Most citrus fruits in Brazil is benefited in juice, generating waste used to extract other valuable by-products. The residue has low added value, being marketed as pellets to feed. Its use in food is an alternative, adding value and contributing nutrients necessary for health. This study aimed to verify the importance of mineral potential for human health residue of citrus fruits, its bioaccessibility and evaluate whether there are differences of these nutrients during the months of harvest. Optimization and validation of a method for the determination of calcium was carried out, iron, zinc and magnesium as an orange residue (pear and hamlin), lemon (taiti and sicilian) and mixtures (orange pear, hamlin and lime tahiti) spectroscopy of flame atomic absorption (FAAS). It was determined the chemical composition of the waste, there was heat treated in these samples and evaluated the bioaccessibility in raw and cooked samples. The optimization was conducted by the experimental design and condition the best mineralization was 6g sample and 8ml of HNO3. All conditions studied in method validation were met. The average levels of calcium, iron, magnesium and zinc were 6827,60μg/g, 116,37μg/g, 915,49μg/g and 7,37μg/g, respectively. Therefore, a portion 100g pomace gives 68.27%, 35.21%, 83.12% and 10% RDI of calcium, magnesium, iron and zinc, respectively, thus the citrus pulp can be considered source Ca, Fe, and Mg. The PCA performed showed that despite the differences in the mineral composition of samples of different vintages, there is a separation of oranges, lemons and mixtures as macronutrient composition. In assessing the chemical composition, the orange residue samples, and lemon mixture had an average 9,3g/100g of moisture, 5,51g/100g of protein, 2,92g/100g ash, 2.87g/100g of lipids, 55g/100g of fiber and total 23,25g/100g of carbohydrates. The phytate fractions were not detected. The iron soluble percentage ranged from 19.36 to 77.33% in the raw samples, and 52.80 to 68.42% in cooked samples. The dialysate iron ranged from 5.59 to 25.26% in raw samples and from 13.06 to 69.06% in baked samples. The soluble Ca was 33.34 to 40.16% in the raw samples and from 38.99 to 55.50% in cooked samples; Ca dialysate in the raw samples was 19.32 to 26.13%, while in cooked the percentage was 14.71 to 21.44%. The soluble Mg ranged from 85.38% in raw samples and boiled at 63.10 to 94.20%, as Mg dialysate ranged from 46.29 to 54.08% in raw samples and 34, 42 to 62.51% in cooked. Cooking increased the Fe solubility in lemon and Fe dialysate in the mix and lemon; increased solubility of Ca but decreased the fraction of Ca dialyzed. In Mg was observed increase in the soluble fraction and dialyzed during cooking, except for the baked orange sample had a decrease in the dialyzed fraction. The evaluation of the physico-chemical characteristics of citrus residue and bioaccessibility of minerals indicating the potential to be used as food or be incorporated into other products, contributing nutrients to the diet and adding value to this b...