Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method

Abstract

Ceftriaxone sodium, an antimicrobial agent that plays an important role in clinical practice, is successfully used to treat infections caused by most Gram-positive and Gram-negative organisms. Since there are few rapid analytical methods for ceftriaxone analysis to use in the pharmaceutical routine, the aim of this research was to develop a new method able to quantify this cephalosporin. Therefore, a sensitive, rapid, simple UV spectrophotometric method for the determination and quantification of ceftriaxone sodium was proposed. The UV detector was set at 241 nm. Beer's law obeyed the concentration range of 10–20 µg mL−1. Statistical comparison of the results with a well-established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision. Intra- and interday variability for the method were less than 2% relative standard deviation. The proposed method was applied to the determination of the examined drugs in pharmaceutical formulations and the results demonstrated that the method is equally accurate, precise, and reproducible as the official methods.

New, Green and Miniaturized Analytical Method for Determination of Cefadroxil Monohydrate in Capsules

“…Many studies are carried out on UV-visible spectrophotometric for the identification and quantification of cefadroxil [16][17][18][19][20][21][22], however, in none of the studies has the technique been presented in microplates, which makes the choice of the method safe to be performed and propitious for the continuity of analyzes that contribute to green analytical chemistry. Ultraviolet and visible spectrophotometryis one of the most frequently employed technique in pharmaceutical analysis [23][24][25][26][27][28][29]. Absorption spectrofotometric in the ultraviolet region refers to absorption or reflectance in the visible range (400-800 nm) which directly affects the color of the chemicals used in the tecnique.…”

A Review of Methods for Removal of Ceftriaxone from Wastewater

“…Absorption spectroscopy methods such as ultraviolet (UV) [ 14 , 86 , 87 , 88 , 89 , 90 ], infrared spectroscopy [ 14 , 88 , 90 , 91 , 92 ], spectrofluorimetry [ 14 , 93 ], microbiological methods [ 14 , 94 , 95 ], and capillary zone electrophoresis [ 96 ] have also been used for the analysis of ceftriaxone. When used as an identification technique, UV has limited selectivity because multiple compounds may have the same or similar spectra.…”

Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals

“…For Ceftriaxone, the calibration curve was carried out with the standard of this molecule at concentrations of 70, 50, 20, and 10 μg/ mL. The absorbance measurement wavelength is 241 nm 14 .…”