Qualitative and Quantitative Performance of<sup>18</sup>F-FDG-PET/MRI versus<sup>18</sup>F-FDG-PET/CT in Patients with Head and Neck Cancer

Partovi, Sasan; Kohan, Andrés; Conejero, J.L. Vercher; Rubbert, Christian; Margevicius, Seunghee; Schluchter, Mark D.; Gaeta, Chiara; Faulhaber, Peter; Robbin, Mark

doi:10.3174/ajnr.a3993

Cited by 63 publications

(40 citation statements)

References 21 publications

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“…Detecting lymph nodes and/or distant metastases of HN cancer is comparable between PET/MRI and PET/CT (k value of interreader agreement of 0.85 and 0.70) [34]. Another study reported that combined PET/MRI using regional PET images increased sensitivity for a suspicious metastatic lymph node resulting in re-classification of stage in two of ten patients [35].…”

Section: Head and Neck Cancermentioning

confidence: 83%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

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Section: Head and Neck Cancermentioning

confidence: 83%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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“…Thus, integrated PET/MRI is expected to allow more accurate local tumor staging as well as lymph node evaluation compared with PET/CT. As most data from the literature have to be considered preliminary, no obvious superiority has been demonstrated until today (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Is integrated 18F-FDG PET/MRI superior to 18F-FDG PET/CT in the differentiation of incidental tracer uptake in the head and neck area?

Schaarschmidt

Gomez

Buchbender³

et al. 2017

Diagn Interv Radiol

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“…Overall, there is a growing consensus that ignoring bones and tissue variability of attenuation coefficients in threeor four-class attenuation maps does not significantly impair lesion detectability and, in general, the diagnostic confidence of PET findings. 26,56 In addition, when PET molecular information is being complemented with MRI functional and morphological information, the number of equivocal findings can be substantially reduced, especially in soft-tissue neoplastic involvements typically encountered in prostate cancer, 160 head and neck cancers, 153,[161][162][163] and gynecologic cancer. 164 However, the presence of artifacts in MRAC maps, particularly metal-susceptibility artifacts, can complicate the interpretation of PET findings 56 and even lead to falsepositive or false-negative findings.…”

Section: B Clinical Perspectives Of Pet/mri Attenuation Correctionmentioning

confidence: 99%

Vision 20/20: Magnetic resonance imaging‐guided attenuation correction in PET/MRI: Challenges, solutions, and opportunities

2016

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Attenuation correction is an essential component of the long chain of data correction techniques required to achieve the full potential of quantitative positron emission tomography (PET) imaging. The development of combined PET/magnetic resonance imaging (MRI) systems mandated the widespread interest in developing novel strategies for deriving accurate attenuation maps with the aim to improve the quantitative accuracy of these emerging hybrid imaging systems. The attenuation map in PET/MRI should ideally be derived from anatomical MR images; however, MRI intensities reflect proton density and relaxation time properties of biological tissues rather than their electron density and photon attenuation properties. Therefore, in contrast to PET/computed tomography, there is a lack of standardized global mapping between the intensities of MRI signal and linear attenuation coefficients at 511 keV. Moreover, in standard MRI sequences, bones and lung tissues do not produce measurable signals owing to their low proton density and short transverse relaxation times. MR images are also inevitably subject to artifacts that degrade their quality, thus compromising their applicability for the task of attenuation correction in PET/MRI. MRI-guided attenuation correction strategies can be classified in three broad categories: (i) segmentation-based approaches, (ii) atlasregistration and machine learning methods, and (iii) emission/transmission-based approaches. This paper summarizes past and current state-of-the-art developments and latest advances in PET/MRI attenuation correction. The advantages and drawbacks of each approach for addressing the challenges of MR-based attenuation correction are comprehensively described. The opportunities brought by both MRI and PET imaging modalities for deriving accurate attenuation maps and improving PET quantification will be elaborated. Future prospects and potential clinical applications of these techniques and their integration in commercial systems will also be discussed. C 2016 American Association of Physicists in Medicine. [http://dx

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Qualitative and Quantitative Performance of¹⁸F-FDG-PET/MRI versus¹⁸F-FDG-PET/CT in Patients with Head and Neck Cancer

Abstract: BACKGROUND AND PURPOSE: MR imaging and PET/CT are integrated in the work-up of head and neck cancer patients. The hybrid imaging technology 18 F-FDG-PET/MR imaging combining morphological and functional information might be attractive in this patient

Cited by 63 publications

References 21 publications

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Is integrated 18F-FDG PET/MRI superior to 18F-FDG PET/CT in the differentiation of incidental tracer uptake in the head and neck area?

Vision 20/20: Magnetic resonance imaging‐guided attenuation correction in PET/MRI: Challenges, solutions, and opportunities

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Qualitative and Quantitative Performance of18F-FDG-PET/MRI versus18F-FDG-PET/CT in Patients with Head and Neck Cancer

Abstract: BACKGROUND AND PURPOSE: MR imaging and PET/CT are integrated in the work-up of head and neck cancer patients. The hybrid imaging technology 18 F-FDG-PET/MR imaging combining morphological and functional information might be attractive in this patient

Cited by 63 publications

References 21 publications

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Is integrated 18F-FDG PET/MRI superior to 18F-FDG PET/CT in the differentiation of incidental tracer uptake in the head and neck area?

Vision 20/20: Magnetic resonance imaging‐guided attenuation correction in PET/MRI: Challenges, solutions, and opportunities

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Qualitative and Quantitative Performance of¹⁸F-FDG-PET/MRI versus¹⁸F-FDG-PET/CT in Patients with Head and Neck Cancer