Evaluation Bone Uptake of Alendronate Sodium Via Vaginal Route by Gamma Scintigraphy, Vaginal Uptake of Alendronate Sodium

İlem-Özdemir, Derya; Aşıkoğlu, Makbule; Güneri, Tamer; Köseoğlu, Kamil; Özkılıç, Hayal

doi:10.1016/s1773-2247(14)50035-4

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…In radiopharmaceuticals, mostly stannous salts are preferred to use as reducing agents . But in some situations, other reducing agents can be preferred by researchers .…”

Section: Resultsmentioning

confidence: 99%

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Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

İlem-Özdemir

Aşıkoğlu

Özkılıç

et al. 2016

Labelled Comp Radiopharmac

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(99m)Tc-cefotaxime sodium ((99m)Tc-CEF) was developed and standardized under varying conditions of reducing and antioxidant agent concentration, pH, radioactivity dose, and reducing agent type. Labeling studies were performed by changing the selected parameters one by one, and optimum labeling conditions were determined. After observing the conditions for maximum labeling efficiency and stability, lyophilized freeze dry kits were prepared accordingly. Simple method for radiolabeling of CEF with (99m)Tc has been developed and standardized. Labeling efficiency of (99m)Tc-CEF was assessed by both radio thin-layer chromatography and radio high-performance liquid chromatography and found higher than 90%. The labeled compound was found to be stable in saline and human serum up to 24 h. Two different freeze dry kits were developed and evaluated. Based on the data obtained from this study, both products were stable for 6 months with high labeling efficiency. The prepared cold kit was found sterile and pyrogen free. The bacterial infection and sterile inflammation imaging capacity of (99m)Tc-CEF was evaluated. Based on the in vivo studies, (99m)Tc-CEF has higher uptake in infected and inflamed thigh muscle than healthy thigh muscle.

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“…In radiopharmaceuticals, mostly stannous salts are preferred to use as reducing agents . But in some situations, other reducing agents can be preferred by researchers .…”

Section: Resultsmentioning

confidence: 99%

“…In radiopharmaceuticals, mostly stannous salts are preferred to use as reducing agents. [26][27][28][29][30] But in some situations, other reducing agents can be preferred by researchers. 25 The authors labeled CEF by using sodium dithionate as reducing agent.…”

Section: Effect Of Reducing Agent On Labelingmentioning

confidence: 99%

Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

İlem-Özdemir

Aşıkoğlu

Özkılıç

et al. 2016

Labelled Comp Radiopharmac

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“…The formulations delivered the bisphosphonates 10 to 30 times better, compared to oral administration and was able to overcome problems associated with oral administration such as gastric and esophageal reflux and ulceration [ 92 ]. The formulations were potential drugs for the treatment of osteoporosis, Paget’s disease, metastatic cancer of bone, and other related diseases of bone [ 93 , 94 , 95 ]. Ozdemir et al, compared the bone uptake of alendronate sodium from vaginal suppositories prepared with massa estarinum and polyethylene glycol 1500 (PEG) bases.…”

Section: Application Of Bisphosphonatesmentioning

confidence: 99%

Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

Aderibigbe

Popoola

2016

Pharmaceutics

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Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and low intestinal adsorption. These shortcomings have resulted in several researchers developing delivery systems that can enhance their overall therapeutic effectiveness. This review provides a detailed overview of the published studies on delivery systems designed for the delivery of bisphosphonates and the corresponding in vitro/in vivo results.

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“…Microemulsions are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. These systems are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant (5)(6)(7)(8). Microemulsions offer an interesting and potentially quite powerful alternative carrier system for drug delivery because of their high solubilization capacity, transparency, thermodynamic stability, ease of preparation, and high diffusion and absorption rates when compared to solvent without the surfactant system (9).…”

Section: Introductionmentioning

confidence: 99%

Radioactive Permeability Studies of Doxycycline Hyclate from Microemulsion and Solution

İlem-Özdemir¹,

Gündoğdu²,

Ekinci³

et al. 2016

Marmara Pharm J

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Doxycycline Hyclate (DOX) is an antibacterial drug which is member of the second tetracycline group and the absorption of DOX is reduced about 20% in the presence of skimmed milk. Therefore new drug delivery system can be advisable for DOX to reduce the food and drug interaction and improve the bioavailability. The aim of the present study is to prepare a microemulsion system of DOX which could result in reducing in food interaction and an improvement of oral bioavailability by increasing the drug's permeability. For this purposes, DOX was radiolabeled with 99m Tc. radiochemical purity was determined with radioactive thin layer chromatography (rTlc) studies. Tc-DOX-s. Based on the in vitro cell culture studies, this dosage form is a promising formulation as an alternative for oral drug delivery of DOX. Permeability of DOX from

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Evaluation Bone Uptake of Alendronate Sodium Via Vaginal Route by Gamma Scintigraphy, Vaginal Uptake of Alendronate Sodium

Cited by 4 publications

References 21 publications

Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

Radioactive Permeability Studies of Doxycycline Hyclate from Microemulsion and Solution

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Evaluation Bone Uptake of Alendronate Sodium Via Vaginal Route by Gamma Scintigraphy, Vaginal Uptake of Alendronate Sodium

Cited by 4 publications

References 21 publications

Gamma scintigraphy and biodistribution of 99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

Gamma scintigraphy and biodistribution of 99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

Radioactive Permeability Studies of Doxycycline Hyclate from Microemulsion and Solution

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Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation