In vitro incorporation studies of 99mTc–alendronate sodium at different bone cell lines

Liu

et al. 2018

Micro & Nano Letters

A drug delivery system based on ɛ-polylysine-modified titania nanotube (ɛ-PL-TNTs) arrays was prepared. Polylysine on the nanotubes' surface can effectively bind with alendronate, a drug for the treatment of osteoporosis, through chemical bond. The bonds are fairly stable in an acid environment and cannot easily break up in a physiological environment. The ɛ-PL-TNTs increased the amount of drug loading by 9% in weight. The in vitro release profile of alendronate from ɛ-PL-TNTs showed a significant reduced burst release and an extended overall release of more than 15 days.

Section: Resultsmentioning

confidence: 99%

Polylysine‐modified titania nanotube arrays for local drug delivery

Liu

et al. 2018

Micro & Nano Letters

Labelled Comp Radiopharmac

“…In radiopharmaceuticals, mostly stannous salts are preferred to use as reducing agents . But in some situations, other reducing agents can be preferred by researchers .…”

Section: Resultsmentioning

confidence: 99%

Gamma scintigraphy and biodistribution of ^99mTc‐cefotaxime sodium in preclinical models of bacterial infection and sterile inflammation

İlem-Özdemir

Aşıkoğlu

Özkılıç

et al. 2016

Self Cite

(99m)Tc-cefotaxime sodium ((99m)Tc-CEF) was developed and standardized under varying conditions of reducing and antioxidant agent concentration, pH, radioactivity dose, and reducing agent type. Labeling studies were performed by changing the selected parameters one by one, and optimum labeling conditions were determined. After observing the conditions for maximum labeling efficiency and stability, lyophilized freeze dry kits were prepared accordingly. Simple method for radiolabeling of CEF with (99m)Tc has been developed and standardized. Labeling efficiency of (99m)Tc-CEF was assessed by both radio thin-layer chromatography and radio high-performance liquid chromatography and found higher than 90%. The labeled compound was found to be stable in saline and human serum up to 24 h. Two different freeze dry kits were developed and evaluated. Based on the data obtained from this study, both products were stable for 6 months with high labeling efficiency. The prepared cold kit was found sterile and pyrogen free. The bacterial infection and sterile inflammation imaging capacity of (99m)Tc-CEF was evaluated. Based on the in vivo studies, (99m)Tc-CEF has higher uptake in infected and inflamed thigh muscle than healthy thigh muscle.

“…Furthermore, the uptake percentages of 99m Tc-ALD in NCI-H209 and U 2 OS cell lines were found significantly higher. Since 99m Tc-ALD highly uptake in cancer cell line, the authors conclude that radiolabeled ALD may be a promising agent for bone cancer diagnosis [34].…”

Section: In-vitro Evaluation Of Radiopharmaceuticals To Drug To a Spementioning

confidence: 97%

Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies

Özdemir¹,

Ekinci²,

Gündoğdu³

et al. 2016

Int J Med Nano Res