Pyrexia with dermatitis in dairy cows

Breukink, HJ; Gruys, E; Holzhauer, Cathryn Glanton; Westenbroek, AC

doi:10.1136/vr.103.10.221

Cited by 17 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Um exame mais acurado na literatura mais remota revela que enfermidades semelhantes têm sido descritas, sem suspeita da causa (Breukink et al 1978, Matthews & Shreeve 1978 ou atribuídas a micotoxicoses (Albright et al 1964, Petrie 1977, infecção por fungo (Andrews et al 1983), infecção geral (Turner et al 1978), processos alérgicos e até ingestão de silagem (Thomas 1978, 1979, Holden 1980. Saunders et al (2000), aparentemente estudando o mesmo surto de mortandade em bovinos investigado por Pollak et al (1998), em que foi levantada a suspeita de ter sido causada pela alimentação com polpa cítrica, dizem que o princípio tóxico é desconhecido, mas como na intoxicação pela ervilhaca, o caráter da inflamação nos órgãos sugere reação de hipersensibilidade do tipo IV; a lectina estaria atuando como imuno-estimulante.…”

Section: Introdução Introduçãounclassified

Experimentos com a polpa cítrica em ovinos e coelhos

2001

View full text Add to dashboard Cite

Citrus pulp was fed to sheep and rabbits in high doses and during long periods, in order to find an experimental model. The citrus pulp used in the experiments in sheep was the same used by a cattle breeder in Lorena, State of São Paulo, who lost out of a total of 56 lactating cows during a period of a few weeks 5 animals by a disease characterized histologically by granulomatous lesions. The 4 sheep used in the experiments received 800g/day/animal of this citrus pulp during 10 to 11 months. They were euthanized at the end of the experiment. None of the sheep showed the clinical-pathological picture of citrus pulp poisoning seen in cattle or other alterations. In the experiments in rabbits citrus pulp of two procedures were used. In one series (6 rabbits) the same citrus pulp was given as used in the experiments in sheep; in the other series (6 rabbits) the citrus pulp used in experiments in dogs, in which it caused granulomatous lesions, was given. The rabbits of the first series ingested an average of 51.5 g/day/animal; the rabbits of the second series ingested an average of 35.2 g/kg/animal of the citrus pulp. The rabbits were euthanized 2, 3, 6 and 12 months after the beginning of the experiments. None of the rabbits showed the clinical and pathological picture of citrus pulp poisoning or any other alterations.INDEX TERMS: Experimental citrus pulp poisoning, sheep, rabbits.

show abstract

Section: Introdução Introduçãounclassified

Experimentos com a polpa cítrica em ovinos e coelhos

2001

View full text Add to dashboard Cite

show abstract

“…The clinical signs and histopathological lesions in both cows resembled those previously described in dairy cows affected by the syndrome (5-10). Although its etiology is still unclear, citrinin mycotoxicosis (5,11) or di-ureido isobutane (DUIB) poisoning (6) has been suggested as a potential cause. Toxic causes were excluded in the present cases.…”

mentioning

confidence: 99%

Potential Pathogenetic Role of Bovine Herpesvirus 4 in Two Dairy Cows with Dermatitis-Pyrexia-Hemorrhagic Syndrome

et al. 2015

View full text Add to dashboard Cite

c Dermatitis, pyrexia, and hemorrhagic syndrome (DPHS) is a rare bovine syndrome of unclear etiology. We describe two DPHS cases, the first to occur in Italy, with clinicopathological findings suggesting a potential pathogenetic role of bovine herpesvirus-4 (BoHV-4). CASE REPORT Two Italian Holstein-Friesian cows, 5 and 6 years old, from the same herd were referred to the Teaching Hospital of the Department of Veterinary Science of Turin University because of acute onset of pyrexia, pruritus, and skin lesions. One animal (cow A) was referred 1 week after the onset of clinical signs and displayed forced decubitus; the other animal (cow B) was referred 36 h after the onset of clinical signs. Both animals were anorectic, showed signs of depressed mental status, with decreased/absent milk production, pyrexia (rectal temperature, Ͼ41.0°C), and disseminated pruritic papulocrustous dermatitis of the head, neck, tail, perineum, and udder ( Fig. 1A to C). In addition, cow B presented hemorrhagic suffusion of the vulvar mucosal membrane (Fig. 1D) and bloody diarrhea.In cow A, the complete blood cell count (ADVIA 120 hematology system; Bayer) was unremarkable. In cow B, the hematological parameters were significantly altered: severe leukopenia (white blood cell count, 2,680 cells/ml [reference range, 6,200 to 13,600 cells/ml]), lymphopenia (2,004 cells/ml [reference range, 4,000 to 9,800 cells/ ml]), neutropenia (390 cells/ml [reference range, 1,100 to 3,600 cells/ ml]), monocytopenia (160 cells/ml [reference range, 200 to 1,300 cells/ml]), and thrombocytopenia (190, Serological investigations showed antibody (Ab) titers of 3ϩ and 2ϩ for bovine herpesvirus 4 (BoHV-4) (PrimaCheck bovine respiratory syncytial virus [BRSV] Ab; Agrolabo) in cow A and cow B, respectively. No serum antibodies for BoHV-1, bovine BoHV-2, BoHV-5, bovine virus diarrhea/mucosal disease (BVD/ MD), parainfluenza 3 virus (PI3), BRSV, pseudorabies virus (PrV), Mycoplasma spp., or Mycobacterium avium subsp. paratuberculosis were detected in either animal.Parasitological and mycological investigations of the skin and hair samples were negative in both animals.Cow A was euthanized for animal welfare reasons; cow B died spontaneously after 8 days despite supportive treatment. Gross examination revealed multifocal whitish areas involving the renal cortex in both animals; subcutaneous hematomas and severe multifocal hemorrhages of the intercostal muscles were noted in cow B (Fig. 2A). The major histopathological findings for both animals were cutaneous leukocytoclastic vasculitis (Fig. 2B) associated with superficial and deep dermatitis, hyperkeratosis (Fig. 2C), and subepidermal separations and ulcerations, in addition to chronic interstitial nephritis associated with vasculitis (Fig. 2D). Severe and diffuse splenic depletion associated with histiocytic giant cells and neutrophilic infiltrates and minimal multifocal interstitial pneumonia were observed in cow B.Bacteriological examination and indirect immunofluorescence testing (IIFT) for anti-bovine IgG in s...

show abstract

“…1 None of the approximately cytic/plasmacytic/eosinophilic/multinucleated giant 50 cattle that developed the syndrome in 1978 in Britcell infiltration causing enlargement and architectural ain received DUIB. 10 disruption of the many infiltrated organs.…”

mentioning

confidence: 99%

“…The interval between observed illness and death with diureido-isobutane (DUIB) in the ration. 1 The is usually 10-20 days (range = 3 days to 5 weeks).…”

mentioning

confidence: 99%

Hairy Vetch (Vicia VillosaRoth) Poisoning in Cattle: Update and Experimental Induction of Disease

1992

View full text Add to dashboard Cite

Abstract. Hairy vetch poisoning (vetch-associated disease) of cattle is a generalized disease characterized pathologically by infiltration of skin and many internal organs by monocytes, lymphocytes, plasma cells, and often eosinophils and multinucleated giant cells and clinically by dermatitis, pruritis, often diarrhea, wasting, and high mortality. The disease was experimentally reproduced in an adult Angus female that had recovered from the natural disease 1 year earlier. She developed dermatitis on the 11th day of vetch feeding, and despite withdrawal from the vetch diet on the 12th day, death occurred 24 days after first day of vetch feeding. The cow developed lymphocytosis and hyperproteinemia. The results of other hematologic evaluations, blood chemical profiles, urinalysis, and cutaneous hypersensitivity tests using vetch lectin were normal. Lymphocyte blastogenesis studies with vetch lectin were not interpretable. Necropsy revealed gross lesions characteristic of the disease in the skin, heart, kidney, adrenal, and lymphoid tissues. Microscopically there was typical cellular infiltration in those organs and in the thyroid, liver, pancreas, salivary and mammary glands, urinary bladder, corpus luteum, and cerebral meninges. Cutaneous apocrine gland necrosis was present. The inflammatory reaction has qualities of a type-IV hypersensitivity reaction. Hypersensitivity may occur when constituents of the ingested plant are absorbed and act as antigens that sensitize lymphocytes and evoke the multisystemic granulomatous inflammatory response that characterizes the disease. Alternatively, vetch lectin may directly activate T lymphocytes to initiate the cellular response. Vetch-like diseases have been associated with a variety of diets that did not contain hairy vetch. The gross and histopathologic lesions of the vetch-associated and the vetch-like diseases are not mimicked in quality and distribution by any other disease.

show abstract

Pyrexia with dermatitis in dairy cows

Cited by 17 publications

References 0 publications

Experimentos com a polpa cítrica em ovinos e coelhos

Experimentos com a polpa cítrica em ovinos e coelhos

Potential Pathogenetic Role of Bovine Herpesvirus 4 in Two Dairy Cows with Dermatitis-Pyrexia-Hemorrhagic Syndrome

Hairy Vetch (Vicia VillosaRoth) Poisoning in Cattle: Update and Experimental Induction of Disease

Contact Info

Product

Resources

About