The rapid growth of connected devices and multimedia applications intensify the needs of high data rate and energy‐efficient networks. Multitier heterogeneous cloud radio access networks have been presented as a capable candidate for fifth‐generation networks for much higher data rate and energy efficiency (EE) than fourth generation. Therefore, in this paper, we consider the EE maximization in the uplink of a single‐carrier frequency division multiple access–based multitier heterogeneous cloud radio access network. We formulate a joint subchannel assignment, power allocation, and remote radio head association problem for EE maximization. Single‐carrier frequency division multiple access introduces subchannel exclusivity and subchannel adjacency constraints. These constraints, respectively, ensure the allocation of a subchannel to a single user at a time and the allocation of multiple subchannels to a user only if they are adjacent. In addition, we put constraints on each user's minimum data rate and maximum transmit power. Due to the simultaneous consideration of these four constraints, the solution of the formulated problem becomes harder. Therefore, a three‐step algorithm is developed, which solves this problem in an iterative manner. Simulation results verify that our proposed algorithm significantly improve the EE of the network.