Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in Mice

Habibi, Emran; Shokrzadeh, Mohammad; Ahmadi, Amirhossein; Chabra, Aroona; Naghshvar, Farshad; Haghi‐Aminjan, Hamed; Salehi, Fatemeh

doi:10.1007/s11655-018-2984-4

Cited by 21 publications

(12 citation statements)

References 39 publications

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“…The results showed that the plant protects lung tissues against CP‐induced toxicity. Thus, Z. multiflora may be used concomitantly as a good supplement for reducing organ toxicity in patients undergoing chemotherapy (Habibi et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that the plant protects lung tissues against CP-induced toxicity. Thus, Z. multiflora may be used concomitantly as a good supplement for reducing organ toxicity in patients undergoing chemotherapy(Habibi et al, 2020).The effect of the Z. multiflora extract at three different concentrations of 5, 10, and 50 μg/ml for 1 hr on human lymphocytes micronuclei in cytokinesis-blocked binucleated cells was examined. The whole blood was exposed in vitro to 150 cGy of cobalt-60 γ irradiation, and then the lymphocytes were cultured with mitogenic stimulation to determine the number of the micronuclei in cytokinesis-blocked binucleated cells.…”

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confidence: 99%

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The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review

Ghorani

Beigoli

Khazdair

et al. 2022

Phytotherapy Research

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Zataria multiflora (Z. multiflora) is used in traditional and modern medicine for therapeutic objectives especially in respiratory disorders. Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various electronic search engines including PubMed, Science Direct, Scopus, and Google Scholar were searched using appropriate keywords until the end of November 2021. Books, thesis-hard copies of some articles were also included. The effects of Z. multiflora on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection, and lung cancer were shown. Extracts of Z. multiflora showed the relaxant effect with various mechanisms. The preventive effects of Z. multiflora were also demonstrated by mechanisms such as antioxidant, immunomodulatory, and antiinflammatory properties in the experimental animal models of different respiratory diseases. Carvacrol and thymol are probably responsible for the therapeutic effect of plant among 56 constituents of Z. multiflora. In addition, bronchodilatory and preventive effects of the plant and its constituents on asthma, COPD, lung disorders due to noxious agents and allergic and immunologic disorders were shown in the clinical studies. Therefore Z. multiflora and its constituents may be considered as a preventive and/or relieving therapy in various respiratory diseases.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review

Ghorani

Beigoli

Khazdair

et al. 2022

Phytotherapy Research

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“…Kanser kemoterapisinde kullanılan, alkilleyici bir ajan olan CYP'nin birçok yan etkisi olduğu bilinmektedir. Toksik etkiye sahip olması ise, metabolitlerinden biri olan akrolein üretimi ile alakalıdır 30,31 . Akrolein α, β-doymamış bir aldehittir ve oldukça reaktif olan bu bileşik lipid peroksidasyonunun bir göstergesi olarak tanımlanır 32 .…”

Section: Discussionunclassified

Ratlarda Siklofosfamid ile İndüklenen Hepatotoksisite Üzerine Kuersetinin Etkileri

Gedikli¹,

Şengül²

2019

Dicle Tıp Dergisi

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ÖzAmaç: Siklofosfamid (CYP), karaciğer ve akciğer gibi birçok organda toksisiteye neden olur. Pek çok çalışmada bazı antioksidanların CYP'nin yan etkilerine karşı koruyucu etkileri olduğu gösterilmiştir. Bu çalışmada, kuersetinin histolojik ve biyokimyasal yöntemler kullanılarak sıçanlarda CYP ile indüklenen hepatotoksisite üzerindeki koruyucu etkisinin araştırılması amaçlanmıştır.Yöntemler: Otuz Sprague-Dawley erkek sıçan 5 gruba ayrıldı. Kontrol grubuna 7 gün boyunca intragastrik olarak mısıryağı verildi. CYP grubuna 7 gün intragastrik olarak mısır yağı verildi ve 7. günde intraperitoneal olarak CYP (200 mg/kg) uygulandı. 7 gün boyunca Q50+CYP ve Q100+CYP gruplarına sırasıyla kuersetin verildi ve 7. günde tek doz CYP (200 mg/kg) uygulandı. Q100 grubuna günde 100 mg/kg dozda kuersetin verildi. 8. günde biyokimyasal ve histopatolojik incelemeler için kan örnekleri ve karaciğer dokuları alındı.Sonuç: Elde ettiğimiz sonuçlar, kuersetinin siklofosfamidle indüklenen hepatotoksisite üzerinde koruyucu etkiye sahip olduğunu göstermektedir.Bulgular: MDA seviyesinin kontrol grubu ile karşılaştırıldığında CYP grubunda belirgin olarak yüksek olduğunu ve kuersetin uygulaması ile azaldığını tespit ettik. SOD ve GSH düzeyleri CYP grubunda kontrol, Q50+CYP, Q100+CYP ve Q100 gruplarına göre azalmıştı. Histolojik analizlerde CYP grubunda sinüsoidal dilatasyon, mononükleer hücre infiltrasyonu ve vasküler konjesyon gözlenirken, bu dejeneratif değişikliklerin kuersetin uygulaması ile azaldığı tespit edildi. TUNEL yönteminde, CYP grubunda kontrol grubuna kıyasla fazla sayıda TUNEL pozitif hepatosit tespit edildi. Ayrıca Bax ve Caspase-3 immunpozitivitesi açısından CYP grubunda diğer gruplara oranla imünpozitiflik fazla iken, Bcl-2 immunpozitivitesi CYP grubunda diğer gruplardan daha düşüktü.Gedikli S., Şengül E. AbstractObjective: Cyclophosphamide (CYP) causes toxicity in many organs, as liver and lung. Several studies have shown that some antioxidants have protective effects against CYP' side effects. This study aimed to investigate the protective effect of quercetin-Q on CYP-induced hepatotoxicity in rats using histological and biochemical methods.Methods: Thirty Sprague-Dawley male rats were divided into 5 groups. Control group was given corn oil intragastrically for 7 days. CYP group was given intragastric corn oil for 7 days and CYP (200 mg/kg) was administered intraperitoneally on the 7th day. For 7 days, Q50+CYP and Q100+CYP groups were given quercetin and single dose CYP (200 mg/kg) was administered on the 7th day. Q100 group was given quercetin 100 mg/kg dose per day. On the 8th day, blood samples and liver tissues were taken for biochemical and histopathological examinations.Results: When MDA level was compared with the control group, it was higher in the CYP group and decreased with the administration of quercetin. SOD and GSH levels were lower in the CYP group compared to the other groups. Histological analysis revealed that sinusoidal dilatation and mononuclear cell infiltration were observed in the CYP group, and these ...

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“…Endogenous sources of ROS are cellular organelles where oxygen consumption is high, such as mitochondria, peroxisomes, and endoplasmic reticulum [2]. Exogenous sources of ROS are hazardous environmental chemicals which, as shown for the alkylating antineoplastic agent cyclophosphamide, produce free radicals during their metabolic conversion (see, for instance [3]). Furthermore, in individuals with inherited erythrocyte glucose-6-phosphate dehydrogenase deficiency [4], the red blood cells provide insufficient NADPH in response to the rate of ROS formation, resulting in the accumulation of ROS, damage to the red blood cells, and hemolytic anemia (see, for instance, [5]).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Surinamese Medicinal Plants with Adaptogenic Properties and Correlation with Total Phenolic Contents

Mans

Friperson

Pawirodihardjo

et al. 2020

JAA

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Plant-based preparations are commonly used in Suriname (South America) as adaptogens. In this study, fifteen alleged adaptogenic Surinamese plants have been assessed for their antioxidant activity (AA), total phenolic contents (TPC), and total flavonoid contents (TFC). The investigated plants were Anacardium occidentale, Spondiasdulcis, Annona muricata, Euterpe oleracea, Oenocarpus bacaba, Luffa acutangula, Punicagranatum, Malpighia emarginata, Syzygiumaqueum, Syzygiumcumini, Averrhoa carambola, and Renealmiaalpinia (fruit); Hibiscus sabdariffa (calyx); as well as Aloe vera and Cestrum latifolium (leaf). Aqueous extracts (1 - 3,000 μg/ mL) were prepared. AA was determined by the FRAP and the DPPH assay. TPC and TFC were determined by the Folin-Ciocalteu’s and an AlCl3 colorimetric method, respectively, using gallic acid (GA) and rutin (R), respectively, as standards. Data are means ± SDs (n ≥ 3; P < 0.05). FRAP values and DPPH-scavenging activities correlated positively with each other and with TPC but not with TFC. The preparations from M. emarginata, A. carambola, A. occidentale, O. bacaba, C. latifolium, and H. sabdariffa displayed the highest FRAP values (54 ± 14 to 412 ± 30 µM Fe2+/100 μg), DPPH-scavenging activities (IC50 values of 33 ± 14 to 250 ± 50 μg/mL), and TPC (51 ± 4 to 280 ± 78 µM GAE/100 µg). TFC of all samples were ≤ 10 ± 3 RE/100 µg. The adaptogenic properties of these plants may (partially) be attributed to their high content of antioxidant phenolic compounds and may make them candidates of novel sources of health-promoting antioxidants.

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Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in Mice

Cited by 21 publications

References 39 publications

The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review

The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review

Ratlarda Siklofosfamid ile İndüklenen Hepatotoksisite Üzerine Kuersetinin Etkileri

Antioxidant Activity of Surinamese Medicinal Plants with Adaptogenic Properties and Correlation with Total Phenolic Contents

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