Pyrazolopyranopyrimidines as a Class of Anti-Inflammatory Agents

Abstract

Pyrazolopyranopyrimidines 6aÐc and 8aÐc were prepared from the reaction of compounds 4aÐc or 7aÐc with methylamine or ammonium hydroxide solutions. Treatment of compounds 6aÐc or 8aÐc with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9aÐc or 10aÐc, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent antiinflammatory activity.

One Pot Synthesis and Biological Evaluation of Pyranopyrazole in Aqueous Medium

“…Pyranopyrazoles were first obtained in 1973 by the reaction between 3-methyl-1-phenylpyrazolin-5-one and tetracyano ethylene. 6 Pyranopyrazole scaffold has shown bioactivity such as anticoagulant, spasmolytic, hypnotic, diuretic, 7 insecticidal, 8 anti-inflammatory, 9 anticancer, 10 antibacterial and antifungal 11 , as well as antimicrobial. 12 Owing to the biological importance, scientists have developed several methodologies for the synthesis of pyranopyrazoles by using different catalysts such as piperidene, 13 DBSA, 14 PTSA, 15 [Sipim]HSO4, 16 citric acid, 17 β-cyclodextrin, 18 NH4Cl,…”

An Efficient and Green Protocol for the Synthesis of Dihydropyrano [2,3-C] Pyrazoles in Aqueous Medium Using Thiamine Hydrochloride as a Catalyst

“…The pyranopyrazoles have been reported to exhibit interesting biological properties such as antimicrobial, 5 analgesic, 6 antiinflammatory, 7 insecticidal 8 and molluscicidal 9 and also serve as potential inhibitors of human Chk1 kinase. 10 As consequence, synthesis of these important pharmacophore attracted more attention of pharmaceutical industry and organic chemists.…”

Highly Efficient and Chemoselective Synthetic Route to de Thiazolidinones via a Microwave Assisted, Three Component Reaction

“…Also show diverse pharmacological properties as exemplified by antitumor, 12 antimicrobial, 13 insecticidal, 14 and anti-inflamatory 15 activities.…”