A simple one-pot four-component synthesis of pyrano[2,3-c]pyrazoles has been achieved by the condensation of aldehydes, malononitrile, ethyl acetoacetate and hydrazine hydrate using lemon peel powder as a natural catalyst in ethanol under reflux condition. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature of the protocol.
A simple and green one pot protocol for the synthesis of pyranopyrazoles using ultrasonication waves in aqueous medium has been developed. Advantages of this method are it provides operational simplicity and environment-friendly green approach.
Bioactive 1H-indazoles were synthesized from 2-substituted aromatic aldehydes and hydrazine hydrate using DMSO and lemon peel powder as a green and efficient natural catalyst. In comparison to other reported conventional methods, this method affords good yield under ultrasonic irradiation.
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