Pulmonary Vein Thrombosis Associated with Metastatic Follicular Thyroid Carcinoma: A Case Report and Review

Mavromati, Maria; Gerber, Annick; John, Gregor

doi:10.1155/2018/6096704

Cited by 4 publications

(11 citation statements)

References 18 publications

(51 reference statements)

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“…In our patient, the diagnosis was made by pulmonary CT angiography. The thrombus was located at the branches of both the right [ 5 – 7 , 9 , 10 , 12 ] and left [ 4 , 8 , 11 ] pulmonary veins. In our patient, thrombosis was observed in the left infero-posterior pulmonary vein.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report

2023

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Background Pulmonary vein thrombosis (PVT) is rarely associated with malignancies. Leiomyosarcoma, a malignant tumor originating from smooth muscles, has never been reported as the etiology of PVT. Case presentation In this case report, we described a 43-year-old Kurdish woman with a known case of leiomyosarcoma who presented with hemoptysis, dyspnea, and pleuritic chest pain. Chest computed tomography (CT) angiography revealed a thrombus in the left infero-posterior pulmonary vein. She was successfully treated with unfractionated heparin administered intravenously followed by orally administered warfarin. At the end of the article, we describe and compare other reports of malignancy-related PVT. Conclusions While malignancies are not a common cause of PVT, both primary lung tumors and metastatic cancers could be associated with PVT. Delay in diagnosis may lead to serious complications and even death. Therefore, clinicians should be aware of the possibility of the development of PVT in different malignancies for appropriate diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

“…The remaining patients had metastatic cancers with different origins. In six cases [ 5 – 7 , 9 , 10 , 12 ], the thrombus was located at the branches of the right pulmonary vein. In the other four cases, including the present case, it was located at the branches of the left pulmonary vein [ 4 , 8 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report

2023

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“…PVT is a rare but potentially life-threatening condition with unclear incidence, as much of the literature stems from case reports [1][2][3][4][5][6]. In the published literature, PVT has most commonly been associated as a known complication of pulmonary lobectomy, lung transplant, radiofrequency ablation, and extracorporeal membrane oxygenation (ECMO), with rare reported cases of primary and secondary lung tumors.…”

Section: Discussionmentioning

confidence: 99%

“…While PVT has been associated with metastatic follicular thyroid carcinoma, renal cell carcinoma, small intestine mantle cell lymphoma, osteosarcoma, and liposarcoma in rare case reports, there is a lack of understanding regarding pathophysiology and mechanism of thrombosis in the pulmonary veins, with only proposed theories of potential extrinsic compression, endothelial disruption, hypercoagulability of malignancy, or direct tumor extension into the venous system [2]. Furthermore, there are no clear diagnostic criteria, gold standard imaging modality of choice, or therapeutic recommendation for the diagnosis and management of PVT in malignancy [3][4][5][6][7]. With this said, our case report of metastatic MFS as a cause of PVT provides another unique data point to the large disparity in current literature, with the hope that compilation of case reports can eventually lead to standard diagnostic and therapeutic recommendations.…”

Section: Discussionmentioning

confidence: 99%

A Unique Presentation of Pulmonary Vein Thrombosis in a Patient With Rapidly Progressive Metastatic Pelvic Myxofibrosarcoma

Leonhardt¹,

Pervez²,

Tang³

et al. 2022

Cureus

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Pulmonary vein thrombosis (PVT) is an uncommon but often lethal disease with non-specific manifestations. Herein, we present a case of an elderly woman with a past medical history significant for limited-stage pelvic myxofibrosarcoma (MFS), who was admitted with subacute weakness and worsening dyspnea. Over the course of hospitalization, CT angiography was performed, which demonstrated a filling defect in the inferior left pulmonary vein consistent with PVT, in addition to evidence of widespread metastatic disease. The patient was offered therapeutic anticoagulation, but given the extent of her metastasis, the patient opted to transition to comfort care and pursued hospice care. This case serves as a unique presentation of a rare disease process associated with widespread metastatic MFS, illustrating the need for early recognition and treatment.

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“…Most of the patients are asymptomatic or have nonspecific symptoms such as cough, hemoptysis, weight loss, and dyspnea as a result of pulmonary edema or infarction [3][4]. In cases associated with lung cancer the hypothesized underlying mechanism seems to involve either of the following: direct extension of the primary lung tumor into the pulmonary vein or mechanical compression over the pulmonary vein, as well as the prothrombotic state associated with the malignancy itself contributing to the formation of a thrombus [1,[4][5]. Complications, described previously in the literature that are associated with PVT include pulmonary infarction, pulmonary edema, systemic embolization (e.g.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Vein Tumor Thrombus With Intracardiac Extension Secondary to Poorly Differentiated Bronchogenic Carcinoma

Faiek¹,

Malik²,

Farquhar³

et al. 2020

Cureus

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Pulmonary vein thrombosis (PVT) is a rarely encountered disease entity with varied clinical presentations. It has been reported to be associated with underlying lung malignancy in multiple case reports. Diagnosis can be challenging due to nonspecific symptoms on presentation. Herein, we report a 67-year-old male patient with a history of extensive smoking and chronic obstructive pulmonary disease (COPD) who presented with multiple hemoptysis episodes. CT scan of the chest with contrast showed multiple right lower lobe (RLL) lung masses and a thrombus in the inferior pulmonary vein. After various imaging modalities and transthoracic biopsy of the lung mass, the patient was diagnosed with pulmonary vein tumor thrombus secondary to poorly differentiated bronchogenic carcinoma with intracardiac extension. The patient was started on Eliquis for anticoagulation and is currently in the process of beginning chemo/radiation therapy for the underlying malignancy.

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Pulmonary Vein Thrombosis Associated with Metastatic Follicular Thyroid Carcinoma: A Case Report and Review

Abstract: Pulmonary vein thrombosis (PVT) mainly occurs following lung transplantation but cases associated with thoracic malignancy have also been described. We describe here the first case of PVT in an asymptomatic patient with metastatic follicular thyroid carcinoma.

Cited by 4 publications

References 18 publications

Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report

Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report

A Unique Presentation of Pulmonary Vein Thrombosis in a Patient With Rapidly Progressive Metastatic Pelvic Myxofibrosarcoma

Pulmonary Vein Tumor Thrombus With Intracardiac Extension Secondary to Poorly Differentiated Bronchogenic Carcinoma

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