Quality of life improves in vasovagal syncope patients after clinical trial enrollment regardless of fainting in follow-up

Ng, Jessica M.Y.; Sheldon, Robert S.; Maxey, Connor; Ritchie, Debbie; Raj, Vidya; Exner, Derek V.; Raj, Satish R.

doi:10.1016/j.autneu.2019.04.001

Cited by 20 publications

(17 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 There is a significant psychosocial impact on quality of life, which is reduced substantially in patients with recurrent syncope. 3,13,14 In particular, Ng et al 3 reported in patients with VVS that the most severely reduced of eight dimensions of quality of life was physical role functioning. Patients feel limited in their physical roles and are significantly more anxious than matched subjects who do not faint.…”

Section: Discussionmentioning

confidence: 99%

Frequency of injuries associated with syncope in the prevention of syncope trials

et al. 2020

Self Cite

View full text Add to dashboard Cite

Aims Syncope can lead to injuries. We determined the frequency, severity, and predictors of injuries due to syncope in cohorts of syncope patients. Methods and results Participants were enrolled in the POST2 (fludrocortisone) and POST4 (midodrine) vasovagal syncope (VVS) randomized trials, and POST3 enrolled patients with bifascicular block and syncope. Injury was defined as minor (bruising, abrasions), moderate (lacerations), and severe (fractures, burns, joint pain), and recorded up to 1 year after enrolment. A total of 459 patients (median 39 years) were analysed. There were 710 faints occurred in 186 patients during a 1-year follow-up. Fully 56/186 (30%) of patients were injured with syncope (12% of overall group). There were 102 injuries associated with the 710 faints (14%), of which 19% were moderate or severe injuries. Neither patient age, sex, nor the presence of prodromal symptoms associated with injury-free survival. Patients with bifascicular block were more prone to injury (relative risk 1.98, P = 0.018). Patients with ≥4 faints in the prior year had more injuries than those with fewer faints (relative risk 2.97, P < 0.0001), but this was due to more frequent syncope, and not more injuries per faint. In VVS patients, pharmacological therapy significantly reduced the likelihood of an injury due to a syncopal spell (relative risk 0.64, P = 0.015). Injury severity did not associate with age, sex, or prior-year syncope frequency. Conclusion Injuries are frequent in syncope patients, but only 4% of injuries were severe. None of age, sex, and prodromal symptoms associate with injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of injuries associated with syncope in the prevention of syncope trials

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…the first Prevention of Syncope Trial (POST1)(30) and(31); iv. the second Prevention of Syncope Trial (POST2)(10,30) and (53)]. Across the 36 studies, 12 distinct generic quality of life instruments were used: the Medical Outcomes Study 36-item Short Form Health Survey (SF-36) (n = 15); SF-36 version 2 (SF-36v2) (n = 1); Medical Outcomes Study 8-item Short Form Health Survey (SF-8) (n = 1); the three-level version of the EQ-5D (EQ-5D-3L) (n = 7); the Pediatric Quality of Life inventory (PedsQL) version 4.0 (n = 3); the RAND 36-item Health Survey (RAND-36) (n = 3); the Quality of Life Systemic Inventory (QLSI) (n = 2); the Sickness Impact Profile (SIP) (n = 1); the World Health Organization Brief Quality of Life Questionnaire (WHOQOL-BREF) (n = 2); the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health (PROMIS-10) (n = 1); the Healthy Days Core Module (CDC HRQOL-14) (n = 1); and the Personal Wellbeing Index-Adult form (PWI-A) (n = 1).…”

mentioning

confidence: 99%

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

Hockin

Heeney

Whitehurst

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

PurposeSyncope (transient loss of consciousness and postural tone) and presyncope are common manifestations of autonomic dysfunction that are usually triggered by orthostasis. The global impact of syncope on quality of life (QoL) is unclear. In this systematic review, we report evidence on the impact of syncope and presyncope on QoL and QoL domains, identify key factors influencing QoL in patients with syncopal disorders, and combine available data to compare QoL between syncopal disorders and to population normative data.MethodsA comprehensive literature search of academic databases (MEDLINE (PubMed), Web of Science, CINAHL, PsycINFO, and Embase) was conducted (February 2021) to identify peer-reviewed publications that evaluated the impact of vasovagal syncope (VVS), postural orthostatic tachycardia syndrome (POTS), or orthostatic hypotension (OH) on QoL. Two team members independently screened records for inclusion and extracted data relevant to the study objectives.ResultsFrom 12,258 unique records identified by the search, 36 studies met the inclusion criteria (VVS: n = 20; POTS: n = 13; VVS and POTS: n = 1; OH: n = 2); 12 distinct QoL instruments were used. Comparisons of QoL scores between patients with syncope/presyncope and a control group were performed in 16 studies; significant QoL impairments in patients with syncope/presyncope were observed in all studies. Increased syncopal event frequency, increased autonomic symptom severity, and the presence of mental health disorders and/or comorbidities were associated with lower QoL scores.ConclusionThis review synthesizes the negative impact of syncope/presyncope on QoL and identifies research priorities to reduce the burden of these debilitating disorders and improve patient QoL.

show abstract

“…Monitoring of rhythm and blood pressure, timely checking immediate ECG, dynamic electrocardiogram, etc. were reported to reduce the risk of syncope (Ng et al, 2019 ; Probst et al, 2020 ; Roca‐Luque et al, 2019 ; Russo et al, 2018 ; Thiruganasambandamoorthy et al, 2020 ). Univariate analysis showed that the prognosis of syncope was related to age ≥60 years old, hypertension, positive troponin T, abnormal electrocardiogram, and coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Etiology, risk factors, and prognosis of patients with syncope: A single‐center analysis

Lin

Feng

Xue

et al. 2021

Noninvasive Electrocardiol

View full text Add to dashboard Cite

Objective To investigate the main causes, risk factors, and prognosis of patients hospitalized with syncope. Methods The patients admitted due to syncope were included. We analyzed the etiology, risk factors, and prognosis of patients with an average follow‐up of 15.3 months. Results High‐risk factors for cardiogenic syncope included age ≥60, male, hypertension, palpitation, troponin T‐positive, abnormal ECG, CHD history, and syncope‐related trauma. Mortality rate was 4.6%, recurrence rate of syncope was 10.5%, and the rehospitalization rate was 8.5%. Univariate analysis showed that prognosis of syncope was related to age ≥60 years old, hypertension, positive troponin T, abnormal electrocardiogram, and coronary heart disease (p < .05). Multivariate Cox proportional hazard analysis showed that age ≥60 years old (p = .021) and high‐sensitivity troponin‐positive (p = .024) were strongly related to the prognosis of syncope. Kaplan–Meier curve showed statistical difference in the survival rate between the groups divided by age ≥60 years (p = .028), hs‐TnT‐positive (p < .001), abnormal ECG (p = .027), and history of CHD (p = .020). Conclusion High‐risk factors for cardiogenic syncope included age ≥60, male, hypertension, palpitation, troponin T‐positive, abnormal ECG, CHD family history, and syncope‐related trauma. Age, hypertension, troponin T‐positive, abnormal ECG, and CHD history were associated with the prognosis of syncope.

show abstract

Quality of life improves in vasovagal syncope patients after clinical trial enrollment regardless of fainting in follow-up

Cited by 20 publications

References 14 publications

Frequency of injuries associated with syncope in the prevention of syncope trials

Frequency of injuries associated with syncope in the prevention of syncope trials

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

Etiology, risk factors, and prognosis of patients with syncope: A single‐center analysis

Contact Info

Product

Resources

About