Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

Ochs‐Balcom, Heather M.; Grant, Brydon J. B.; Muti, Paola; Sempos, Christopher T.; Freudenheim, Jo L.; Browne, Richard W.; McCann, Susan E.; Trevisan, Maurizio; Cassano, Patricia A.; Iacoviello, Licia; Schünemann, Holger J.

doi:10.1038/sj.ejcn.1602410

Cited by 137 publications

(114 citation statements)

References 29 publications

(39 reference statements)

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“…Our findings indicate a significant increase in both systemic oxidative stress markers (8-OHdG, MDA and AOPP) and increased antioxidant enzyme activity (GPX) in COPD patients compared with healthy control subjects, and are in similar agreement with other published data [28][29][30][31]. In contrast to our results, increased glutathione has previously been shown to be negatively correlated with lung function in patients with chronic airflow limitation [30]. We suspect that there may be an adaptive response involved in the oxidative stress-antioxidant enzyme response, and that the high level of oxidants stimulates the antioxidant enzymatic system in an effort to counteract the high burden of oxidants.…”

Section: Molecular Markerssupporting

confidence: 82%

“…In addition to endogenous sources of ROS (normal cellular metabolism), COPD patients are exposed to exogenous forms of free radicals from environmental pollutants and/or cigarette smoke. Our findings indicate a significant increase in both systemic oxidative stress markers (8-OHdG, MDA and AOPP) and increased antioxidant enzyme activity (GPX) in COPD patients compared with healthy control subjects, and are in similar agreement with other published data [28][29][30][31]. In contrast to our results, increased glutathione has previously been shown to be negatively correlated with lung function in patients with chronic airflow limitation [30].…”

Section: Molecular Markerscontrasting

confidence: 57%

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Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Hartmann¹,

Pialoux²,

Leigh³

et al. 2012

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) is associated with cerebrovascular abnormalities and an overproduction of reactive oxygen species. We hypothesised that COPD patients have oxidant-related cerebrovascular dysfunction. Our main objective was to evaluate cerebrovascular reactivity and its relationship with oxidative stress in females with COPD.We studied eight females with moderate COPD and 10 healthy female control subjects of similar age. Transcranial Doppler ultrasound assessed cerebral blood flow (CBF) velocity during hypercapnia. Plasma was assessed at rest for DNA oxidation, advanced oxidation protein products, lipid peroxidation, nitrotyrosine, antioxidant enzyme activity (glutathione peroxidase and catalase) and end-products of nitric oxide metabolism.Moderate COPD patients showed decreased cerebrovascular sensitivity to carbon dioxide (CO 2 ) (COPD 1.17¡0.54 versus control 2.15¡0.73 cm?s -1 ?mmHg -1 ; p,0.01). COPD patients had higher levels of DNA and lipid oxidation, advanced oxidation protein products and higher glutathione peroxidase activity (p,0.05). Controlling for measures of oxidative stress (DNA and lipid oxidation, and advanced oxidation protein product) eliminates statistically significant differences between the COPD and control groups in the CBF sensitivity to CO 2 . Females with moderate COPD were found to have cerebrovascular dysfunction. Our results suggest that increased levels of systemic oxidative stress may have implications in the cerebrovascular dysfunction observed during hypercapnia in COPD.

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Section: Molecular Markerssupporting

confidence: 82%

Section: Molecular Markerscontrasting

confidence: 57%

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Hartmann¹,

Pialoux²,

Leigh³

et al. 2012

Eur Respir J

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“…Vitamin C (ascorbic acid) is a water-soluble, chain-breaking antioxidant, which scavenges aqueous superoxide radicals and has multiple antioxidant properties. Reductions in serum vitamin C concentrations were recently shown to be related to the severity of obstructive lung impairment in COPD (Ochs-Balcom, 2006). This finding supports the hypothesis that the oxidant/antioxidant imbalance is associated with chronic airflow limitation.…”

Section: Non-enzymatic Antioxidantssupporting

confidence: 79%

The role of oxidative stress in lung injury induced by cigarette smoke

Kluchová

Tkáčová

2006

Biologia

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Oxidative stress is a damaging process resulting from an imbalance between excessive generation of oxidant compounds and insufficient antioxidant defence mechanisms. Oxidative stress plays a crucial role in the initiation and progression of cigarette smoke-induced lung injury, deterioration in lung functions, and development of chronic obstructive pulmonary disease (COPD). In smokers and in patients with COPD, the increased oxidant burden derives from cigarette smoke per se, and from activated inflammatory cells releasing enhanced amounts of reactive oxygen and nitrogen species (ROS, RNS, respectively). Although mild oxidative stress resulting from cigarette smoking leads to the upregulation of the antioxidative enzymes synthesis in the lungs, high levels of ROS and RNS observed in patients with COPD overwhelm the antioxidant enzymes capacities, resulting in oxidant-mediated lung injury and cell death. In addition, depletion of antioxidative systems in the systemic circulation was consistently observed in such patients. The imbalance between the generation of ROS/RNS and antioxidant capacities -the state of "oxidative stress" -is one of the major pathophysiologic hallmarks in the development of COPD. Detrimental effects of oxidative stress include impairment of membrane functions, inactivation of membrane-bound receptors and enzymes, and increased tissue permeability. In addition, oxidative stress aggravates the inflammatory processes in the lungs, and contributes to the worsening of the protease-antiprotease imbalance. Several markers of oxidative stress, such as increases in lipid peroxidation products and reductions in glutathione peroxidase activity, have been shown to be related to the reductions in pulmonary functions. In the present article we review the current knowledge about the vicious cycle of cigarette smoking, oxidative stress, and inflammation in the pathogenesis of COPD.

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“…Again, antioxidant capacity in serum is reduced in asthmatics during exacerbations as compared with healthy individuals and is less reduced in subjects with stable asthma (Katsoulis et al, 2003). Very recently, oxidative stress has been shown to be increased in children with previous bronchilitis obliterans (Mallol et al, 2011) and although in this study the authors did not find correlation with lung function tests, several studies have indeed shown an inverse relationship between oxidative stress and lung function in asthmatics (Nadeem et al, 2005;Ochs-Balcom et al, 2006;Picado et al, 2001;Wood et al, 2000). Taken together these results indicate that an oxidant-antioxidant imbalance could play a crucial role in the development of asthma symptoms and in the severity of the disease.…”

Section: Diet As An Independent Factor In the Development Of Asthma Acontrasting

confidence: 55%

Obesity, Diet, Exercise and Asthma in Children

García‐Marcos¹,

Sánchez-Solís²

2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

Cited by 137 publications

References 29 publications

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

The role of oxidative stress in lung injury induced by cigarette smoke

Obesity, Diet, Exercise and Asthma in Children

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Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

Cited by 137 publications

References 29 publications

Decreased cerebrovascular response to CO2in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO2in post-menopausal females with COPD: role of oxidative stress

The role of oxidative stress in lung injury induced by cigarette smoke

Obesity, Diet, Exercise and Asthma in Children

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Product

Resources

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Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress

Decreased cerebrovascular response to CO₂in post-menopausal females with COPD: role of oxidative stress