Quality control and clinical application of two bone imaging99mTc radiopharmaceuticals

Abstract

The radiochemical purity of MDP and HEDP has been determined by means of gel chromatography on Sephadex and thin layer chromatography on plastic foil silica gel. The comparison of the two radiopharmaceuticals shows equal level of complex formation with 99mTc. The biodistribution demonstrated that the application of HEDP allows earlier scanning than MDP. MDP and HEDP show equal effectivity during the clinical investigations. There is no significant difference in the radiochemical purity within six hours after the reconstitution of the freeze-dried kits. HEDP kit demonstrates shorter period of accumulation and equivalent complex formation levels, so it can be used in routine nuclear medicine diagnostics together with MDP kit.

Comparative bone uptake study of alendronate sodium from vaginal suppositories prepared with polyethylene glycol and massa estarinum bases

“…Bisphosphonates are selectively uptake at active bone sites, suppressed the osteoblast and osteoclast mediated bone resorption (1)(2)(3)(4). Alendronate sodium (ALD) is a second generation amino bisphosphonates that selectively inhibits osteoclast-mediated bone resorption, increases bone mineral density and reduces the incidence of vertebral, hip and other fractures (5)(6)(7). Like all bisphosphonates, ALD is poorly absorbed from the gastrointestinal tract, with an oral bioavailability of around 0.9-1.8% (8).…”