Pyoderma gangrenosum

Abstract

Since its description 50 years ago, pyoderma gangrenosum has continued to capture the attention and imagination of all those who see its dramatic presentation. Clinical observation still provides the only reliable diagnosis. As investigative techniques increase, more and more intriguing immunologic abnormalities associated with this disorder are discovered, but understanding of the pathogenesis remains elusive. It is now recognized as an independent condition as well as a co-condition with many systemic disorders. Many new treatment options are available, allowing much individualization of treatment. For now, pyoderma gangrenosum remains an impressive, relatively easily recognized, but poorly understood disease.

Dermatoses neutrofílicas: parte I

“…Other changes are found in the eyes ( necrotic sclerokeratitis), liver (hepatitis, granulomas), spleen, bones, bone marrow (alterations in red blood cells, white cells and platelets). 26,27,32,[40][41][42][43][44] Death can occur, albeit rarely. In general, it occurs in patients with severe associated diseases.…”

“…39 In 30% of the patients, there are multiple lesions and pain is the main symptom, though some do not report specific symptoms. 40 The location of the lesions is variable, with a preferential topography: the lower extremities, abdomen, upper extremities, breasts, buttocks, genitals and face. In children, lesions are mostly found in the head, neck and perineum.…”

“…In children, lesions are mostly found in the head, neck and perineum. 26,27,[30][31][32]40 The most common extracutaneous clinical manifestations occur in the lungs, joints and digestive tract and are due to the general inflammatory process. Pulmonary involvement may lead to the development of pleural effusion, nodules, cavitation, bronchial pneumonia and abscess.…”

Investigations on the role of flea antigen in the pathogenesis of German Shepherd dog Pyoderma (GSP)

“…Although specific precipitating factors for GSP have not been found so far, the observation of the early and prolonged local neutrophilic reactions to injections with flea antigen in GSP dogs is interesting. For instance, in humans with pyoderma gangrenosum, intense polymorphic infiltration itself is supposed to contribute to the development of skin lesions by the action of its secretory products (7,11). The same mechanism might play a role in the development of GSP lesions.…”

“…Pyoderma gangrenosum (7,12,15) is an uncommon idiopathic skin disease characterised by distinct chronic ulcerations. The macroscopic appearance of skin lesions in pyoderma gangrenosum and GSP is similar.…”