Pulmonary Meningioma: <i>Report of a Case with Electron Microscopic and Immunohistochemical Findings</i>

Robinson, Philip G.

doi:10.1093/ajcp/97.6.814

Cited by 21 publications

(12 citation statements)

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“…The histogenesis of ectopic meningiomas was not entirely clear. It is believed that these tumors are derived from ectopic arachnoid cell [7] or from mesenchymal cells or Schwann cells, which have been differentiated into meningothelial cells [8].…”

Section: Discussionmentioning

confidence: 99%

Primary mediastinal malignant meningioma

Yang

Gào²,

Wang³

2009

European Journal of Cardio-Thoracic Surgery

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Primary ectopic meningiomas are extremely rare tumors of controversial origin and they are usually limited to the head and neck region. Its occurrence at the mediastinum is even rarer. There has not been any official report regarding primary mediastinal malignant meningioma until today. Because of its rarity and potential value, we report here a case of primary mediastinal malignant meningioma, which turns out to be the first reported case of this type of meningioma. The clinical features, treatment plans, pathological findings, as well as prognosis of a case of primary mediastinal malignant meningioma were carefully analyzed and the literature on ectopic meningioma was reviewed. The diagnosis of ectopic meningioma can only be established based on microscopic and immunohistochemical findings. Surgery is the treatment of choice for ectopic meningioma and postoperative radiotherapy should be managed for patients with suspected invasive meningioma.

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Section: Discussionmentioning

confidence: 99%

Primary mediastinal malignant meningioma

Yang

Gào²,

Wang³

2009

European Journal of Cardio-Thoracic Surgery

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“…In the head and neck region, these tumors are often associated with cranial nerves and appear to be derived from ectopic arachnoid tissue (2,31). It has been suggested that ectopic lung meningiomas arise from ectopic arachnoid cells (17,32) or from mesenchymal cells or Schwann cells that have differentiated into meningothelial cells (24). Recent studies have shown that arachnoid cells and perineurial cells, commonly expressing EMA, may be embryologically and functionally related (33).…”

Section: Discussionmentioning

confidence: 99%

Primary Extracranial Meningioma of the Foot: A Case Report

Tomaru¹,

Hasegawa²,

Hasegawa³

et al. 2000

Japanese Journal of Clinical Oncology

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We present a rare case of primary extracranial meningioma in a 36-year-old man, who had a solitary multinodular mass located in the plantar muscle of the foot. The histology of specimens from simple excision was typical of meningioma, showing bland spindle cell proliferation with a whorl pattern. Immunohistochemical analysis demonstrated that the tumor cells showed diffuse and strong positivity for epithelial membrane antigen as well as moderate reactivity for cytokeratin and vimentin. Ultrastructurally, the tumor cells were characterized by thin bipolar cytoplasmic processes and joined by multiple small desmosomes. There were frequent pinocytotic vesicles and a distinct external lamina on the cell surface. These findings suggest that this primary ectopic meningioma, arising in the soft tissue, may have been derived from perineurial cells of the peripheral nerve, but was morphologically distinguishable from perineurioma. Primary extracranial meningioma should be included in the differential diagnosis of soft-tissue spindle cell tumors, especially those of peripheral nerve origin.

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“…3 In previously published reports of benign ectopic meningiomas, the histogenesis was discussed and four theories advocated: (1) meningiomas are direct extensions of primary intracranial tumor, (2) they are extracranial growths of arachnoid cells located along the cranial nerve sheaths, (3) they are proliferations of ectopic embryonic nests of arachnoid cells, and (4) they are extracranial metastases from benign-appearing primary intracranial meningiomas. 2,5,7,10,14,16 …”

Section: Discussionmentioning

confidence: 99%

“…15 Only 11 cases of primary pulmonary benign meningioma have been described since Kemnitz et al reported the first in 1982. 2,[4][5][6]8,10,13,14,16 The present paper documents the first case of multicentric meningioma arising bilaterally in the lungs and diagnosed by imprint cytology. Included is a review of the cytologic, histologic, immunohistochemical and ultrastructural features of the previous cases with particular reference to cytologic differential diagnosis and histogenesis.…”

Section: Primary Pulmonary Meningiomamentioning

confidence: 98%