4.38 The Situation of Metal-Organic Frameworks in Biomedicine ☆

Simón-Yarza, Teresa; Horcajada, Patricia; Serre, Christian

doi:10.1016/b978-0-12-803581-8.09793-9

Cited by 18 publications

(13 citation statements)

References 260 publications

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“…In our previous studies [ 22 ], we have also related efficacy to pharmacokinetic (PK) parameters in particular accumulation in normal skin and the lesion (on the rump). In addition, we intended to compare administration both (i) intravenously, which is the fastest route as AmB nanoparticles are delivered immediately into the blood stream enabling a high bioavailability [ 51 ], and (ii) topically because of the ease of administration and reduced systemic side effects of topical formulations over systemic therapy [ 52 ]. We evaluated both routes, topical and systemic treatment as topical treatment can be used in cases with localized CLwhile systemic treatment is recommended in patients with complex CL [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis

et al. 2020

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Chitosan nanoparticles have gained attention as drug delivery systems (DDS) in the medical field as they are both biodegradable and biocompatible with reported antimicrobial and anti-leishmanial activities. We investigated the application of chitosan nanoparticles as a DDS for the treatment of cutaneous leishmaniasis (CL) by preparing two types of chitosan nanoparticles: positively charged with tripolyphosphate sodium (TPP) and negatively charged with dextran sulphate. Amphotericin B (AmB) was incorporated into these nanoparticles. Both types of AmB-loaded nanoparticles demonstrated in vitro activity against Leishmania major intracellular amastigotes, with similar activity to unencapsulated AmB, but with a significant lower toxicity to KB-cells and red blood cells. In murine models of CL caused by L. major, intravenous administration of AmB-loaded chitosan-TPP nanoparticles (Size = 69 ± 8 nm, Zeta potential = 25.5 ± 1 mV, 5 mg/kg/for 10 days on alternate days) showed a significantly higher efficacy than AmBisome® (10 mg/kg/for 10 days on alternate days) in terms of reduction of lesion size and parasite load (measured by both bioluminescence and qPCR). Poor drug permeation into and through mouse skin, using Franz diffusion cells, showed that AmB-loaded chitosan nanoparticles are not appropriate candidates for topical treatment of CL.

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Section: Discussionmentioning

confidence: 99%

Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis

et al. 2020

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“…Due to their unique structure, record-high surface area, and extremely high porosity, MOFs have a great perspective in various applications. MOF materials are widely studied for gas storage, separation, agriculture, geology, sensing applications, biomedicine, and catalysis [ 1 , 2 , 3 ]. Moreover, MOFs are considered promising materials for biomedical applications including developing more effective therapies [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…MOF materials are widely studied for gas storage, separation, agriculture, geology, sensing applications, biomedicine, and catalysis [ 1 , 2 , 3 ]. Moreover, MOFs are considered promising materials for biomedical applications including developing more effective therapies [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. The ability of MOF to accommodate multiple therapeutic agents, potential antimicrobial features of some MOFs [ 11 , 12 , 13 ] in combination with unique properties of NPs [ 14 ] make nanosized MOF particles better materials for drug delivery and integration in biomedicine [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Abramenko

Deyko

Abkhalimov

et al. 2021

IJMS

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Metal-organic frameworks (MOFs) demonstrate unique properties, which are prospective for drug delivery, catalysis, and gas separation, but their biomedical applications might be limited due to their obscure interactions with the environment and humans. It is important to understand their toxic effect on nature before their wide practical application. In this study, HKUST-1 nanoparticles (Cu-nanoMOF, Cu3(btc)2, btc = benzene-1,3,5-tricarboxylate) were synthesized by the microwave (MW)-assisted ionothermal method and characterized by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques. The embryotoxicity and acute toxicity of HKUST-1 towards embryos and adult zebrafish were investigated. To gain a better understanding of the effects of Cu-MOF particles towards Danio rerio (D. rerio) embryos were exposed to HKUST-1 nanoparticles (NPs) and Cu2+ ions (CuSO4). Cu2+ ions showed a higher toxic effect towards fish compared with Cu-MOF NPs for D. rerio. Both forms of fish were sensitive to the presence of HKUST-1 NPs. Estimated LC50 values were 2.132 mg/L and 1.500 mg/L for zebrafish embryos and adults, respectively. During 96 h of exposure, the release of copper ions in a stock solution and accumulation of copper after 96 h were measured in the internal organs of adult fishes. Uptake examination of the major internal organs did not show any concentration dependency. An increase in the number of copper ions in the test medium was found on the first day of exposure. Toxicity was largely restricted to copper release from HKUST-1 nanomaterials structure into solution.

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“…and as contrast agents . Although MOFs’ bioapplication is quite promising, − a biosafe character must be ensured by a judicious selection of their biofriendly framework composition (i.e., organic linker and metal cation). ,, …”

Section: Introductionmentioning

confidence: 99%

Novel Antibacterial Azelaic Acid BioMOFs

Quaresma

André

Antunes

et al. 2019

Crystal Growth & Design

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The development of metal–organic frameworks (MOFs) for bioapplications has gained great relevance over the last few years, mainly due to their potential as drug carriers and/or imaging agents. Although the bioactive azelaic acid has also been widely used as an antibacterial and anti-inflammatory drug, it presents low solubility, so of utmost importance is the development of more soluble formulations with sustained activity. In this contribution, we prove that new azelaic acid-based metal biomolecule frameworks (BioMOFs) are a viable pathway to achieve this goal. Therefore, five novel MOFs were prepared by a simple, low-cost, and environmentally friendly mechanochemical approach, combining azelaic acid with endogenous cations (i.e., K+, Na+, and Mg2+): [K2(H2AZE)(AZE)] (1), [Na4(HAZE)4] (2), [Na2(AZE)(H2O)] (3), and two different polymorphic forms of [Mg(AZE)(H2O)3] (4) and (5) (where H2AZE - neutral azelaic acid; HAZE - mono-deprotonated azelaic acid; AZE - di-deprotonated azelaic acid). After full structural characterization using single-crystal X-ray diffraction data and other complementary standard solid-state techniques, their thermal and moisture stabilities as well as aqueous solubility were assessed. Finally, their antibacterial activity was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), commonly present on the skin. All MOF materials exhibit good stability and higher solubility than azelaic acid. In addition, BioMOF 1 has shown good antibacterial activity both at pH 5 and 6.5. Thus, 1 has shown to be a promising candidate to further develop new topical formulations of H2AZE.

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4.38 The Situation of Metal-Organic Frameworks in Biomedicine ☆

Cited by 18 publications

References 260 publications

Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis

Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Novel Antibacterial Azelaic Acid BioMOFs

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