photodiode array detection

Baâti, Tarek; Horcajada, Patricia; David, Olivier; Gref, Ruxandra; Couvreur, Patrick; Serre, Christian

doi:10.1016/j.jpba.2012.04.014

Cited by 4 publications

(1 citation statement)

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“…administration of MIL‐100, MIL‐88A, and MIL‐88B_4CH 3 NPs, both the iron and the organic linker concentrations were quantified in several complex biological media, including liver, spleen, and urine. Iron levels were quantified by atomic absorption spectroscopy, whereas the linker concentration was determined by specific extraction and high‐performance liquid chromatography methods …”

Section: Biodistribution Targeting and Pharmacological Efficacymentioning

confidence: 99%

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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Section: Biodistribution Targeting and Pharmacological Efficacymentioning

confidence: 99%