Pulmonary Strategies of Antioxidant Defense

Heffner, John E.; Repine, John E.

doi:10.1164/ajrccm/140.2.531

Cited by 518 publications

(314 citation statements)

References 106 publications

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“…Vitamin C can directly scavenge O 2 . -and • OH with the formation of semidehydroascorbate-free radical that is subsequently reduced by GSH to generate dehydroascorbate and GS and it can also neutralize several oxidants present in the blood of smokers (11). In the present study, it was found that concentration of vitamin C significantly decrease in patients with COPD, emphysema and bronchiectasis, but was comparable in patients with Bronchial asthma to that of control group.…”

Section: Resultssupporting

confidence: 51%

Plasma oxidant-antioxidant status in different respiratory disorders

Raghunath

Phadke

2006

Indian J Clin Biochem

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Section: Resultssupporting

confidence: 51%

Plasma oxidant-antioxidant status in different respiratory disorders

Raghunath

Phadke

2006

Indian J Clin Biochem

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“…The pulmonary alveolar space is exposed to relatively high tensions of oxygen. Despite a variety of protective mechanisms, breathing high concentrations of oxygen for extended periods of time results in acute lung injury (31,32). The sequence of events leading to acute lung injury after exposure to hyperoxia has been described in several different models and the focus of most studies has been on the endothelial cells and epithelial cells of the alveolar wall (7-9, 11, 12).…”

Section: Discussionmentioning

confidence: 99%

Sublethal Hyperoxia Impairs Pulmonary Innate Immunity

Baleeiro

Wilcoxen

Morris

et al. 2003

The Journal of Immunology

108

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Supplemental oxygen is often required in the treatment of critically ill patients. The impact of hyperoxia on pulmonary host defense is not well-established. We hypothesized that hyperoxia directly impairs pulmonary host defense, beyond effects on alveolar wall barrier function. C57BL/6 mice were kept in an atmosphere of >95% O2 for 4 days followed by return to room air. This exposure does not lead to mortality in mice subsequently returned to room air. Mice kept in room air served as controls. Mice were intratracheally inoculated with Klebsiella pneumoniae and followed for survival. Alveolar macrophages (AM) were harvested by bronchoalveolar lavage after 4 days of in vivo hyperoxia for ex vivo experiments. Mortality from pneumonia increased significantly in mice exposed to hyperoxia compared with infected mice in room air. Burden of organisms in the lung and dissemination of infection were increased in the hyperoxia group whereas accumulation of inflammatory cells in the lung was impaired. Hyperoxia alone had no impact on AM numbers, viability, or ability to phagocytize latex microbeads. However, following in vivo hyperoxia, AM phagocytosis and killing of Gram-negative bacteria and production of TNF-α and IL-6 in response to LPS were significantly reduced. AM surface expression of Toll-like receptor-4 was significantly decreased following in vivo hyperoxia. Thus sublethal hyperoxia increases Gram-negative bacterial pneumonia mortality and has a significant adverse effect on AM host defense function. Impaired AM function due to high concentrations of supplemental oxygen may contribute to the high rate of ventilator-associated pneumonia seen in critically ill patients.

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“…Antioxidant vitamins are generally thought to protect tissue from oxidant cellular injury, partly through their ability to quench reactive molecules (Heffner andRepine, 1989, Palace et al, 1999). Population-based studies support this notion, given that a majority of these studies report positive associations of pulmonary function and antioxidant vitamins.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

et al. 2006

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Objective: The objective of this study was to investigate the association between antioxidant nutrients and markers of oxidative stress with pulmonary function in persons with chronic airflow limitation. Design: Cross-sectional study exploring the association of antioxidant nutrients and markers of oxidative stress with forced expiratory volume in the first second (FEV 1 %) and forced vital capacity (FVC%). Setting/Subjects: The study data included 218 persons with chronic airflow limitation recruited randomly from the general population of Erie and Niagara counties, New York State, USA. Results: After adjustment for covariates, multiple linear regression analysis showed that serum b-cryptoxanthin, lutein/ zeaxanthin, and retinol, and dietary b-carotene, b-cryptoxanthin, lutein/zeaxanthin, vitamin C, and lycopene were positively associated with FEV 1 % (Po0.05, all associations). Serum vitamins b-cryptoxanthin, lutein/zeaxanthin, and lycopene, and dietary b-cryptoxanthin, b-carotene, vitamin C, and lutein/zeaxanthin were positively associated with FVC% (Po0.05, all associations). Erythrocytic glutathione was negatively associated with FEV 1 %, while plasma thiobarbituric acid-reactive substances (TBARS) were negatively associated with FVC% (Po0.05). Conclusion: These results support the hypothesis that an imbalance in antioxidant/oxidant status is associated with chronic airflow limitation, and that dietary habits and/or oxidative stress play contributing roles.

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Pulmonary Strategies of Antioxidant Defense

Cited by 518 publications

References 106 publications

Plasma oxidant-antioxidant status in different respiratory disorders

Plasma oxidant-antioxidant status in different respiratory disorders

Sublethal Hyperoxia Impairs Pulmonary Innate Immunity

Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

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