The first example of direct synthesis of 2-sulfonylquinolines through visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with organic dye as the catalyst and ambient air as the sole oxidant was developed.
α-Oxo gold carbenes generated via intermolecular oxidation of terminal alkynes are shown to be highly electrophilic and can effectively abstract halogen from halogenated solvents such as 1,2-dichloroethane or 1,2-dibromoethane. Chloro/bromomethyl ketones are prepared in moderate efficiencies in one step using Ph(3)PAuNTf(2) as the catalyst and 8-methylquinoline N-oxide as the oxidant.
A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through hydration of a wide range of haloalkynes. Other outstanding features include excellent yields from both alkyl- and aryl-substituted haloalkynes and wide functional group tolerance. This protocol is an alternative to conventional α-halogenation of ketones.
A efficient and sustainable approach
for the synthesis of 3-alkylquinoxalin-2(1H)-ones
has been developed through visible-light-mediated
decarboxylative alkylation of quinoxalin-2(1H)-ones
with phenyliodine(III) dicarboxylates. This photocatalytic alkylation
reaction could be conducted at ambient temperature by employing eco-friendly
PEG-200 as the reaction medium. Various 3-alkylquinoxalin-2(1H)-ones were easily obtained through the present ruthenium(II)
catalytic system, which could be successfully recycled five times
without the significant decrease of its efficiency.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.