Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

Simón-Yarza, Teresa; Mielcarek, Angelika; Couvreur, Patrick; Serre, Christian

doi:10.1002/adma.201707365

Cited by 485 publications

(326 citation statements)

References 144 publications

(206 reference statements)

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“…Additionally, using endogenous or bioactive molecules as ligands and metal ions with high biocompatibility (such as Fe, Ca, Zn, etc.) as metal nodes to construct functional MOFs is of great benefit to avoid the toxicity of MOFs 5,10,56…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

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536

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Metal–organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during the past decades. Due to the unique features of diverse compositions, facile synthesis, easy surface functionalization, high surface areas, adjustable porosity, and tunable biocompatibility, MOFs have been widely used in hydrogen/methane storage, catalysis, biological imaging and sensing, drug delivery, desalination, gas separation, magnetic and electronic devices, nonlinear optics, water vapor capture, etc. Notably, with the rapid development of synthetic methods and surface functionalization strategies, smart MOF‐based nanocomposites with advanced bio‐related properties have been designed and fabricated to meet the growing demands of MOF materials for biomedical applications. This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis. The prospects and challenges in the field of MOF‐based biomedical materials are also discussed.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

Small

536

376

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“…Prior to entering the in vivo environment, there are also some circumstances that could make particles to aggregate. For instance, the therapeutic agents are often in the format of dry powder that needs dispersion in an electrolyte solution such as 0.9% saline or 5% glucose before administration . However, the LDH nanoparticles quickly form serious aggregates by Bernal stacking during the drying process, and nanoparticles, particularly once dried, cannot be redispersed in the electrolyte media …”

Section: Improved Stability By Surface Engineeringmentioning

confidence: 99%

2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

et al. 2019

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2D nanomaterials represent one of the next‐generation biomaterials with versatile physicochemical advantages that allow for diverse biomedical applications in disease diagnosis, prevention, and treatment. In particular, layered double hydroxide (LDH) nanoparticles, as a typical 2D nanomaterial, have recently shown unprecedented advances in controllable and simplified chemical construction, versatile surface engineering, and comprehensive biological investigation. To realize in vivo biomedical applications, recent efforts have been substantially devoted to a few critical aspects of LDH nanomedicine including nanoparticle stability in physiological environments, accumulation at the disease‐targeted site, selective biological response to the nanoparticle, systematic biosafety examination, integration with multiple diagnostic and therapeutic modalities, and the adjuvant activity and suitability for gene‐based and protein‐based vaccines, which are herein comprehensively reviewed. The challenges and future development strategies of LDH nanomedicine are also discussed toward practical biomedical applications to benefit patients.

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“…[36][37][38] It still remains a key challenge to develop novel NIR-trigged O 2 −• generators to circumvent the tumor hypoxia. [41,42] Porphyrins and porphyrin derivatives as photosensitizers are hydrophobic in nature, which not only cause insufficient selectivity to the site of tumor, but also leads to PS polymerization, reducing the efficacy of PDT and making it very attractive for the assembly structure of organic building units of MOF. [39,40] Compared to the traditional inorganic/organic nanoparticles, MOF offers adjustable structural and chemical composition at the molecular level together with tunable porosity and chemical stability, which can as transport vehicles for the delivery of imaging agents and biologically active molecules realize accurate diagnosis and treatment of tumors.…”

Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC‐UiO) comprised of bacteriochlorin ligand and Hf 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 clusters to address this tricky issue are designed. The resulting DBBC‐UiO enables numerous superoxide anion radical (O 2 −• ) generation via a type I mechanism with a 750 nm NIR‐laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O 2 ) through superoxide dismutase (SOD)‐mediated catalytic reactions under severe hypoxic microenvironment (2% O 2 ), and the partial recycled O 2 enhances O 2 −• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC‐UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

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Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

Cited by 485 publications

References 144 publications

Metal–Organic Frameworks for Biomedical Applications

Metal–Organic Frameworks for Biomedical Applications

2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

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