Pure Water-Induced Dehalogenation of 2,4-Di-tert-amino-6-substituted-5-halogenopyrimidines

Abstract

Dehalogenation of 5-halogenopyrimidine derivatives in boiling pure water was accomplished in high yields. The substrate and pure water are the only two reaction components in this process. Dehalogenation takes place in the absence of any catalysts, additives, basic, or acidic conditions, introducing water as a potential dehalogenation reagent.

Metal‐Free Debromination of 5‐Bromopyrimidine Derivatives Using DMF/Trialkylamine as the Hydrogen Source

“…As shown in Scheme , compounds 1(a–e) which were synthesized from 5‐bromo‐2,4‐dichloro‐6‐(chloromethyl)pyrimidine according to the published procedure were used as precursors for further preparation of pyrimidothiadiazepine during a cyclization process.…”

On‐Water and Efficient Ullmann‐Type O‐Arylation Cross Coupling Reaction of Phenols and Aryl Tosylates in the Presence of Fe3O4@Starch‐Au as Nanocatalyst

“…As a whole, in continuation of our previous studies, [5,54–59] inspired by the above facts and considering to introduce an efficient and environmentally benign heterogeneous nanocatalyst, it is highly desirable to develop the use of nanoparticle of gold supported on a thin layer of magnetite@starch as a catalyst system for the study of Ullman‐type diaryl ethers synthesis.…”

Waste-Minimized Protocol for the Synthesis of Sulfonylated N-Heteroaromatics in Water

“…The development of step- and atom-economical aqueous organic reactions − that can be conducted under neutral, metal-free, and mild reaction conditions in which the desired products can be obtained after the reaction through simple filtration without organic solvent extraction and recrystallization is one of the important targets in green chemistry. Over the past decades, the achievement of general and efficient protocols for the synthesis of sulfonylated N -heteroaromatics has attracted extensive attention of organic chemists because they have a wide range of applications in organic synthesis, pharmaceuticals, and functionalized material science. − Thus, tremendous efforts have been dedicated to construct such motifs.…”