FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Abstract

The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

Technical Note: Adapting a GE SIGNA PET/MR scanner for radiotherapy

“…The new PET/MR hybrid imaging modality is available from two vendors, and most applications and the majority of the ongoing research is in the area of diagnostics, where PET/MR has been shown to provide an increased diagnostic sensitivity . However, there are advantages to simultaneous collection of PET and MR data for radiotherapy purposes as well, for example, the elimination of image registration, and in the reduction in total scan time and machine occupancy when introducing more focused treatment strategies based on multimodal image information.…”

Current status and future challenges for molecular imaging

“…Multi-modality biomedical imaging has become an important tool to non-invasively assess the metabolic status of a specific biological system [90]. One such example is the clinical application of PET/MRI [91][92][93][94]. In addition, hyperpolarized MRI is an emerging technique in the field of MI that allows for a dramatic increase of the signal available for magnetic resonance spectroscopy experiments in order to overcome the sensitivity limitation of conventional MRI [95][96][97][98][99].…”

Gazi Medical Faculty Nuclear Medicine Department’s Experiences for Usage of PET/MRI Between December 2015-February 2017: Clinical Examples of First 1000 Cases

“…Hasta toleransının zorlanmaması, verilen radyoaktivitenin optimum biçimde değerlendirilebilmesi açısından görüntüleme protokolleri, toplam tüm vücut PET/MR görüntüleme süresi 30-45 dakika arasında olacak şekilde düzenlenmelidir (1). Tüm vücut PET/BT görüntülemesi sonrasında alınacak ek bölgesel PET/MR görüntülerinde ise görüntüleme protokolleri ve seçilecek MR sekansları hastanın kliniğine ve görüntülenecek bölgenin özelliklerine göre belirlenmelidir (1,2).…”