Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

Pyranocoumarins Isolated from Peucedanum praeruptorum Dunn Suppress Lipopolysaccharide-Induced Inflammatory Response in Murine Macrophages Through Inhibition of NF-κB and STAT3 Activation

“…These compounds have been found to have anti-cancer, anti-hyperglycemia, anti-microbial, and anti-oxidant properties [19][20][21]. Recently, some pranocoumarins, such as seselin and decursin, have been reported to have anti-inflammatory activities.…”

A Novel One‐pot Protocol for Silica Sodium Carbonate‐Catalyzed Synthesis of Pyrano[2,3‐h]coumarins

“…Pyrano [2,3-h]coumarins as fused dihydropyrans with coumarin nucleus have been shown various pharmacological activities such as anti-HIV, antitumor, anticancer, antibacterial, and anti-inflammatory properties [9][10][11][12]. They are also valuable synthons for the synthesis of many pharmacological agents [13].…”

Crystal and Molecular Structure of 12-(2-Methoxyphenyl)-9-[(4-methylbenzene)sulfonyl]-22-oxo-13,21-dioxa-9-azapentacyclo [12.8.0.02,11.03,8.015,20]docosa-1(14),3,5,7,15(20),16,18-heptaene-11-carbonitrile

“…Antiulcer activity of some naturally occurring pyranocoumarins has been reported [4] . It also shows specific inhibitory activity against Hepatitis B virus, anti-filarial [5] , cytotoxic activites [6] and Mycobacterium tuberculosis [7] . One of the natural source coumarin derivatives named, Chalepin, inhibits the enzyme glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma cruzi and its complex structure has deposited in Protein Data Bank (1K3T) [8] and also sulfonamide based derivatives has wide range biological activity and many of the sulfo based drugs are currently available in the market.…”