Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy

Harrist, Terence J.

doi:10.1001/archderm.118.4.263

Cited by 126 publications

(82 citation statements)

References 14 publications

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“…Myelodysplastic syndrome (MDS) and other hematological disorders, such as leukemia or more rarely myeloma, have recently been recognized to be associated with skin diseases characterized by a neutrophilic infiltration in the dermis, which clinically resembles acute febrile neutrophilic dermatosis (Sweet’s syndrome) or pyoderma gangrenosum [1, 2, 3, 4, 5, 6], erythema elevatum et diutinum [7, 8]and neutrophilic eccrine hidradenitis [9, 10]. Although the detailed mechanisms of these diseases are unknown, a role of hematopoietic cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), has been suggested.…”

Section: Introductionmentioning

confidence: 99%

Abscess-Forming Neutrophilic Dermatosis: Report of Three Cases Associated with Hemopathies

Horiguchi¹,

Lee²,

Matsumoto³

et al. 1998

Dermatology

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Background: The development of different types of neutrophilic dermatosis is reported to occur in the course of malignant hemopathies. These concern mainly Sweet’s syndrome, pyoderma gangrenosum, erythema elevatum et diutinum and neutrophilic eccrine hidradenitis. Observations: We have recently encountered the cases of 3 patients who presented all with multiple acneiform papules and dome-shaped aseptic abscesses leaving scars. Pus was sterile in all except case 3 in which slight Staphylococcus aureus growth was shown. However, in this patient, only steroids were effective demonstrating that this bacterium was not responsible for the disease. Histopathology disclosed a dense dermal polymorphonuclear neutrophil infiltrate and some mononuclear cells. Two of these patients had myelodysplastic syndromes while one had IgA myeloma. Conclusion: Abscess-forming neutrophilic dermatosis seems to be another type of neutrophilic dermatosis associated with hematological malignancies.

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Section: Introductionmentioning

confidence: 99%

Abscess-Forming Neutrophilic Dermatosis: Report of Three Cases Associated with Hemopathies

Horiguchi¹,

Lee²,

Matsumoto³

et al. 1998

Dermatology

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“…3,4 In contrast to neutrophilic eccrine hidradenitis (NEH), which was described by Harrist et al 5 in 1982, IRPH is characterized by multiple tender erythematous nodules on the soles and, in some cases, also the palms of otherwise healthy young persons. Histologically, neutrophilic infiltrates localized to the eccrine coils in the deep reticular dermis are characteristic.…”

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confidence: 99%

Idiopathic Recurrent Palmoplantar Hidradenitis in Children

Simon¹,

Cremer²,

Driesch³

1998

Arch Dermatol

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Background: Idiopathic recurrent palmoplantar hidradenitis (IRPH) is characterized by tender erythematous plaques and nodules on the soles and, less often, the palms of young patients. To date, 10 cases of IRPH have been documented in the literature.Observations: We describe 22 pediatric patients with characteristic cutaneous and histologic findings of IRPH. Their mean age was 6 years (age range, 1.5-15 years). The onset of the disease clustered in 2 peaks, in autumn and spring. All patients had complete resolution of their lesions within 3 weeks, in 16 cases without any treat-

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“…The problem of squamous syringometaplasia is less significant as the degree of atypia is typically less in this scenario; there should be evidence either of a surgical insult or of individual cell necrosis of the eccrine apparatus due to chemotherapy and/or neutrophilic hidradenitis. 251 Furthermore, a clinical history of previous cancer with appropriate chemotherapy should be available if the appropriate questions are asked. At times mucoepidermoid carcinoma may be confused with adenosquamous carcinoma.…”

Section: Differential Diagnosismentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy

Cited by 126 publications

References 14 publications

Abscess-Forming Neutrophilic Dermatosis: Report of Three Cases Associated with Hemopathies

Abscess-Forming Neutrophilic Dermatosis: Report of Three Cases Associated with Hemopathies

Idiopathic Recurrent Palmoplantar Hidradenitis in Children

Malignant adnexal neoplasms

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