Qualitative Analysis of Oral Lactobacilli Parameters at Different Stages of Human Life Cycle and Different Caries Indices

Relevance. The microbiota of the oral cavity is individual and the consistency of its composition provides a protective function that is regulated by the immune system. Dysbiotic changes in the oral microbiota composition lead to a devastation of local immunity and provide to the disease's development. Herpes virus infection аctivation suppresses the immune response which increases the level of oral mucosa bacteria colonization in particular during the acute course of infectious mononucleosis (IM). Objective: to study the features of the oral microbiome composition and its sensitivity to antibacterial drugs in patients with infectious mononucleosis and acute tonsillitis. Materials and methods. We examined 306 children aged 7 to 236 months. The main group (n = 280) – children with IM. Comparison group (n = 26) – children diagnosed with acute tonsillitis. The main group was divided into two subgroups: subgroup I – 234 children with MI caused by the Epstein-Barr virus (EBV), and subgroup II – 46 children with co-infection with the EBV virus and cytomegalovirus (CMV). The examination was performed according to the treatment protocol: general and biochemical analysis of blood, determination of IgM antibodies to Epstein-Barr virus and cytomegalovirus, bacteriological examination of oropharyngeal mucus, followed by determination of the sensitivity of the identified pathogens to antibacterial drugs. The results. In oral microbiome of children with IM caused by EBV and CMV co-infection pneumococcus dominant. In children with acute tonsillitis, Staphylococcus aureus, S. pyogenes infection, and yeast-like fungi were predominant. S. pyogenes, in children with co-infection, has a high level of resistance to β-lactam antibiotics. Higher levels of antibiotic-resistant strains were found among Enterococcus spp. Isolates, especially in children with EBV-induced MI and co-infection of EBV and CMV. Conclusions. The development of MI is accompanied by microecological dysbiosis of the mucous membranes of the oropharynx and tonsils, which do not provide enough level of colonization resistance, contributing to the spread of antibiotic resistance among resident and transient microbiota.

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The Oropharynx Microbiome Profile of Children With Infectious Mononucleosis Epstein-Barr Viral Etiology

Nadraga

Korniychuk

Klymenko

2021

Med. Sci. of Ukr.

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Antagonistic Activity of Representatives of Oral Biocenosis

et al. 2021

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The aim: Calculate the antagonistic activity of representatives of the oral biotope. Materials and methods: The mathematical techniques used in biotechnology and dentistry. The calculations were carried out on the basis of the research data obtained by the investigators from Ukrainian Medical Stomatological Academy (UMSA) (Poltava). Results: The paper shows that the oral biocenosis is a group of microorganisms that have similar characteristics within the group, but different outside. This may indicate to the relationships between the bacteria, existing within such groups. A graphical demonstration of the associates of the oral biotope with different DMF represents their growth phases depending on the intensity of dental caries. The different slope and phases of the logistic curve of their growth may indicate certain relationships arising between groups of microorganisms. Conclusions: The symbiotic relationships within the oral biocenosis can be manifested by the antagonism, as indicated by the index of antagonistic activity, which in most cases can be calculated. Antagonistic activity can be determined more precisely, for which special techniques have been developed. Antagonistic activity of associates of biocenosis can serve as an indicator of the “conditionally pathogenic - pathogenic” transformation. Data on antagonistic activity can be used in oral hygiene activities and treatment of dental caries to impact the oral microbiocenosis. Data on antagonistic activity may have a predictive value.

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Qualitative Analysis of Oral Lactobacilli Parameters at Different Stages of Human Life Cycle and Different Caries Indices

Cited by 2 publications

References 3 publications

The Oropharynx Microbiome Profile of Children With Infectious Mononucleosis Epstein-Barr Viral Etiology

The Oropharynx Microbiome Profile of Children With Infectious Mononucleosis Epstein-Barr Viral Etiology

Antagonistic Activity of Representatives of Oral Biocenosis

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