Pulmonary infection with Penicillium citrinum in a patient with multiple myeloma

Beena, Hosdurg Bhaskar; Gupta, Megha; Kindo, Anupma Jyoti

doi:10.1016/j.ijmmb.2021.03.001

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…In view of the above, the reasons for inconsistency were determined by the expert group with reference to relevant guidelines, consensus, and literature, combined with discussion and analysis of the patient's clinical data. The reasons for this inconsistency are listed in Table 3 [14,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. More detailed information on results of routine biochemical and conventional methods have been submitted in Additional file 2.…”

Section: Inconsistency Analysis Between Mngs and Final Clinical Diagn...mentioning

confidence: 99%

Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Wang

Yang

et al. 2022

BMC Infect Dis

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Background Recently, with the rapid progress of metagenomic next-generation sequencing (mNGS), inconsistency between mNGS results and clinical diagnoses has become more common. There is currently no reasonable explanation for this, and the interpretation of mNGS reports still needs to be standardised. Methods A retrospective analysis was conducted on 47 inpatients with suspected central nervous system (CNS) infections, and clinical data were recorded. The final diagnosis was determined by an expert group based on the patient’s clinical manifestation, laboratory examination, and response to treatment. mNGS results were compared with the final diagnosis, and any inconsistencies that occurred were investigated. Finally, the credibility of mNGS results was evaluated using the integral approach, which consists of three parts: typical clinical features, positive results with the traditional method, and cerebrospinal fluid cells ≥ 100 (× 106/L) or protein ≥ 500 mg/L, with one point for each item. Results Forty-one patients with suspected CNS infection were assigned to infected (ID, 31/41, 75.61%) and non-infected groups (NID, 10/41, 24.39%) after assessment by a panel of experts according to the composite diagnostic criteria. For mNGS-positive results, 20 of the 24 pathogens were regarded as contaminants when the final score was ≤ 1. The remaining 11 pathogens detected by mNGS were all true positives, which was consistent with the clinical diagnosis when the score was ≥ 2. For mNGS negative results, when the score was ≥ 2, the likelihood of infection may be greater than when the score is ≤ 1. Conclusion The integral method is effective for evaluating mNGS results. Regardless of whether the mNGS result was positive or negative, the possibility of infection was greater when the score was ≥ 2. A negative mNGS result does not necessarily indicate that the patient was not clinically infected, and, therefore, clinical features are more important.

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Section: Inconsistency Analysis Between Mngs and Final Clinical Diagn...mentioning

confidence: 99%

Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Wang

Yang

et al. 2022

BMC Infect Dis

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“…Penicillium is one of the most common fungi in the environment and is rarely a pathogen in humans. However, it has been increasingly recognized as an opportunistic pathogen in immunocompromised hosts, causing endophthalmitis [ 8 ], pulmonary infections [ 9 ], endocarditis [ 10 ], osteomyelitis [ 11 ], skin infections [ 12 ], and disseminated infections [ 13 ]. We present first case of severe pneumonia with pleural effusion caused by co-infection of P. variotii and P. oxalicum in a 56-year-old female with poorly controlled type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Severe pneumonia with pleural effusion caused by co-infection of Paecilomyces variotii and Penicillium oxalicum in a diabetic patient

Wang,

Chen,

Liang

et al. 2024

BMC Infect Dis

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Background paecilomyces and Penicillium are considered as rare opportunistic pathogens in immunocompromised hosts, and pneumonia caused by Paecilomyces and Penicillium is rare. In this study, we present first case of severe pneumonia with pleural effusion caused by co-infection of Paecilomyces variotii (P. variotii) and Penicillium oxalicum (P. oxalicum) in a 66-year-old female with poorly controlled type 2 diabetes. Case presentation A 56-year-old woman patient presented to hospital for nausea, poor appetite, and vomiting for one day. On the second day of admission, blood culture and renal puncture fluid culture grew multidrug-resistant Escherichia coli (imipenem/cilastatin sensitive), and she received combination therapy with imipenem/cilastatin (1 g, every 8 h) and vancomycin (0.5 g, every 12 h). On the fourth day, she developed symptoms of respiratory failure. Pulmonary computed tomography (CT) showed an increase in pneumonia compared to before, with minor pleural effusion on both sides. Two fungi were isolated repeatedly from BALF culture, which were confirmed as P. variotii and P. oxalicum by Internal transcribed spacer (ITS) sequencing. Her pleural effusion was completely absorbed, pneumonia symptoms have significantly improved and discharged with receiving liposomal amphotericin B treatment for four weeks. Conclusions It is worth noting that clinicians and laboratory personnel should not simply consider Paecilomyces and Penicillium species as contaminants, especially in immunocompromised patients. Early fungal identification and antifungal drug sensitivity are crucial for clinical drug selection and patient prognosis.

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Molecular characterization of a novel non-segmented double-stranded RNA mycovirus isolated from Penicillium citrinum strain RCEF7060

Huang

Wang

et al. 2022

Arch Virol

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Pulmonary infection with Penicillium citrinum in a patient with multiple myeloma

Cited by 9 publications

References 9 publications

Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection

Severe pneumonia with pleural effusion caused by co-infection of Paecilomyces variotii and Penicillium oxalicum in a diabetic patient

Molecular characterization of a novel non-segmented double-stranded RNA mycovirus isolated from Penicillium citrinum strain RCEF7060

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