Cytology of Primary Pulmonary Meningioma

Ueno, Makoto; Fujiyama, Junzo; Yamazaki, Ieharu; Uchiyama, Takashi; Ishikawa, Yuichi; Satoh, Yukitoshi

doi:10.1159/000332179

Cited by 26 publications

(15 citation statements)

References 8 publications

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“…Our patient (case 4) with multiple scalp lesions had a prior brain meningioma. Although primary heterotopic meningeal proliferations do occur in the lung [22,30], in our study the tumor encountered in the lung represented a metastasis. Our data show that most ectopic extracranial meningiomas were low-grade neoplasms, whereas metastatic tumors demonstrated more high-grade features.…”

Section: Discussionmentioning

confidence: 84%

“…Although the cytomorphology of squashed intracranial meningiomas have been well described for intraoperative neuropathology consultations involving these tumors [1,8], the cytological findings of extracranial meningiomas have been limited to case reports. Primary ectopic meningiomas diagnosed by fine-needle aspiration (FNA) have been reported in the head and neck [9,10,11,12,13,14], orbit [15,16,17,18], bone [19], skin [20] and lung [21,22]. Metastatic meningiomas diagnosed by FNA have been documented in the lung [11,23,24,25,26], liver [27] and soft tissues [28].…”

Section: Introductionmentioning

confidence: 99%

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Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

et al. 2013

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Introduction: Extracranial meningiomas may infrequently be encountered as ectopic or metastatic tumors. Their rarity and unique cytomorphology often pose significant diagnostic dilemmas. The aim of this study was to report our experience with a series of ectopic and metastatic meningiomas, characterizing their cytomorphology with histological correlation. Materials and Methods: A retrospective analysis involving 13 patients with cytological preparations from extracranial meningiomas was performed. Cytology cases were correlated with available surgical resection specimens. Data regarding clinical findings, tumor information, cytomorphology, follow-up histological features and immunohistochemistry were recorded and analyzed. Results: There were 5 cases with metastases and 8 ectopic meningiomas. Metastases occurred in the scalp/skull, lung, paraspinal soft tissue and liver. Primary ectopic meningiomas were located in the paranasal sinuses and ear, orbit and neck. Cytomorphological features characteristic of meningiomas were identified in the majority of samples including tightly cohesive clusters of spindled cells, whorls, intranuclear inclusions, nuclear grooves and psammomatous calcification. Unusual cytomorphological features identified in only a few cases included epithelioid cell predominance, abundant inflammatory cells, small-cell change, papillary structures and pseudoacinar growth. Metastatic tumors exhibited more nuclear atypia and occasionally mitoses or necrosis. Meningiomas were shown to be immunoreactive for epithelial membrane antigen, pancytokeratin and vimentin. Conclusion: Although rare, extracranial meningiomas can be encountered in cytologic specimens and should be included in the differential diagnosis when characteristic morphological features of meningiomas are seen. Cytopathologists should be aware that these lesions could be mistaken for other tumors, especially when confounded by atypia and unusual cytomorphological features.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

et al. 2013

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“…Histologically, the tumor consists of whorled www.onk.ns.ac.rs/Archive Vol 17, No. 1-2, July 2009 nests of spindle to ovoid cells accompanied by psammoma bodies and immunohistochemically it shows positivity for EMA and vimentin and negative or variable expression for keratin, desmin and S-100 protein (14)(15)(16)(17)(18). That is the reason why the differential diagnosis of MPMNs includes primary pulmonary meningioma.…”

Section: Discussionmentioning

confidence: 99%

Minute pulmonary meningothelial-like nodules simulating a metastatic lung adenocarcinoma: A case report

et al. 2009

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Minute pulmonary meningothelial-like nodules (MPMNs) are relatively rare lesions that located at the pleura or parenchyma of the lung. They are usually found incidentally at autopsy or in surgical specimens. We presented a case of asymptomatic 47-year-old woman with an abnormal shadow in the right upper lung field found by a routine chest X ray. A computed tomography (CT) scan of the thorax revealed a hyperdense subpleural mass, which histologically conformed to adenocarcinoma. A resection of the right upper lobe discovered preponderance of small multiple lesions under the pleura. Microscopically, they were an interstitial nodular proliferation of oval or spindle-shape cells arranged in a zellenballen nesting pattern near small veins. Immunohistochemical and cytological analyses confirmed the diagnosis of MPMNs. Coexistence of multiple MPMNs and lung adenocarcinoma can be a differential diagnostic problem due to suspected metastasis of the primary carcinoma. To obtain an accurate diagnosis, the clinical findings should completely conform to histological, immunohistochemical, and cytological ones

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“…In 1998, we reported the first multiple case of primary pulmonary meningiomas (PPMs), extremely rare lung neoplasms [1]. Then in 2010, we also reported the additional clinical course in the initial case 10 years after surgery implying a benign biological nature [2].…”

Section: Introductionmentioning

confidence: 99%

“…There have been fewer than 50 cases of PPMs reported in the literature to date [3], [4]. Although the lesions are widely known most likely to be benign, grow slowly, and have an excellent prognosis, the etiology is still uncertain; and hence, several mechanisms have been proposed [1], [4], [5], [6], [7], [8]. Here, we present an additional extremely long course of the initial multiple case of PPM, 20 years after surgery, with further examination by imaging modalities in a specialized institution and then confirm particularly its being benign in nature.…”

Section: Introductionmentioning

confidence: 99%

Multiple primary pulmonary meningiomas: 20-year follow-up findings for a first reported case confirming a benign biological nature

Satoh

Ishikawa

2017

International Journal of Surgery Case Reports

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HighlightsAn 84-year-old Japanese woman with a history of multiple primary meningiomas (PPMs) we first reported.Histologically confirmed for a right-sided slowly growing lung nodule for 20 years.Long-term follow-up CT scans reveal multiple lung nodules.Multiple PPMs are most effectively treated with surgical resection and follow-up examinations.The tumors prove to be benign by morphology with a relatively long, asymptomatic clinical course.

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Cytology of Primary Pulmonary Meningioma

Cited by 26 publications

References 8 publications

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

Cytopathology of Extracranial Ectopic and Metastatic Meningiomas

Minute pulmonary meningothelial-like nodules simulating a metastatic lung adenocarcinoma: A case report

Multiple primary pulmonary meningiomas: 20-year follow-up findings for a first reported case confirming a benign biological nature

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