Plasma oxidant-antioxidant status in different respiratory disorders

Raghunath, Raghu; Phadke, Madhavi S.

doi:10.1007/bf02912934

Cited by 49 publications

(44 citation statements)

References 10 publications

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“…However, we found a dramatic increase in SOD and CAT activities among patients with more severe COPD. It was found that erythrocyte SOD and CAT activities gradually increased from GOLD stages I to IV in COPD patients, which is supported by previous reports [36][37][38][39][40][41]. Indeed, various studies [40][41][42] except one study [7] have suggested that certain markers of oxidative stress may be related to tobacco smoking or to the severity of COPD.…”

Section: Discussionsupporting

confidence: 75%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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Background: Oxidative stress has been suggested in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) with an additional burden of diabetes, hypertension and cardiovascular disease. In the present study, we investigated erythrocyte antioxidant enzymes activities in correlation to COPD severity and COPD comorbidities. Methods: One hundred twenty seven subjects with COPD and 59 healthy controls participated in this study. COPD severity was done based on the Global Initiative for Chronic Obstructive Lung Disease criteria. The erythrocytes enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS) were measured with spectrophotometric method. Results: COPD patients showed significant decrease in TAS (p > 0.05), GST (p < 0.001) and GPx (p < 0.01) activities with progression of the disease. In patients, FEV 1 was negatively correlated with SOD, GR and positively correlated with GST and GPx activities. Further, multivariate logistic regression analysis revealed GST (OR = 0.93; 95% CI = -0.10 -0.01; p < 0.01) , GPx (OR = 0.98; 95% CI = -0.03 -0.00; p < 0.05) and TAS (OR = 0.95; 95% CI = -0.08 -0.00; p < 0.05) were independently associated with FEV 1 in GOLD stage IV and GST (OR = 1.11; 95% CI = 0.04-0.18; p < 0.001) in GOLD stage II. Regression analysis confirmed a significant difference in GPx activity in COPD -type 2 diabetes (OR = 0.04; 95% CI = -6.60 -0.53; P = 0.09), and GST activity in COPD -cardiovascular disease (OR = 2.51; 95% CI = 0.00 -1.84; p < 0.05) patients when compared to patients without comorbidities. Conclusion: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between GST and GPx with COPD severity. Our results also indicate that erythrocytes GST and GPX activities are significantly associated with comorbidities, but only in COPD patients with type 2 diabetes and cardiovascular disease.

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Section: Discussionsupporting

confidence: 75%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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“…In the present study as shown in TABLE 1 levels of non-enzymatic antioxidants ,Vitamin C ,vitamin E and β carotene are significantly low in cases diagnosed with pneumonia as compared to control group along with increase in MDA level as shown in TABLE 2 .Similar results were shown by Cemek M et al [8]Rai RR, Phadke MS [13]. These antioxidants are acting as lipid peroxidation chain breaking molecules and scavengers to reduce the oxidative stress.…”

Section: Discussionsupporting

confidence: 86%

Antioxidant enzymes and antioxidants in children with Pneumonia

Vaidya¹,

Bulakh²

2013

IOSR-JDMS

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“…Tuberculosis is prooxidant state as active inflammation involves activated inflammatory cells that secrete cytokines and free radicals. There is progressive decline in plasma antioxidant activity and increasing oxidative stress causing organ damage including liver in TB patients [6,7] . Elevation of trasaminases is seen more frequently and more markedly in slow acetylators.…”

Section: Antitubercular Drug Induced Hepatotoxicity (Att-dih)mentioning

confidence: 99%

Liver Dysfunction in Pulmonary Tuberculosis Patients on DOTS: A Study and Review

Pandit

Pandey

2016

Journal of Gastroenterology and Hepatology Research

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eGFR were done. Development of hepatotoxicity was watched by monthly monitoring of liver enzymes and bilirubin serum profiles. RESULT: The selected 148 patients were older and four fifths were males. 16 patients developed ATT-DIH at first or second month monitoring following DOTS. They were more undernourished, hypoproteinaemic, bore more extensive disease and were sputum AFB positive. Their eGFR profiles were normal but significantly lower and plasma antioxidant capacity significantly reduced. Oxidative stress marker levels also were insignificantly raised. They exhibited subclinical elevation of serum enzymes AST and ALT. No significant influence of age and gender was seen on incidence of ATT-DIH. CONCLUSION: Frailty with extensive disease constituted phenotype vulnerable to ATT-DIH. Hypoalbuminaemia, reduced plasma antioxidant capacity, subclinical elevated profile of transaminases before starting DOTS were forewarning laboratory indices. LFT ought to be monitored at fortnight, a month and at 2 months in such patients as minimum necessity to timely detect and address hepatotoxicity. INTRODUCTIONTuberculosis continues as huge health care problem globally. Currently recommended first line treatment for TB includes regimen of isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) and ethambutol (EMB) for initial 2 months followed by 4 months of INH and RMP and/or EMB [1] . Among the first line quadruple therapy drugs (INH, RMP, PZA, EMB), first three are metabolized mainly by the liver and are potentially hepatotoxic. A fair fraction of TB patients on chemotherapy with isoniazide and rifampicin exhibit elevations in serum levels of liver enzymes, alanine aminotransferase (ALT, earlier called SGPT) and aspartate aminotransferase (AST, earlier SGOT) activities. A small fraction of these can worsen further to compel ABSTRACT CONTEXT: Phenomenal number of people suffers tuberculosis and is prescribed primary line DOTS antitubercular chemotherapy. Evidence based clinical practice to minimize risk of hepatotoxicity is primary imperative. AIM: Study generates evidence for predicting individual hepatotoxic risk using patient's constitutional and health parameters and disease characteristics and adopting right course of management. It is observational study in patients consecutively selected by defined inclusion and exclusion criteria. METHODS: Newly enrolled pulmonary tuberculosis patients for DOTS were studied to examine host and disease specific predictors of hepatotoxicity risk. Pretreatment baseline liver function tests and

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Plasma oxidant-antioxidant status in different respiratory disorders

Abstract: ABSTRACT

Cited by 49 publications

References 10 publications

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Antioxidant enzymes and antioxidants in children with Pneumonia

Liver Dysfunction in Pulmonary Tuberculosis Patients on DOTS: A Study and Review

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