Q Fever, Spotted Fever Group, and Typhus Group Rickettsioses Among Hospitalized Febrile Patients in Northern Tanzania

Prabhu, Malavika; Nicholson, William L.; Roche, Aubree J.; Kersh, Gilbert J.; Fitzpatrick, Kelly A.; Oliver, Lindsay D.; Massung, Robert F.; Morrissey, Anne B.; Bartlett, John A.; Onyango, Jecinta J.; Maro, Venance P.; Kinabo, Grace D.; Saganda, Wilbrod; Crump, John A.

doi:10.1093/cid/cir411

Cited by 115 publications

(161 citation statements)

References 45 publications

(66 reference statements)

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“…9 Serum samples were screened for IgG antibodies to hantaviruses using the Hantavirus IgG DxSelect kit. Samples that tested positive or equivocal on the commercial enzyme-linked immunosorbent assay (ELISA) were then tested with an in-house ELISA (using Black Creek Canal virus as antigen) and the recombLine HantaPlus IgG kit to confirm the results of the DxSelect kit.…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence of Seven Zoonotic Pathogens in Pregnant Women from the Caribbean

Wood¹,

Drebot²,

Dewailly³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Section: Methodsmentioning

confidence: 99%

Seroprevalence of Seven Zoonotic Pathogens in Pregnant Women from the Caribbean

Wood¹,

Drebot²,

Dewailly³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…This patient recovered without antibiotics (353), but another MSF case mimicking a hemorrhagic viral fever had a fatal outcome for a South African man (390). In all these cases (353,390,391), the lack of a tick exposure report and the lack of pathognomonic signs such as an inoculation eschar or skin rash have contributed to the lack of any clinical suspicion. This absence of suspicion potentially led to the delayed introduction of a specific antimicrobial therapy.…”

Section: Sub-saharan Africamentioning

confidence: 98%

Update on Tick-Borne Rickettsioses around the World: a Geographic Approach

et al. 2013

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SUMMARY Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group of the genus Rickettsia . These zoonoses are among the oldest known vector-borne diseases. However, in the past 25 years, the scope and importance of the recognized tick-associated rickettsial pathogens have increased dramatically, making this complex of diseases an ideal paradigm for the understanding of emerging and reemerging infections. Several species of tick-borne rickettsiae that were considered nonpathogenic for decades are now associated with human infections, and novel Rickettsia species of undetermined pathogenicity continue to be detected in or isolated from ticks around the world. This remarkable expansion of information has been driven largely by the use of molecular techniques that have facilitated the identification of novel and previously recognized rickettsiae in ticks. New approaches, such as swabbing of eschars to obtain material to be tested by PCR, have emerged in recent years and have played a role in describing emerging tick-borne rickettsioses. Here, we present the current knowledge on tick-borne rickettsiae and rickettsioses using a geographic approach toward the epidemiology of these diseases.

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“…Nevertheless, our observation is similar to a finding in Tanzania where serum antibodies against C. burnetii were detected in 5% of hospitalized patients. 35 As this zoonosis was only recently (2014) classified as a notifiable disease in Brazil, its inclusion in febrile syndromic surveillance programs and a greater availability of diagnostic tests should lead to greater awareness and knowledge about this disease.…”

Section: Discussionmentioning

confidence: 99%

Molecular Identification of Q Fever in Patients with a Suspected Diagnosis of Dengue in Brazil in 2013–2014

Mares-Guia¹,

Rozental²,

Guterres³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Q fever is an important cause of undifferentiated fever that is rarely recognized or reported in Brazil. The objective of this study was to look for the presence of Coxiella burnetii during a dengue fever outbreak in the municipality of Itaboraí, Rio de Janeiro, Brazil, where this bacterium had previously infected humans and domesticated animals. Blood samples from clinically suspected dengue fever patients were tested by polymerase chain reaction (PCR) for C. burnetii; the DNA was detected in nine (3.3%) of 272 patients. One was coinfected with dengue virus, which was also detected in another 166 (61.3%) patients. The nucleotide sequence of PCR amplification and DNA sequencing of the IS1111 transposase elements in the genome of C. burnetii exhibited 99% identity with the sequence in GenBank. The detection of C. burnetii in patients suspected of dengue fever indicates that awareness and knowledge of Q fever should be strengthened and that this bacterium is present in Brazil. Finally, because a negative molecular result does not completely rule out the diagnosis of Q fever and the serological assay based on seroconversion was not available, the actual number of this zoonosis is likely to be much higher than that reported in this study.

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Q Fever, Spotted Fever Group, and Typhus Group Rickettsioses Among Hospitalized Febrile Patients in Northern Tanzania

Abstract: Despite being common causes of febrile illness in northern Tanzania, Q fever and SFGR are not diagnosed or managed with targeted antimicrobials. C. burnetii does not appear to be an HIV-associated co-infection.

Cited by 115 publications

References 45 publications

Seroprevalence of Seven Zoonotic Pathogens in Pregnant Women from the Caribbean

Seroprevalence of Seven Zoonotic Pathogens in Pregnant Women from the Caribbean

Update on Tick-Borne Rickettsioses around the World: a Geographic Approach

Molecular Identification of Q Fever in Patients with a Suspected Diagnosis of Dengue in Brazil in 2013–2014

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