Frequency of injuries associated with syncope in the prevention of syncope trials

Jorge, Juliana Grael; Pournazari, Payam; Raj, Satish R.; Maxey, Connor; Sheldon, Robert S.

doi:10.1093/europace/euaa246

Cited by 27 publications

(18 citation statements)

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“…Recurrent cases of syncope may reduce the quality of life and promote occupational injury [ 11 ]. Furthermore, they are associated with an increased risk of death and major adverse cardiovascular events [ 51 , 52 ]. Atypical vasovagal syncope (commoner in older adults) and non-neurogenic syncope can often be erroneously misdiagnosed as falls.…”

Section: Discussionmentioning

confidence: 99%

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope, and Falls in Workers

Magnavita

Prinzio

Arnesano

et al. 2021

IJERPH

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Syncope and presyncope episodes that occur during work could affect one’s safety and impair occupational performance. Few data are available regarding the prevalence of these events among workers. The possible role of sleep quality, mental stress, and metabolic disorders in promoting syncope, presyncope, and falls in workers is unknown. In the present study, 741 workers (male 35.4%; mean age 47 ± 11 years), employed at different companies, underwent clinical evaluation and blood tests, and completed questionnaires to assess sleep quality, occupational distress, and mental disorders. The occurrence of syncope, presyncope, and unexplained falls during working life was assessed via an ad hoc interview. The prevalence of syncope, presyncope, and falls of unknown origin was 13.9%, 27.0%, and 10.3%, respectively. The occurrence of syncope was associated with an increased risk of occupational distress (adjusted odds ratio aOR: 1.62, confidence intervals at 95%: 1.05–2.52), low sleep quality (aOR: 1.79 CI 95%: 1.16–2.77), and poor mental health (aOR: 2.43 CI 95%: 1.52–3.87). Presyncope was strongly associated with occupational distress (aOR: 1.77 CI 95%: 1.25–2.49), low sleep quality (aOR: 2.95 CI 95%: 2.08–4.18), and poor mental health (aOR: 2.61 CI 95%: 1.78–3.84), while no significant relationship was found between syncope or presyncope and metabolic syndrome. These results suggest that occupational health promotion interventions aimed at improving sleep quality, reducing stressors, and increasing worker resilience might reduce syncope and presyncope events in the working population.

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Section: Discussionmentioning

confidence: 99%

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope, and Falls in Workers

Magnavita

Prinzio

Arnesano

et al. 2021

IJERPH

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“…Furthermore, the presentation to a doctor is frequently not made in the case of syncope with a benign course; thus, the use of hospital and primary care data inevitably underestimates the real syncope incidence in a population. 6 It is generally accepted that only between 5% and 10% of all patients experiencing syncope seek medical consultation, 3 typically when the outcome was alarming or events recur. 1 The syncope incidence of 2.3% found in the nationwide health care registers is in agreement with the survey-based epidemiological data reporting total lifetime syncope incidence of 20% to 35% 23 , 24 (ie, 10 to 15 times higher than the proportion of Swedish patients diagnosed with syncope by different health care practitioners).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Syncope Associated With Multigenerational Relatives With a History of Syncope

et al. 2021

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IMPORTANCE Reflex syncope is the major cause of transient loss of consciousness, which affects one-third of the population, but effective treatment for individuals with severe syncope is lacking.Better understanding of reflex syncope predisposition may offer new therapeutic solutions.OBJECTIVES To determine the familial risk of syncope in first-, second-, and third-degree relatives of affected individuals and to explore the role of genes and family environment in reflex syncope. DESIGN, SETTING, AND PARTICIPANTSIn this national population-based family cohort study, the Swedish multigeneration register was linked to 3 Swedish nationwide registers: hospital discharge, outpatient care, and primary care registers for the period from 1997 to 2015. Sibling pairs born to Swedish parents between 1948 and 2005 were included. Linkage was also made to half-siblings and cousins. Data analysis was performed from June to October 2020. EXPOSURES Register-based syncope diagnosis among relatives: pairs of twins, siblings, halfsiblings, and cousins. MAIN OUTCOMES AND MEASURESOdds ratios for syncope were calculated for relatives (twins, siblings, half-siblings, and cousins) of individuals who had syncope compared with relatives of individuals without syncope for reference. Sensitivity analysis excluding families with definite nonreflex syncope diagnosis was performed. RESULTSAmong the study population of 2 694 442 participants, 1 381 453 (51.3%) were male, and the median (interquartile range) age was 32 (22-43) years. The study population consisted of 24 020 twins, 1 546 108 siblings, 264 244 half-siblings, and 1 044 546 cousins. In total, 61 861 (2.30%) unique individuals were diagnosed with syncope. Sixty-two percent (38 226) of the syncope-positive individuals were female. The odds ratio (OR) for syncope was 2.39 (95% CI, 1.61-3.53) for twins, 1.81 (95% CI, 1.71-1.91) for siblings, 1.28 (95% CI, 1.20-1.37) for half-siblings, and 1.13 (95% CI, 1.10-1.17) for cousins of individuals with syncope. The OR was highest among male twins at 5.03 (95% CI, 2.57-9.85). The proportion of syncope-positive individuals was consistently higher in women vs men, regardless of degree of relationship (twins: 346 [2.88%] vs 193 [1.61%]; siblings: 22 111 [2.92%] vs 13 419 [1.70%], half-siblings: 4148 [3.44%] vs 2425 [1.93%], cousins: 14 498 [2.87%] vs 9246 [1.72%]). Exclusion of nonreflex syncope diagnoses did not change syncope risk in affected families. CONCLUSIONS AND RELEVANCEIn this Swedish national population-based study, the risk of syncope among relatives of affected individuals was associated with the relationship degree and was strongest in twins and siblings, which suggests that there are genetic components of reflex syncope.Women were more likely to experience syncope independently of family relationship. A better (continued) Key Points Question Is there a familial risk of syncope in first-, second-, and thirddegree relatives of individuals who have had syncope? Findings In this population-based cohort study among adults in Sweden, family ...

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“…Recurrent cases of syncope may reduce the quality of life and promote occupational injury [11]. Furthermore, they are associated with an increased risk of death and major adverse cardiovascular events [51,52]. Atypical vasovagal syncope, which is commoner in older adults, and nonneurogenic syncope can often be erroneously misdiagnosed as falls.…”

Section: Discussionmentioning

confidence: 99%

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Magnavita¹,

Prinzio²,

Arnesano³

et al. 2021

Preprint

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Syncope and presyncope occurring during work can affect safety and impair occupational performance. Few data are available regarding the prevalence of these events among workers. The possible role of sleep quality, mental stress and metabolic disorders in promoting syncope, presyncope and falls in workers is unknown. In the present study, 741 workers (male 35.4%; mean age 47±11 years), employed in different companies, underwent clinical evaluation and blood tests and completed questionnaires to assess sleep quality, occupational distress and mental disorders. The occurrence of syncope, presyncope and unexplained falls during their working life was assessed by an ad hoc interview. The prevalence of syncope, presyncope and falls of unknown origin was 13.9%, 27.0%, and 10.3%, respectively. The occurrence of syncope was associated with an increased risk of occupational distress (adjusted Odds Ratio aOR: 1.62, Confidence Intervals at 95%: 1.05-2.52), low sleep quality (aOR: 1.79 CI 95%: 1.16-2.77) and poor mental health (aOR: 2.43 CI 95%: 1.52-3.87). Presyncope was strongly associated with occupational distress (aOR: 1.77 CI 95%: 1.25-2.49), low sleep quality (aOR: 2.95 CI 95%: 2.08-4.18) and poor mental health (aOR: 2.61 CI 95%: 1.78-3.84), while no significant relationship was found between syncope or presyncope and metabolic syndrome. These results suggest that occupational health promotion interventions aimed at improving sleep quality, reducing stressors and increasing worker resilience might reduce syncope and presyncope events in the working population.

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Frequency of injuries associated with syncope in the prevention of syncope trials

Cited by 27 publications

References 18 publications

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope, and Falls in Workers

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope, and Falls in Workers

Risk Factors for Syncope Associated With Multigenerational Relatives With a History of Syncope

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

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