QT dispersion in amyloidosis due to familial Mediterranean fever

Nussinovitch, Udi; Nussinovitch, Naomi; Nussinovitch, Moshe; Volovitz, Benjamin; Feld, Olga; Ben-Zvi, Ilan; Livneh, Avi

doi:10.1007/s00296-011-1896-9

Cited by 16 publications

(10 citation statements)

References 21 publications

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“…Furthermore, they reported that there is no significant difference in their similar studies of patients with FMF-amyloidosis, colchicine resistant-FMF, and FMF-responsive to colchicine, respectively. [21][22][23][24] Similar to our study, Topal et al 25 did not find any significant difference between the 35 uncomplicated FMF patients and the 38 healthy controls in terms of QTd.…”

Section: Discussionsupporting

confidence: 79%

QT and JT Dispersion in Children With Familial Mediterranean Fever

et al. 2015

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Objectives: This study aims to determine QT dispersion and JT dispersion, and their relationship with conventional echocardiography values in a group of children with familial Mediterranean fever (FMF). Patients and methods:The study included 48 FMF patients (26 males, 22 females, mean age 11.10±3.42 years; range 5 to 18 years) as the FMF patients and 31 healthy children (17 males, 14 females, mean age 9.61±2.83 years; range 5 to 17 years) as the healthy controls. Electrocardiography and conventional echocardiography were performed on the FMF patients and healthy controls. Both groups were evaluated with a standard 12-lead electrocardiography. QT, JT and RR distances were measured in both groups. The corrected QT (QTc) and corrected JT (JTc) were calculated. QTcd and corrected JT dispersion (JTcd) were detected. Results: There was no statistically significant difference between the FMF patients and healthy controls in terms of RR, QT, QTd, QTcd, JT, JTc, JTd, and JTcd measurements and echocardiography parameters. QTc value was higher in the FMF patients than the healthy controls. Conclusion: QTc value indicates increased ventricular sensitivity and is an important marker of cardiovascular mortality. It has an important effect on sudden cardiac death and arrhythmia. Our study results suggest that electrocardiographic monitoring may be useful in patients with FMF.

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Section: Discussionsupporting

confidence: 79%

QT and JT Dispersion in Children With Familial Mediterranean Fever

et al. 2015

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“…However, further evaluation by our group did not reveal any difference in repolarization between FMF patients and healthy controls regardless of the development of amyloidosis [19,20].…”

Section: Introductionmentioning

confidence: 62%

QT interval variability in familial Mediterranean fever: a study in colchicine-responsive and colchicine-resistant patients

et al. 2012

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The association between familial Mediterranean fever (FMF), early atherosclerosis, and electrocardiographic markers for arrhythmias remains controversial. There are conflicting results as to the occurrence of high QT dispersion in FMF. The aim of the present study was to further investigate repolarization dynamics and other repolarization-associated pro-arrhythmogenic markers in FMF patients. To explore repolarization in FMF, patients who responded well to colchicine and patients who had not responded to colchicine, yet were amyloidosis-free, were included. We aimed to evaluate whether increased inflammatory burden, a characteristic of non-responsive patients, was specifically associated with abnormal repolarization. Included in the study were 53 FMF patients (27 colchicine non-responders) and 53 age- and sex-matched control subjects. Electrocardiograms were performed under strict standards. QT variability parameters were computed with custom-made computer software. No significant difference in any of the QT dynamic parameters was found in either FMF group compared with the healthy controls. Mean values of QT variability index, regardless of colchicine response, were similar to previously published results for healthy persons. In conclusion, patients with FMF who are continuously treated with colchicine and have not developed amyloidosis, regardless of their clinical response, have normal QT variability parameters, indicating normal repolarization dynamics and suggesting no increased risk of repolarization-associated cardiac arrhythmias.

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“…Nussinovitchetal published several studies regarding cardiac repolarization abnormalities in FMF patients. In their studies, FMF patients with and without amyloidosis had similar repolarization indices (QT interval, QTc interval and QT dispersion) to those of healthy controls 5,11 . When colchicine resistant FMF patients were compared to healthy controls, they also revealed that cardiac repolarization indices were similar between the two groups 12 .…”

Section: Discussionmentioning

confidence: 99%

“…FMF may cause pericarditis due to serositis and/or cardiac amyloidosis as a part of the systemic disease 3 . Recent studies investigated repolarization abnormalities using markers such as QT dispersion, transmural dispersion of repolarization and P-wave dispersion in FMF patients with and without AAA [4][5][6] . Peak to end interval of T wave is newermarker of cardiac repolarization abnormality, which has been suggested as a better predictor of sudden cardiac death or ventricular tachycardia 7 .…”

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confidence: 99%