A practical protocol for the preparation of quinoxaline-2,3(1H,4H)-diones through direct C (sp 2 )À H hydroxylation of quinoxalin-2(1H)-ones in recyclable DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) (TPGS-750-M/H 2 O) was developed. The target products were exclusively generated and could be collected through extraction and recrystallization.

An economic, safe, practical, and environmentally benign protocol for the oxidation of aldehydes to carboxylic acids and acid anhydrides with ambient air as the sole oxidant was developed. This oxidation is operationally simple and external catalyst-, initiator-, and base-free, with outstanding functional group tolerance (moisture-, acid-, base-, and oxidant-sensitive groups). It also provides a practical protocol for large scale synthesis (>100 g), late-stage modification of polyfunctional compounds, and one-pot sequential transformation starting from aldehydes.

A facile, practical and environmentally attractive protocol for the direct diversification of N-heterocycles under ambient, metal- and base-free conditions was developed.

No abstract

Without using any base and organic solvent, an environmentally benign methodology was developed for the aqueous synthesis of various functionalized quinolin-2(1H)ones at ambient temperature. The developed protocol has a wide substrate scope, excellent to quantitative yields, short reaction time (1−8 min), operational simplicity, reusable reaction medium and avoids further chromatographic purification. More importantly, this methodology is markedly greener than the traditional routes with an E-factor of 1.6 and eco-scale score of 89.5.

An economic and eco-friendly straightforward synthesis of highly diversified N-acylated 2-aminoquinolines is successfully achieved via Brønsted acidic ionic liquid-promoted amidation of quinoline N-oxides with nitriles. The advantage of this present process is highlighted by its easily accessible starting materials, excellent functional group tolerance, 100% atom economy, operational simplicity, and clean reaction profile.

The first example of a metal- and reductant-free deoxygenative sulfonylation of quinoline N-oxides with sodium sulfinates via a dual radical coupling process is reported.

No abstract