Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β&lt;sub&gt;2&lt;/sub&gt;A-paraprotein)

Sluis, I.v.d.

doi:10.1159/000254441

Cited by 72 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Provocation of new lesions by trauma is called pathergy and is seen in about 20% of pyoderma gangrenosum cases (12). In our patient, however, traumatic injuries did not always induce the skin lesions.…”

Section: Discussioncontrasting

confidence: 45%

Acute Form of Pyoderma Gangrenosum Induced by Traumatic Injury

Kitagawa,

Ikeda,

Kodama

1996

The Journal of Dermatology

View full text Add to dashboard Cite

A 45‐year‐old man with the acute form of pyoderma gangrenosum is reported. He developed characteristic ulcers that rapidly followed violaceous erythema at sites of traumatic injury. The skin lesions repeatedly appeared six times within 7 years. Each time, the skin lesions were localized to sites of trauma, and no systemic symptoms nor abnormal laboratory findings were associated. Histological findings were acute superficial inflammation with neutrophilic infiltration into the dermis. Sweet's syndrome‐like skin lesions were once associated, indicating that pyoderma gangrenosum and Sweet's syndrome have a close relationship. Nonsteroidal antiinflammatory drugs, potassium iodide, and minocycline were not effective. He was successfully treated with oral administration of corticosteroid. The pathergy of this patient must have been caused not only by the trauma itself but by additional factors such as epidermal components or contaminating micro‐organisms, since traumatic injury did not always cause the skin lesions.

show abstract

Section: Discussioncontrasting

confidence: 45%

Acute Form of Pyoderma Gangrenosum Induced by Traumatic Injury

Kitagawa,

Ikeda,

Kodama

1996

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…In their original description, Brunsting and co‐workers believed that the disorder had a bacterial origin, hence the name pyoderma. 1 However, van der Sluis 23 and Holt and colleagues 9 showed that bacterial colonization of ulcers is a secondary phenomenon and that early pustular lesions are sterile. Rostenberg suggested a Schwartzman‐like phenomenon whereby altered tissue reactivity, sensitized to an exogenous antigen, is manifested as a hypersensitivity reaction in the skin 24 .…”

Section: Commentsmentioning

confidence: 99%

“…Neutrophil dysfunction has also been demonstrated, including inappropriate responses to a variety of antigens, impaired random mobility, and deficient phagocytosis 25,26 . Recent investigations have emphasized alterations of the immune system: hypergammaglobulinemia, hypogamma‐globulinemia, myeloma proteins, and paraprotein‐emia have been documented 23,27–31 . Abnormalities reported in cellular immunity are defective mono‐cyte phagocytosis, cutaneous anergy to dinitro‐chlorobenzene and to recall antigens, and dissociation between blastogenic response and macrophage inhibitory factor production 32,33 .…”

Section: Commentsmentioning

confidence: 99%

See 1 more Smart Citation

Residents' Corner: Pyoderma Gangrenosum at Surgery Sites

Fulbright

Wolf

Tschen

1985

The Journal of Dermatologic Surgery and Oncology

View full text Add to dashboard Cite

Pyoderma gangrenosum is a necrotizing and ulcerative skin disorder often associated with underlying systemic diseases. The etiology remains obscure, with recent investigations emphasizing an altered immune system. A case report is presented of pyoderma gangrenosum occurring at surgical sites in the absence of predisposing factors. Pyoderma gangrenosum in this setting can mimic infectious causes of wound necrosis. Early recognition of the characteristic lesion morphology may prevent unnecessary treatment directed toward infectious agents and facilitate effective control with systemic corticosteroid therapy.

show abstract

“…Articular manifestations are frequently reported in patients with pyoderma gangrenosum [12]. In addition to rheumatoid arthritis [13], a review of the literature [10] showed the following four main types of arthropathy: (1) chronic, progressive, seronegative polyarthritis [13][14][15], (2) seronegative polyarthritis that paralleled the course of skin manifestation [16], (3) seronegative spondyloarthropathy [17], and (4) 'colitis arthritis' [18].…”

mentioning

confidence: 99%