Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

Lauritzen, Brian; Lykkesfeldt, Jens; Skaanild, M.T; Angen, Øystein; Nielsen, Jens Peter; Friis, Christian

doi:10.1016/s0034-5288(03)00028-6

Cited by 59 publications

(53 citation statements)

References 33 publications

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“…Plasma concentrations of CRP correlate well to the clinical score and the effect of antibiotic treatment in experimental A. pleuropneumoniae infection in pigs [98,99].…”

Section: Porcine C-reactive Proteinmentioning

confidence: 79%

“…The serum and plasma concentration of CRP increases after turpentine induced aseptic inflammation in pigs [38,96] and infections with A. pleuropneumoniae [64,98,99]. Plasma concentrations of CRP correlate well to the clinical score and the effect of antibiotic treatment in experimental A. pleuropneumoniae infection in pigs [98,99].…”

Section: Porcine C-reactive Proteinmentioning

confidence: 91%

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Application of acute phase protein measurements in veterinary clinical chemistry

2004

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-The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these acute phase proteins returns to base levels when the triggering factor is no longer present. This paper provides a review of the acute phase proteins haptoglobin, C-reactive protein and serum amyloid A and their possible use as non-specific indicators of health in large animal veterinary medicine such as in the health status surveillance of pigs at the herd level, for the detection of mastitis in dairy cattle and for the prognosis of respiratory diseases in horses.

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“…Plasma concentrations of CRP correlate well to the clinical score and the effect of antibiotic treatment in experimental A. pleuropneumoniae infection in pigs [98,99].…”

Section: Porcine C-reactive Proteinmentioning

confidence: 79%

Section: Porcine C-reactive Proteinmentioning

confidence: 91%

Application of acute phase protein measurements in veterinary clinical chemistry

2004

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“…The main reason for this was to discard the potential effects of viral and bacterial pathogens which have been demonstrated to cause an increase in serum APP, such as PRRSV, Pasteurella multocida, Bordetella bronchiseptica, Streptococcus suis and Actinobacillus pleuropneumoniae [2,13,17,20,22,27]. Therefore, the values obtained reflected the effect of PCV2-associated disease and discard the effect of other potential known diseases.…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS)

Segalés

Piñeiro²,

Lampreave

et al. 2004

Vet. Res.

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-The objective of this study was to determine the serum concentration levels of selected acute phase proteins (APP), haptoglobin (HPT) and pig-major acute phase protein (pig-MAP), in postweaning multisystemic wasting syndrome (PMWS) affected pigs and PCV2-subclinically infected pigs. In a first study, a group of 15 eight-week-old conventional pigs from a PMWS affected farm were bled and a complete necropsy, histopathology and in situ hybridisation to detect PCV2 were performed. Based on the results, pigs were classified as suffering from PMWS (n = 10) or healthy animals (n = 5). In a second study, a group of 45 pigs from another PMWS affected farm were selected and bled at 3, 7, 12 and 28 weeks of age. The assessment of PCV2 infection status in these pigs was retrospectively done by PCV2 PCR in serum samples. Selected APP were measured in the serum of all studied pigs by means of radial immunodiffusion. Mean HPT and pig-MAP levels were significantly increased (p = 0.004 and p = 0.0006 respectively) in PMWS-affected pigs when compared to levels found in healthy pigs (2.52 ± 0.88 mg/mL vs. 1.06 ± 0.73 mg/mL for HPT and 3.81 ± 1.53 mg/mL vs. 0.76 ± 0.34 mg/mL for pig-MAP). In the second study, no significant difference in mean HPT and pig-MAP values were observed between PCV2 PCR positive and negative pigs of any age. However, both APP increased significantly with age in PCV2 PCR negative pigs. Altogether, the present results suggest that APP levels are significantly increased in pigs that develop PMWS, but not in animals with a PCV2 subclinical infection. porcine circovirus type 2 (PCV2) / postweaning multisystemic wasting syndrome (PMWS) / acute phase proteins / haptoglobin / pig major acute phase protein (pig-MAP)

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“…Although the exact mechanism by which ZAG actively participates in tumor proliferation is not known, a large body of data exists in favor of the expression of ZAG with respect to the stages of tumor (39)(40)(41)(42). ZAG is designated as a potential biomarker of different types of carcinomas (6,7,27,35,38,(43)(44)(45)(46).…”

Section: Zag As a Biomarkermentioning

confidence: 99%

Zinc α2-Glycoprotein: A Multidisciplinary Protein

Hassan

Waheed

Yadav

et al. 2008

Molecular Cancer Research

205

187

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Zinc A2-glycoprotein (ZAG) is a protein of interest because of its ability to play many important functions in the human body, including fertilization and lipid mobilization. After the discovery of this molecule, during the last 5 decades, various studies have been documented on its structure and functions, but still, it is considered as a protein with an unknown function. Its expression is regulated by glucocorticoids. Due to its high sequence homology with lipid-mobilizing factor and high expression in cancer cachexia, it is considered as a novel adipokine. On the other hand, structural organization and fold is similar to MHC class I antigen-presenting molecule; hence, ZAG may have a role in the expression of the immune response. The function of ZAG under physiologic and cancerous conditions remains mysterious but is considered as a tumor biomarker for various carcinomas. There are several unrelated functions that are attributed to ZAG, such as RNase activity, regulation of melanin production, hindering tumor proliferation, and transport of nephritic by-products. This article deals with the discussion of the major aspects of ZAG from its gene structure to function and metabolism. (Mol Cancer Res 2008;6(6):892 -906)

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Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

Cited by 59 publications

References 33 publications

Application of acute phase protein measurements in veterinary clinical chemistry

Application of acute phase protein measurements in veterinary clinical chemistry

Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS)

Zinc α2-Glycoprotein: A Multidisciplinary Protein

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