Primary mediastinal malignant meningioma

Yang, Xueying; Gào, Xīn; Wang, Shumin

doi:10.1016/j.ejcts.2009.03.040

Cited by 7 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…Rare examples of extracranial meningiomas arising in the mediastinum or extending into the thorax from paraspinal or intracranial lesions have been described ( 59 - 64 ).…”

Section: Benign Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

“…Distinctive features of MPNST includes hyaline bands and nodules that resemble giant rosettes. The tumors can also exhibit heterologous elements with islands of mature cartilage or bone, mucin-secreting glands, and squamous epithelium, rhabdomyosarcomatous or angiosarcomatous elements ( 64 ). Histologically, MPNST range from low-grade lesions that can be difficult to distinguish from ANNUBP, as described above, to anaplastic tumors exhibiting a markedly pleomorphic clearly sarcomatous appearance.…”

Section: Malignant Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

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Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Marchevsky¹,

Balzer²

2020

Mediastinum

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The mediastinum can be the site of origin of a variety of benign and malignant tumors of peripheral nerve sheath origin. Although schwannoma is one of the most common tumors found in the posterior mediastinum, peripheral nerve sheath tumors are reported in all compartments of the mediastinum. The majority of peripheral nerve sheath tumors in the mediastinum as in other anatomic sites occur sporadically, and a subset of them, most notably neurofibromas, and to a lesser extent, schwannomas and malignant peripheral nerve sheath tumors, occur in patients with syndromes such as neurofibromatosis 1 (NF1). In this review, the characteristics of mediastinal nerve sheath tumors along with the histologic differential diagnosis are summarized. Primary emphasis is placed upon the use of morphologic criteria for establishing a definitive diagnosis with reference to photomicrographs to illustrate the classic and sometimes unusual features of this varied group of tumors. The judicious application of ancillary testing, most frequently immunohistochemistry, for separating peripheral nerve sheath tumors from each other and from their morphologic mimics is reviewed. Included in the review are the clinicopathologic features, clinical management and prognostic implications of benign and malignant mediastinal peripheral nerve sheath tumors.

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“…Rare examples of extracranial meningiomas arising in the mediastinum or extending into the thorax from paraspinal or intracranial lesions have been described ( 59 - 64 ).…”

Section: Benign Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

Section: Malignant Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Marchevsky¹,

Balzer²

2020

Mediastinum

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“…Primary ectopic meningioma (PEM) has not been described in detail in the latest (fifth edition) World Health Organization (WHO) classification of CNS tumors ( 1 ). PEMs can occur in the ear, lung, nose, orbit, and neck ( 2 – 7 ), and PEM in the thoracic cavity is extremely rare with only a few cases in the literature ( 8 – 12 ). This tumor is easily misdiagnosed as hamartoma, thymoma, mesothelioma, or lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Primary ectopic meningioma in the thoracic cavity: A rare case report and review of the literature

Liu

Nai

et al. 2023

Front. Oncol.

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BackgroundMeningioma is a common type of intracranial tumor in adults. It rarely arises in the chest, with only a few case reports in the English literature. Here, we report the case of a patient with a primary ectopic meningioma (PEM) located in the thoracic cavity.Case presentationA 55-year-old woman presented with exercise-induced asthma, chest tightness, intermittent dry cough and fatigue for several months. Computed tomography revealed the presence of a huge mass in the thoracic cavity, with no connection to the spinal canal. Lung cancer and mesothelioma were suspected, and surgery was performed. Grossly, the mass was a grayish-white solid 9.5 cm × 8.4 cm × 5.3 cm in size. The microscopic morphology of the lesion was consistent with that of typical central nervous system meningioma. The pathological subtype was transitional meningioma. The tumor cells were arranged in a fascicular, whorled, storiform and meningithelial pattern, with occasional intranuclear pseudo-inclusions and psammoma bodies. In focal areas tumor cells were considerably dense, and the cells were round or irregular in shape, with less cytoplasm, uniform nuclear chromatin, and visible nucleoli and mitoses (2/10 HPF). By immunohistochemistry, the neoplastic cells showed strong and diffuse staining with vimentin, epithelial membrane antigen and SSTR2 with variable expression of PR, ALK and S100 protein. However, the cells were negative for GFAP, SOX-10, inhibin, CD34, STAT6, smooth muscle actin, desmin, CKpan, D2-40, WT-1, CK5/6 and CD45. The highest proliferation index by Ki-67 was 15%. The abnormal expression of ALK led to the initial misdiagnosis of an inflammatory myofibroblastic tumor. After 12 months of follow-up, no disease progression was observed.ConclusionThe presence of primary ectopic meningiomas in the thoracic cavity is extremely rare, and this tumor is easily misdiagnosed clinically. Imaging is suggested to determine the location and possible differential diagnosis, while the final diagnosis should be via pathological examination. Immunohistochemistry is crucial for disease diagnosis. Owing to our limited knowledge of PEM, its pathogenesis and tissue of origin remain unclear. Clinicians should pay close attention to such potential patients. The present case report may provide insights into the diagnosis and therapy of patients with this tumor.

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Treatment recommendations for primary extradural meningiomas

Mattox

Hughes

Oleson

et al. 2010

Cancer

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Highly reflective, surface‐metalized, flexible polyimide films were prepared by the incorporation of a soluble silver‐ion complex, (hexafluoroacetylacetonato)silver(I) (AgHFA), into dimethylacetamide solutions of poly(amic acid) prepared from 2,2‐bis(3,4‐dicarboxyphenyl)hexafluoropropane dianhydride and 2,2‐bis[4‐(4‐aminophenoxy)phenyl]hexafluoropropane. The thermal curing of solution‐cast silver(I)–poly(amic acid) films to 300°C led to cycloimidization of the amic acid with concomitant silver(I) reduction and the formation of a reflective, air‐side‐silvered surface at very low (2 wt % and 0.3 vol %) silver concentrations. The reflective surface evolved only when the cure temperature reached about 275°C, although X‐ray diffraction showed metallic silver in the hybrid film by 200°C. After a maximum specular reflectivity greater than 80% was achieved for the 2 wt % silver film, the specular reflectivity diminished sharply with further heating at a constant temperature of 300°C. Incorporating the AgHFA complex into the soluble, fully imidized form of poly{(1,3‐dihydro‐1,3‐dioxo‐2H‐isoindole‐2,5‐diyl)[2,2,2‐trifluoro‐1‐(trifluoromethyl)ethylidene](1,3‐dihydro‐1,3‐dioxo‐2H‐isoindole‐5,2‐diyl)‐1,4‐phenyleneoxy‐1,4‐phenylene[2,2,2‐trifluoro‐1‐(trifluoromethyl)ethylidene]‐1,4‐phenyleneoxy‐1,4‐phenylene} gave films that were 25% less reflective than those beginning with poly(amic acid). Though highly reflective, the films were not electrically conductive. The metalized membranes were thermally stable and maintained mechanical properties similar to those of the parent polyimide. Transmission electron microscopy revealed an air‐side, near‐surface layer of silver that was about 40 nm thick; the interior of the film had well‐dispersed metal particles with diameters mostly less than 2 nm. The near‐surface silver layer maintained its integrity because of physical entrapment of the metal nanoparticles beneath a thin layer of polyimide; that is, the practical adhesion of the metal layer was good. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2409–2418, 2007

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Primary mediastinal malignant meningioma

Cited by 7 publications

References 6 publications

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Primary ectopic meningioma in the thoracic cavity: A rare case report and review of the literature

Treatment recommendations for primary extradural meningiomas

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