Pulmonary Function and Cardiovascular Risk Factor Relationships in Black and in White Young Men and Women

Higgins, Millicent; Keller, Jacob B.; Wagenknecht, Lynne E.; Townsend, Mary C.; Sparrow, David; Jacobs, David R.; Hughes, Glenn H.

doi:10.1378/chest.99.2.315

Cited by 61 publications

(38 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Attention has been paid to the association of FEV1 with mortality, because this lung function parameter is more reproducible and less effort dependent than, for example, FVC and peak expiratory flow [40], and, moreover, it is considered to be the lung function variable that best predicts mortality [41]. Most previous studies of the association between lung function and mortality have used FEV1 % pred as the measure of lung function [13,21,41,42], although some studies have reported similar associations of FVC with CV mortality, for instance in the Framingham study [5], or assessed the association of peak expiratory flow with mortality [22,23].…”

Section: Discussionmentioning

confidence: 99%

Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males

Stavem¹

2005

European Respiratory Journal

115

View full text Add to dashboard Cite

Lung function has been associated with mortality after adjusting for other risk factors; however, few studies have adjusted for physical fitness and reported separate analyses according to smoking status.In 1972-1975, spirometry, clinical and physiological parameters were recorded in 1,623 apparently healthy males aged 40-59 yrs. After 26 yrs of follow-up, the current authors investigated the association between baseline lung function and mortality, adjusting for smoking, physical fitness and other potential factors.By 2000, 615 individuals (38%) had died, with 308 (50%) of these deaths from cardiovascular (CV) causes. Forced expiratory volume in one second was a predictor of all-cause mortality (risk ratio (RR) 1.10 per reduction of 10%) after adjusting for smoking, physical fitness, age, systolic blood pressure, body mass index and serum cholesterol. The corresponding multivariate RR was 1.07 for CV causes and 1.34 for respiratory death.In conclusion, in stratified analyses among current and former smokers, forced expiratory volume in one second % predicted was a strong independent predictor of all-cause mortality and respiratory death among current smokers. Forced expiratory volume in one second % predicted was not associated with mortality among never-smokers.

show abstract

Section: Discussionmentioning

confidence: 99%

Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males

Stavem¹

2005

European Respiratory Journal

115

View full text Add to dashboard Cite

show abstract

“…Cholesterol does not vary with lung function in normal subjects [55]. Most studies have not demonstrated significant differences in the prevalence of dyslipidemia between COPD patients and control subjects [56].…”

Section: Dyslipidemiamentioning

confidence: 96%

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel

Hurst

2011

Expert Review of Respiratory Medicine

134

108

View full text Add to dashboard Cite

“…Hyperlipidemia is a risk factor for atherosclerotic events, i.e., coronary heart disease, cerebral infarction and pulmonary infarction [1][2][3][4][5] . These patients often exhibit abnormal metabolism of lipids, including cholesterol, triglyceride (TG), phospholipids and cholesteryl esters [6] , so that measurement of lipoprotein classes, high density lipoprotein (HDL), low density lipoprotein (LDL), intermediate-density lipoprotein (IDL), very low density lipoprotein (VLDL), chylomicrons is clinically important.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Lipoprotein Peak x Eluted from a Column with the Eluent of High-magnesium Ion Concentration in Lipoprotein Analysis Using the Cation-exchange Chromatography

Hirowatari¹,

Yoshida²,

Ogura³

et al. 2005

American J. of Biochemistry and Biotechnology

View full text Add to dashboard Cite

Abstract:The new lipoprotein analysis method using a cation-exchange chromatography, which contains a sulfopropyl-ligand column and two magnesium ion-containing eluents was previously reported. This method can separate serum lipoproteins on the column gel with a magnesium ion concentration gradient and high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and an unspecified lipoprotein peak are eluted in order from the column. We have now characterized the unspecified lipoproteins, designated peak x, which is last eluted from the column with the eluent of high-magnesium ion concentration. The peak x was small size chylomicron fraction with a part of VLDL. Furthermore, the cholesterol values in the peak x were significantly correlated with remnant-like particle (RLP)-cholesterol values. The peak x separated from a hyperlipidemic patient included apolipoprotein B-100, B-48, E, A-1 and Cs (C-I, C-II, C-III) and its composition of free cholesterol, cholesteryl esters, triglyceride (TG) and phospholipids in total lipids were 6, 15, 66 and 13%, respectively. These results suggest that a major part of the lipoprotein peak X may be composed of remnants of chylomicron and VLDL, but it remains to be elucidated.

show abstract

Pulmonary Function and Cardiovascular Risk Factor Relationships in Black and in White Young Men and Women

Cited by 61 publications

References 16 publications

Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males

Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Characteristics of Lipoprotein Peak x Eluted from a Column with the Eluent of High-magnesium Ion Concentration in Lipoprotein Analysis Using the Cation-exchange Chromatography

Contact Info

Product

Resources

About