Pyoderma Gangrenosum

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β₂A-paraprotein)

“…This fact is reported in at least 9 cases out of 53 patients of the first group. These cases are not different from the rest in any other respect, three of them have arthritis and the morphology of the ulcers conforms to the picture in the other patients [51,13,64,48,73,32,9,55], (b) In the second group of 10, 4 patients with this sym ptom are described [29,26,55).…”

“…The last group, of 54 patients, had no intestinal disorders [22,66,37,18,51,19,23,46,21,72,44,35,33,25,47,74,67,43,65,55,1,53,58,28,5,36,50,57,69,63,41,31,62,29], I. (a) The association o f pyoderma gangraenosum and arthritis in the patients with colitis ulcerosa.…”

“…In one case [30] sterile pus was found on puncturing. In four cases the involvem ent of the joints is styled as " arthritis" [11,30,32,55], in one case as acute rheum atism [38] and in another case as early osteoarthrosis [40]. To this total of 12 patients out of 53, a num ber of the cases of Perry and Brunsting [55] should perhaps be added, as these authors fail to indicate in 6 of their cases suffering from arthritis whether or not they had colitis ulcerosa.…”

“…In this group of 54 cases 6 patients are mentioned as having swell ings of the big joints [43,55,1,53,50, 69] and 9 as suffering from " arthritis" [66,25,55,1,58,41,62]. Finally one patient is described as having an arthrosis of the spine.…”

“…(a) The simultaneous im provem ent and relapse of sym ptom s of colitis ulcerosa and pyoderma gangraenosum and sometimes of ar thritis as well is mentioned for at least 34 of the 53 patients of the first group [51,11,13,48,73,30,17,12,32,20,70,61,55,54,15,45,27,41,39,71].…”