Pulmonary tissue volume in dogs during pulmonary edema

Peterson, Barry T.; Petrini, Marcy F.; Hyde, Richard W.; Schreiner, Bernard F.

doi:10.1152/jappl.1978.44.5.782

Cited by 50 publications

(32 citation statements)

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“…The combination of these other estimates gives a volume of blood and tissue of about 700 ml for our subjects. The agreement with our estimate is quite close, although the data of Peterson et al (1978) and Petrini et al (1978) (SD 0-42 1). These differences may provide a useful index of inhomogeneity of ventilation or gas "trapping" in subjects with airways obstruction, and the combination of radiographic and gas dilution techniques permits such measurements to be made without a body plethysmograph.…”

Section: Discussionsupporting

confidence: 88%

Estimation of lung volumes from chest radiographs using shape information.

Pierce¹,

Brown²,

Holmes³

et al. 1979

Thorax

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The cross-sectional shapes of the chest and its contained structures have been assessed in post-mortem anatomical sections and from computerised tomographic scans in living subjects. These shapes are described by simple equations that can be used to increase the accuracy of measuring lung volumes from chest radiographs. Radiographic estimates of total lung capacity, using the equations, were compared with plethysmographic and single-breath helium dilution measurements in 35 normal subjects. The postures commonly used for taking chest radiographs were found, on average, to decrease total lung capacity (TLC) and to increase residual volume by about 200 ml when compared with the sitting positions used for the other two measurements (studies made in 18 of the subjects). After correction for this effect, the radiographic estimates of TLC, which measure the displacement volume of the lung, exceeded the plethysmographic estimates of contained gas volume by a mean of 720 ml, which was taken as the volume of tissue, blood, and water in the lungs. The single-breath dilution estimates of TLC fell short of the plethysmographic values by a mean of 480 ml, taken as the volume of contained gas that was inaccessible to helium in 10 seconds. The tomographic studies suggested that the radiographic technique of measuring lung displacement volumes has an accuracy of +210 ml. The method is rapid and simple to use and has intra-and inter-observer variabilities of <1% and <5% respectively. Barnhard et al (1960) assumed that each lung and the heart were elliptical in cross-section and considered the diaphragm as one-eighth of an ellipsoid. All these methods are dependent for their accuracy on correlations with other methods of measuring lung volume, such as plethysmography or gas dilution. The acceptability of the plethysmograph as a standard for comparison is not entirely above suspicion, especially in patients with lung disease: recent studies by Brown et al (1978b) have suggested that airways obstruction may lead to inaccurate measurement. Previous studies have also neglected the effects of postural differences on static lung volumes, and have applied a single approximate magnification factor to all radiographs.The

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Section: Discussionsupporting

confidence: 88%

Estimation of lung volumes from chest radiographs using shape information.

Pierce¹,

Brown²,

Holmes³

et al. 1979

Thorax

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“…In this acute lung injury model, whose collateral ventilation is similar to humans (8), our findings of decreased FRC and underestimation of VTPC at zero end expiratory pressure after induction of lung edema suggests loss of gas exchange units secondary to the oleic acid-induced injury, with inability of the test gas to reach these involved units. Dogs, in which most of the previous studies of the applicability of rebreathing methodology in pulmonary edema have been performed (9,10,16), have a much more developed degree of collateral ventilation. This possibly explains the better correlation of VTPC with gravimetric lung water without the application of PEEP in dogs with lung injury (10,16).…”

Section: Discussionmentioning

confidence: 99%

“…Dogs, in which most of the previous studies of the applicability of rebreathing methodology in pulmonary edema have been performed (9,10,16), have a much more developed degree of collateral ventilation. This possibly explains the better correlation of VTPC with gravimetric lung water without the application of PEEP in dogs with lung injury (10,16). The application of PEEP (up to 10 cm H20) following oleic acid lung injury resulted in a significant increase of FRC indicating lung expansion.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Cardiopulmonary Function by Rebreathing Methodology in Piglets

1984

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“…pulmonary capillary blood flow (Qc), re breathing techniques have been developed to calculate these values using rapid-re sponse mass spectrometers. Two different ways of measuring have usually been used: the method called multiple-point zero forcing (MPZF) proposed by Sackner et al [22], and the end-tidal, dead-space cor rection (ETDS) method proposed by Pe terson et al [ 17] and Petrini et al [ 18]. Stud ies carried out to determine the influence of experimental and measurement vari ables [17,18,20,23], correlation with post mortem morphometric studies [4], reprod ucibility of the results [4], and application in lung edema [9,17] have demonstrated that this technique is a useful tool in exper imental work and has possible clinical ap plications.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Parenchymal Tissue Volume and Pulmonary Capillary Blood Flow in Normal Subjects

Mangado¹,

Mir²,

Peces-Barba³

et al. 1986

Respiration

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We measured pulmonary parenchymal tissue volume (Vt) and pulmonary capillary blood flow (Qc) in 11 normal subjects by a rebreathing technique and end-tidal, dead-space correction (ETDS) method, using two soluble gases, acetylene (C₂H₂) and dimethyl ether (DME). We assessed the results using different intervals of measurement, inspired volumes and rebreathing frequencies. The mean values ± SD of Vt were 559 ± 58 and 511 ± 52 ml, with C₂H₂ and DME, and of Qc were 3.67 ± 0.44 and 4.18 ± 0.54 liter/min/m², respectively. Measurements with the interval between the 1st and the 6th end-tidal points and within the first 15 s yielded the best reproducibility. Data obtained from two satisfactory recordings from the same subject are sufficient to calculate Vt and Qc. Inspired volume shows a significant correlation with Vt values measured with both tracer gases, especially with DME. Rebreathing frequency also affects this latter gas. Despite some problems which are not easily explainable (dependence upon the inspired volume, rebreathing frequency and test gas species), we conclude that the methods allow measurements of Vt and Qc with acceptable reproducibility but that different variables may affect the results

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Pulmonary tissue volume in dogs during pulmonary edema

Cited by 50 publications

References 0 publications

Estimation of lung volumes from chest radiographs using shape information.

Estimation of lung volumes from chest radiographs using shape information.

Measurement of Cardiopulmonary Function by Rebreathing Methodology in Piglets

Pulmonary Parenchymal Tissue Volume and Pulmonary Capillary Blood Flow in Normal Subjects

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