Quality by design (Qbd) assisted development of phytosomal gel of aloe vera extract for topical delivery

Jain, Pooja; Taleuzzaman, Mohamad; Kala, Chandra; Gupta, Dipak Kumar; Ali, Akhter; Aslam, Mohammed

doi:10.1080/08982104.2020.1849279

Cited by 28 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To optimize each parameter, certain sets of formulations were prepared and the one which was showing the best drug loading and encapsulation efficiency was selected for further characterization. Encapsulation efficiency was calculated with the help of below mention formula ( Jain et al, 2020a , Jain et al, 2020b )-

…”

Section: Methodsmentioning

confidence: 99%

“…Periodontal infections have recently become a significant oral health problem in majority of population all over the world ( Eke et al, 2015 ). Periodontitis comprises a group of diseases affecting the supporting tissue of the teeth often causing inflammation and bleeding of gums ( Jain et al, 2020a , Jain et al, 2020b ). The pathogenesis of the disease points towards the involvement of bacterial infections, which is mixed in nature ( Armitage, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

Jain

Garg

Farooq

et al. 2021

Saudi Journal of Biological Sciences

Self Cite

View full text Add to dashboard Cite

PLGA (Lactic- co-glycolic acid) coated chitosan microspheres loaded with hydroxyapatite and doxycycline hyclate complex were developed in the present study for periodontal delivery. A modified single emulsion method was adopted for the development of microspheres. Formulation was optimized on the basis of particle size, drug loading and encapsulation efficiency with the central composite design using 2 3 factorial design. Microspheres were optimized and electron microscopy revealed their spherical shape and porous nature. In-vitro study showed initial burst and then sustained release behavior of the formulation for 14 days. Further, in-vitro antibacterial study performed on E. coli (ATCC-25922) and S. aureus (ATCC-29213) revealed concentration dependent activity. Also, in-vitro cyto-toxicity assessment ensures biocompatibility of the formulation with the fibroblast’s cells. Overall, the quality by design assisted PLGA microspheres, demonstrated the desired attributes and were found suitable for periodontal drug delivery.

show abstract

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

Jain

Garg

Farooq

et al. 2021

Saudi Journal of Biological Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the basis of in-vitro release the researchers found that the phytosomal formulation had better therapeutic potential as compared to conventional. 26 Sushila Rathee and Anjoo Kamboj used Box-Benhken design to optimized and developed anti-diabetic phytosomes. In this study, the prepared phytosomes formulations were optimized using three variables: Lipid (1: 3), temperature (60 0 C) and time (2.5h) .From the results, the researchers concluded that the polyhedral phytosomes preparation can provide a convenient and safe alternative to the conventional dosage form.…”

Section: Phytosomesmentioning

confidence: 99%

Experimental Design: Approaches and Applications in Development of Pharmaceutical Drug Delivery System

Supare

Wadher

Umekar

2021

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Conventionally, all the delivery systems have been prepared by methodology of trial and error concept by manipulating one variable at a Time, but attainment of optimal formulation is not achievable. The systematic approach Design of Experiments (DoE) enables researchers to provide appropriate outline to develop a best optimized delivery system. Optimization techniques using DoE helps to provide effective and economical analytical tools to find the perfect solution for a particular problem. In screening designs, there is large number of screening factors in minimum number of experiments and beneficial to minimize the variables in a desired size therefore further experimentation may be performed easily by using these variables. Experimental designs and optimization techniques are the tools which are systematically used to categorize various types of problems that may influence development of pharmaceutical delivery system. Use of experimental design is the best approach to the screening and optimization of experimental factors. In the present review article we have focused on application of practically applicable experimental designs and optimization techniques for the development of quality and efficacious of pharmaceutical formulations such as, nanoparticles, Phytosomes, microspheres, liposomes, micells, films, nanostructured lipid carriers and tablets and which type of factors to be considered while optimization are also discussed. Keywords: Experimental design, Optimization, Applications, Drug delivery, Phytosomes, Nano delivery System.

show abstract

“…In pharmaceutical nanoformulation development, the application of Quality by Design (QbD) to optimise the relationship between independent and dependent variables using one-way analysis of variance (ANOVA) statistics is good in terms of optimisation, which gives a robust and economic method. With this approach, it is easy to interpret the variable effects and design the experiments [ 19 , 20 , 21 , 22 ]. This research was designed on the basis of existing literature; to date, drug bioavailability has been a concern of research.…”

Section: Introductionmentioning

confidence: 99%

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations

Alam

Shakeel

Foudah

et al. 2022

Gels

View full text Add to dashboard Cite

This research manuscript’s objective was to develop the Punica granatum extract ethosome gel. The use of nanotechnology can improve transdermal drug delivery permeation of its major bioactive compound β-sitosterol. The optimised and developed formulations were further studied in vitro and in vivo. The assessment of the anti-inflammatory activity of the gel was performed in Albino rats. Methanolic extract was prepared and developed into an ethosome suspension and an ethosome gel. To optimise the formulation’s response in terms of particle size (nm) and entrapment efficiency (%), the central composite design (CCD) was used in 22 levels. The effects of factors such as lecithin (%) and ethanol (mL) in nine formulations were observed. Characterisation of ethosome gel was performed and the results showed the particle size (516.4 nm) and mean zeta potential (−45.4 mV). Evaluations of the gel formulation were performed. The results were good in terms of pH (7.1), viscosity (32,158 cps), spreadability (31.55 g cm/s), and no grittiness. In an in vitro study, the percentages of β-sitosterol release of ethosome gel (91.83%), suspension (82.74%), and extracts (68.15%) at 279 nm were recorded. The effects of the formulated gel on formalin-induced oedema in Albino rats showed good results in terms of anti-inflammatory activity. The comparative anti-inflammatory activity of Punica granatum extract and gel showed that the gel action was good for their topical application.

show abstract

Quality by design (Qbd) assisted development of phytosomal gel of aloe vera extract for topical delivery

Cited by 28 publications

References 16 publications

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

Experimental Design: Approaches and Applications in Development of Pharmaceutical Drug Delivery System

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations

Contact Info

Product

Resources

About