Q-T and JT dispersion in the elderly with urban hypothermia

Duraković, Zijad; Mišıgoj-Duraković, Marjeta; Čorović, Naima

doi:10.1016/s0167-5273(01)00498-3

Cited by 14 publications

(18 citation statements)

References 21 publications

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“…Results of QTd were similar to those reported in the medical literature for healthy subjects [13]. JTd parameters in both groups, although similar in the 2 groups, were somewhat lower than previously reported [18][19][20][21].…”

Section: Resultssupporting

confidence: 88%

QT dispersion in amyloidosis due to familial Mediterranean fever

Nussinovitch

et al. 2011

Rheumatol Int

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Cardiac amyloid deposition in FMF may cause increased QT dispersion (QTd), a marker for cardiac arrhythmias. The aim of this study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF) with amyloidosis. Findings on 12-lead electrocardiography were compared between 18 patients with FMF-amyloidosis and 18 age- and sex-matched control subjects. Repolarization and dispersion parameters were computed with designated computer software, and results of the 5 beats were subsequently averaged. There were no statistically significant differences between the groups as to average corrected QT interval length, average QTd interval, average QT corrected dispersion, or QT dispersion ratio. JT dispersion and JT corrected dispersion were also similar in both groups. In conclusion, patients with FMF-amyloidosis seem to have QT and JT dispersion parameters similar to those of healthy subjects. Future research and longer follow-ups should be conducted in order to evaluate the prognostic importance of repolarization dispersion parameters in amyloidosis of FMF.

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Section: Resultssupporting

confidence: 88%

QT dispersion in amyloidosis due to familial Mediterranean fever

Nussinovitch

et al. 2011

Rheumatol Int

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“…23 In addition, several classes of medications prescribed to elderly patients may induce hypothermia by heat loss, such as antipsychotics and antihypertensive alpha-blockers. [23][24][25][26] The high number and category of comorbidities, both clinic (hypertension in 91.4 percent of cases) and psychiatric (dementia syndrome in 71.4 percent of cases reported here) in our group imply constant use of medications, especially antihypertensives and various psychotropic antidepressants and/ or antipsychotics, prescribed for 37.1 percent of the cases in this study. To establish that polypharmacy did indeed represent a predisposing factor of hypothermia in this sample, we should have better assessed the quantity and quality of pharmaceuticals prescribed and administered to patients with hypothermia, compared to those who did not suffer hypothermia during the same period.…”

Section: Discussionmentioning

confidence: 96%

“…18 During septicemia, the hypothalamic fixed pointed shifts downwards, leading to abnormal hypothalamic responses, causing excessive peripheral vasodilation and a drop in the subject's metabolic rate, which in turn leads the body to cool down. 24 It is suggested that this mechanism is activated by increased cytokine response, 3 as well as high levels of TNF-a, interleukin-6, prostaglandins, and thromboxane B2 metabolites. 18,19 Except for one patient, all other elderly (97.1%) in this study progressed to septic shock, and 22.8 percent also experienced respiratory failure.…”

Section: Discussionmentioning

confidence: 99%

Estudo da hipotermia acidental em idosos institucionalizados

Seman¹,

Golim²,

Gorzoni³

2009

Rev. Assoc. Med. Bras.

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Objective. To analyze the prevalence, causes and outcome of hypothermia in institutionalized elderly. MethOds. Prospective study held from January to December, 2004 at Hospital Geriátrico e de Convalescentes Dom Pedro II, with 483 long-term care patients. Hypothermia was diagnosed by esophageal thermometer in all patients with axillary temperature below or equal to 35°C (95°F). Both etiologic diagnosis and complications from hypothermia were noted in clinical and subsidiary examinations. Tests included: ECG, chest radiography, blood count, blood gas analysis, glycemia, metabolites, biochemical blood tests, amylase, kidney and liver functions, urinalysis and serology for HIV, syphilis and hepatitis B. Rewarming was adopted, among other actions in the treatment protocol. Results. Prevalence of hypothermia was 7.2 percent, and the condition was found most often in women (65.7%). The mean age in the sample was 76.4 years. Most patients (77.1%) had high degrees of dependence (Katz index "F" and "G"). Mild hypothermia was identified for most (71.4%) patients. The mortality rate was 62.8 percent, 31.4 percent during hypothermia and 31.4 percent after reversal. Infections were the etiology in all cases: pneumonia (80.0%), urinary tract infection (60.0%), and pressure ulcer (17.1%). There was more than one infection for the same patient in 60 percent of cases. cOnclusiOn. Hypothermia in institutionalized elderly is a serious clinical condition with high rates of mortality. Prevention, early diagnosis and measures of core rewarming improve prognosis.

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“…Moderate hypothermia occurs when temperature falls between 35 and 328C, and severe hypothermia occurs when rectal temperature descends below 328C. 1 Deep hypothermia causes the release of reactive oxygen species and hydroxyl radicals resulting in a destruction of the cell membrane and other components. 2,3 Cell membrane destruction can lead to cell death and also to the production of toxic and reactive aldehydic metabolites.…”

Section: Introductionmentioning

confidence: 99%

Effect of oral vitamin E supplementation on oxidative stress in guinea‐pigs with short‐term hypothermia

Aslan

Meral

2007

Cell Biochemistry & Function

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Effects of oral vitamin E supplementation on blood malondialdehyde (MDA), glutathione (GSH) and vitamin E levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities in acute hypothermia of guinea-pigs were investigated. Thirty male guinea pigs, weighing 500-800 g were randomly divided into one of three experimental groups: A (control, without cooling), B (hypothermic) and C (hypothermic with vitamin E supplementation). The guinea-pigs of group C received daily oral supplementation of 460 mg kg(-1) bw vitamin E for 4 days before inducing hypothermia. Twenty-four hours after the last vitamin E supplementation, the guinea-pigs of the B and C groups were cooled by immersion into cold water (10-12 degrees C), and the control guinea-pigs were immersed into water of body temperature (37 degrees C) up to the neck for 5 min without using any anaesthetic or tranquilizer. Rectal body temperatures of groups were measured and blood samples for biochemical analysis were collected immediately after the cooling. The body temperature, GSH and vitamin E levels and GSH-Px enzyme activity of hypothermic guinea-pigs were lower (p < 0.05), but SOD enzyme activity was not different (p > 0.05) from those of control animals. Although, the body temperature of hypothermic with vitamin E supplementation group was lower (p < 0.05), all other parameters of this group were not different (p > 0.05) from the controls. It was concluded that oral supplementation of vitamin E can alleviate the lipid peroxidation-induced disturbances associated with hypothermia by increasing the serum vitamin E level to normal. However, more studies are needed to prove whether this vitamin can improve quality of life during the cold seasons.

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Q-T and JT dispersion in the elderly with urban hypothermia

Cited by 14 publications

References 21 publications

QT dispersion in amyloidosis due to familial Mediterranean fever

QT dispersion in amyloidosis due to familial Mediterranean fever

Estudo da hipotermia acidental em idosos institucionalizados

Effect of oral vitamin E supplementation on oxidative stress in guinea‐pigs with short‐term hypothermia

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