Pulmonary function changes in diabetic lung

El-Azeem, I Amal Abd; Hamdy, Gehan; Amin, Mohamed; Rashad, Alaa

doi:10.1016/j.ejcdt.2013.07.006

Cited by 31 publications

(8 citation statements)

References 18 publications

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“…Previous investigations suggested that the lung could be a target organ of diabetes based on clinical findings, such as reduced vital capacity and total lung capacity in diabetic patients 12 , 13 . However, there was no experimental evidence at the cellular level to elucidate the effect of diabetes on the lung.…”

Section: Discussionmentioning

confidence: 99%

“…Although diabetes-induced complications have been demonstrated to affect multiple organs, the effects of diabetes on the lung are poorly characterized. A number of studies have found that individuals with either type 1 or type 2 diabetes present with pulmonary abnormalities, such as reduced forced vital capacity (FVC) and total lung capacity (TLC) 12 , 13 . Emerging evidence suggests that diabetes might affect the lung, in part through the induction of fibrotic changes in the tissue 14 – 17 ; however, the effects of diabetes on the phenotype of alveolar epithelial cells (AECs) and on the involved cellular signaling pathways are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways

Talakatta

Sarikhani

Muhamed

et al. 2018

Sci Rep

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In the long term, diabetes profoundly affects multiple organs, such as the kidney, heart, brain, liver, and eyes. The gradual loss of function in these vital organs contributes to mortality. Nonetheless, the effects of diabetes on the lung tissue are not well understood. Clinical and experimental data from our studies revealed that diabetes induces inflammatory and fibrotic changes in the lung. These changes were mediated by TGF-β-activated epithelial-to-mesenchymal transition (EMT) signaling pathways. Our studies also found that glucose restriction promoted mesenchymal-to-epithelial transition (MET) and substantially reversed inflammatory and fibrotic changes, suggesting that diabetes-induced EMT was mediated in part by the effects of hyperglycemia. Additionally, the persistent exposure of diabetic cells to high glucose concentrations (25 mM) promoted the upregulation of caveolin-1, N-cadherin, SIRT3, SIRT7 and lactate levels, suggesting that long-term diabetes may promote cell proliferation. Taken together, our results demonstrate for the first time that diabetes induces fibrotic changes in the lung via TGF-β1-activated EMT pathways and that elevated SMAD7 partially protects the lung during the initial stages of diabetes. These findings have implications for the management of patients with diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways

Talakatta

Sarikhani

Muhamed

et al. 2018

Sci Rep

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“…Restrictive lung disease in diabetes may develop from chronic low-grade tissue inflammation, microangiopathy, and accumulation of nonenzymatic pre-AGEs and AGEs [47–50]. We observed a significantly higher signal of MBL accumulated in the diabetic lung.…”

Section: Discussionmentioning

confidence: 64%

Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes

Axelgaard

Østergaard

Haxha

et al. 2017

Mediators of Inflammation

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Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway. In two recent animal studies, we have shown that autoreactivity of MBL is increased in the kidney in diabetic nephropathy. We hypothesize that long-term exposure to uncontrolled high blood glucose in diabetes may mediate formation of neoepitopes in several tissues and that MBL is able to recognize these structures and thus activate the lectin pathway. To test this hypothesis, we induced diabetes by injection of low-dose streptozotocin in MBL double-knockout (MBL/DKO) mice. Development of diabetes was followed by measurements of blood glucose and urine albumin-to-creatinine ratio. Fluorophore-labelled recombinant MBL was injected intravenously in diabetic and nondiabetic mice followed by ex vivo imaging of several organs. We observed that MBL accumulated in the heart, liver, brain, lung, pancreas, and intestines of diabetic mice. We furthermore detected increased systemic complement activation after administration of MBL, thus indicating MBL-mediated systemic complement activation in these animals. These new findings indicate a global role of MBL during late diabetes-mediated vascular complications in various tissues.

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“…7 No.1 Maret 2019ISSN: 23372337-585X (Printed) paru ini tetap terjadi setelah terdiagnosis diabetes. Mekanisme yang terlibat dalam keadaan resisten insulin berkontribusi terhadap penurunan fungsi paru (Litonjua et al, 2005;I. et al, 2013;Zineldin, Hasan and Al-Adl, 2015).…”

Section: Hasil Dan Pembahasanunclassified

Perbedaan Length of Stay (LOS) Pasien Diabetes Mellitus Berdasarkan Komplikasi Di RSUP Dr. Sardjito Yogyakarta

Salim¹,

Lubis²,

Sugeng

2019

JurnalMIKI

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Complications are the factors that determine the length of the day of treatment of diabetes mellitus patients in the hospital such as hypertension, stroke, coronary heart disease, cholesterol, obesity and others. This study aims to analyze differences in Length of Stay (LOS) of patients with diabetes mellitus based on complications in RSUP Dr. Sardjito Yogyakarta.This research is an analytic observational quantitative research with cross sectional design. The population is all people with diabetes mellitus from year 2011-2016 recorded in electronic medical record. All the population used as research sample that is as many as 1,554 people. Independent variables in this study were hypertension, nephropathy, neuropathy, obesity, CHD, stroke, and pulmonary TB. Dependent variable is Length of Stay or long treatment of diabetes mellitus patient. Data analysis was performed using Independent T test. Diabetes mellitus patients at RSUP Dr. Sardjito year 2011-2016 amounted to 1,554 people with a trend that tends to decline. Most patients were aged 56-63 years (27.86%). The incidence of diabetes mellitus is dominated by type 2 with the highest complications being hypertension, nephropathy, and neuropathy. Based on the result of statistical test, there is a significant difference between the average LOS between patients with diabetes mellitus who have hypertension complications with non-hypertensive (p-value = 0.00), neuropathy with non-neuropathy (p-value = 0.00), coronary heart disease with which is not coronary heart disease (p-value = 0.035), and stroke with non-stroke (p-value = 0.032). Conclusions: There is significant difference in mean LOS among patients with diabetes mellitus who have complications of hypertension, neuropathy, coronary heart disease, and stroke with no complications of the disease.

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Pulmonary function changes in diabetic lung

Cited by 31 publications

References 18 publications

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways

Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes

Perbedaan Length of Stay (LOS) Pasien Diabetes Mellitus Berdasarkan Komplikasi Di RSUP Dr. Sardjito Yogyakarta

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