Pyrazolopyranopyrimidines 6aÐc and 8aÐc were prepared from the reaction of compounds 4aÐc or 7aÐc with methylamine or ammonium hydroxide solutions. Treatment of compounds 6aÐc or 8aÐc with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9aÐc or 10aÐc, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent antiinflammatory activity.
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