Purification, characterization and utilization of polysaccharide of Araucaria heterophylla gum for the synthesis of curcumin loaded nanocarrier

Samrot, Antony V.; Angalene, J. Lavanya Agnes; Roshini, S. M.; Stefi, S.M.; Preethi, R.; Raji, P.; Kumar, Awadhesh; Paulraj, Ponnaiah; Kumar, S. Suresh

doi:10.1016/j.ijbiomac.2019.08.121

Cited by 41 publications

(22 citation statements)

References 31 publications

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“…Nanotechnology is a blooming field of science and has variety of applications in the field of science (Kreuter et al 2003). Applications of nanoparticles in various fields include agriculture, drug delivery (Samrot et al 2019a), imaging , Justin et al 2018, Sruthi et al 2018, Samrot et al 2018a, mosquito larvicidal activity (Samrot et al 2019b), environmental remediation (Samrot et al 2019c), bioactivity including anticancer and antibacterial activity (Samrot et al 2016, Samrot et al 2018b, Samrot et al 2019a. The increased usage creates demand in the production alleviating the risks associated with improper disposal of metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

A study on influence of superparamagnetic iron oxide nanoparticles (SPIONs) on green gram (Vigna radiata L.) and earthworm (Eudrilus eugeniae L.)

Samrot

et al. 2020

Mater. Res. Express

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Nanoparticles usage are now emerging as hazardous nanopollutants due to inappropriate usage and improper disposal. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) is a widely used nanoparticle with various applications. In this study, SPIONs was evaluated for its impact against Vigna radiata and Eudrilus eugeniae. SPIONs were synthesized by chemical co-precipitation method in presence of cobalt chloride. The produced SPIONs was characterized using UV-Visible Spectroscopy, SEM (Scanning electron microscopy), EDX (Energy dispersive X-ray spectroscopy), XRD (X-ray diffraction), TEM (Transmission electron microscopy), AFM (Atomic force microscopy), XPS (X-ray photoelectron spectroscopy) and Zeta potential. The synthesized SPIONs were crystalline and monodispersed with size ranging between 15 nm and 20 nm. The seedlings of SPIONs treated Vigna radiata were found to have reduced root and shoot growth. The bioaccumulation of iron oxide in the treated plants was confirmed by ICP-OES (Inductively coupled plasma -optical emission spectrometry) analysis and Prussian blue staining. Cellular destruction and reduced reproduction rate were found in SPIONs exposed Eudrilus eugeniae and ICP-OES analysis of earthworm samples affirmed the bioaccumulation of SPIONs.

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Section: Introductionmentioning

confidence: 99%

A study on influence of superparamagnetic iron oxide nanoparticles (SPIONs) on green gram (Vigna radiata L.) and earthworm (Eudrilus eugeniae L.)

Samrot

et al. 2020

Mater. Res. Express

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“…1,2 Their surface area interaction of these nanoparticles leads to unique properties 3,4 and it can be applied in electronics, biomedicine, imaging, environmental remediation etc. [5][6][7][8][9][10] In nanobiotechnology, the recent decade has recorded extensive research on formulation of nanocarriers since they promote easy transport and availability of drug molecules to the targeted site. Nanocarriers are being formulated from both inorganic and organic resources.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Purification, and Characterization of Polysaccharides of Araucaria heterophylla L and Prosopis chilensis L and Utilization of Polysaccharides in Nanocarrier Synthesis

Samrot¹,

Kudaiyappan²,

Bisyarah³

et al. 2020

IJN

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Background: Plant gums consist of polysaccharides which can be used in the preparation of nanocarriers and provide a wide application in pharmaceutical applications including as drug delivery agents and the matrices for drug release. The objectives of the study were to collect plant gums from Araucaria heterophylla L and Prosopis chilensis L and to extract and characterize their polysaccharides. Then to utilize these plant gum-derived polysaccharides for the formulation of nanocarriers to use for drug loading and to examine their purpose in drug delivery in vitro. Methods: Plant gum was collected, polysaccharide was extracted, purified, characterized using UV-Vis, FTIR, TGA and GCMS and subjected to various bioactive studies. The purified polysaccharide was used for making curcumin-loaded nanocarriers using STMP (sodium trimetaphosphate). Bioactivities were performed on the crude, purified and drugloaded nanocarriers. These polysaccharide-based nanocarriers were characterized using UV-Vis spectrophotometer, FTIR, SEM, and AFM. Drug release kinetics were performed for the drug-loaded nanocarriers. Results: The presence of glucose, xylose and sucrose was studied from the UV-Vis and GCMS analysis. Purified polysaccharides of both the plants showed antioxidant activity and also antibacterial activity against Bacillus sp. Purified polysaccharides were used for nanocarrier synthesis, where the size and shape of the nanocarriers were studied using SEM analysis and AFM analysis. The size of the drug-loaded nanocarriers was found to be around 200 nm. The curcumin-loaded nanocarriers were releasing curcumin slow and steady. Conclusion: The extracted pure polysaccharide of A. heterophylla and P. chilensis acted as good antioxidants and showed antibacterial activity against Bacillus sp. These polysaccharides were fabricated into curcumin-loaded nanocarriers whose size was below 200 nm. Both the drug-loaded nanocarriers synthesized using A. heterophylla and P. chilensis showed antibacterial activity with a steady drug release profile. Hence, these natural exudates can serve as biodegradable nanocarriers in drug delivery.

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“…Diffraction points of 38°, 44.5°, 64.81°, 77.43° corresponding to (111), (200), (220), (311) planes confirmed the presence of crystalline structures in XRD (Fig. 5) analysis 21 .…”

Section: Results and Discussion Characterization Of Silver Nanoparticlesmentioning

confidence: 64%

Green Synthesis and Antibacterial Activity Studies of Silver Nanoparticles from the Aqueous Extracts of Euphorbia hirta

D¹,

Raji²,

M³

et al. 2020

J. Pure Appl. Microbiol.

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The aqueous extracts of Euphorbia hirta was used to synthesise silver nanoparticles using bioreduction method. The nanoparticles were characterised by UV Vis spectroscopic analysis, SEM, EDX, AFM, XRD analysis. The silver nanoparticles were also tested for antibacterial activity in Pseudomonas aeruginosa and Bacillus subtilis. The minimum inhibitory concentration for the synthesised nano particles were also tested against the two bacterial species for the least concentration of 0.5µg/mL. The swarming motility assay and protein leakage assay was also tested for the nanoparticle. The silver nanoparticles were found to be much effective.

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Purification, characterization and utilization of polysaccharide of Araucaria heterophylla gum for the synthesis of curcumin loaded nanocarrier

Cited by 41 publications

References 31 publications

A study on influence of superparamagnetic iron oxide nanoparticles (SPIONs) on green gram (Vigna radiata L.) and earthworm (Eudrilus eugeniae L.)

A study on influence of superparamagnetic iron oxide nanoparticles (SPIONs) on green gram (Vigna radiata L.) and earthworm (Eudrilus eugeniae L.)

<p>Extraction, Purification, and Characterization of Polysaccharides of <em>Araucaria heterophylla</em> L and <em>Prosopis chilensis</em> L and Utilization of Polysaccharides in Nanocarrier Synthesis</p>

Green Synthesis and Antibacterial Activity Studies of Silver Nanoparticles from the Aqueous Extracts of Euphorbia hirta

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