Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel, Anant; Hurst, John R.

doi:10.1586/ers.11.62

Cited by 134 publications

(122 citation statements)

References 92 publications

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“…In the literature, some cohorts have a very high prevalence of hypertension (63.4%), 19 whereas others, including ours (42%), are within the 40% to 60% range. [20][21][22] Our congestive heart failure estimate 15 ; similarly, we found cohort members with a "COPDother" comorbidity (490.x, bronchitis, not specifi ed as acute or chronic), at less risk of subsequent hospital admission. Interestingly, "substance-related disorders" comorbidity, although present in only a small percentage (1.5%, 512 of 33,799) of the cohort, had the largest association with increased subsequent hospital admission among the comorbidities we examined.…”

Section: Comorbiditiessupporting

confidence: 60%

Population-Based Burden of COPD-Related Visits in the ED

Yeatts

Lippmann

Waller

et al. 2013

Chest

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Section: Comorbiditiessupporting

confidence: 60%

Population-Based Burden of COPD-Related Visits in the ED

Yeatts

Lippmann

Waller

et al. 2013

Chest

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“…Furthermore, COPD patients with CVD, hypertension and T2DM were shown to be at increased risk for hospitalizations and all-cause mortality (4). The high MetS prevalence in lower disease stages coincides with the reported high cardiovascular-related mortality in mild to moderate disease (5). Furthermore, recent studies have identified a so called "co-morbidity predominant subtype" of COPD patients, which is characterized by a cluster of metabolic co-morbidities, including obesity, CVD and T2DM (43,44).…”

Section: Discussionmentioning

confidence: 57%

“…Previous research has indeed shown that both CVD and T2DM are frequent comorbidities in COPD (4,5). Furthermore, COPD patients with CVD, hypertension and T2DM were shown to be at increased risk for hospitalizations and all-cause mortality (4).…”

Section: Discussionmentioning

confidence: 99%

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The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Lipovec

Beijers

Borst

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

133

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Type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD). Prevention of these co-morbidities in COPD requires knowledge on their risk factors. Metabolic syndrome (MetS) predisposes to the development of T2DM and CVD but its prevalence in COPD remains unclear. The aim of this review was to assess the prevalence of MetS and its components in COPD patients compared to controls and to investigate the contribution of clinical characteristics to MetS prevalence. We systematically searched PubMed and EMBASE for original studies in COPD that have investigated the prevalence of MetS and its components. In total, 19 studies involving 4208 COPD patients were included. The pooled MetS prevalence was 34%. Compared to controls, the prevalence was higher in COPD (10 studies, 32% and 30%, p = 0.001). The three most prevalent components in both COPD and controls were arterial hypertension (56% and 51%), abdominal obesity (39% and 38%) and hyperglycemia (44% and 47%). Compared to COPD patients without MetS, those with MetS had higher body mass index (BMI) (29.9 and 24.6 kg/m 2 , p < 0.001), higher forced expiratory volume in 1 second (FEV 1 ) % predicted (54 and 51, p < 0.001) and were more frequently female (31% and 25%, p = 0.011). In conclusion, the prevalence of MetS in COPD patients is high and hypertension, abdominal obesity and hyperglycemia are the most prevalent components. Further studies are needed to evaluate the impact of lifestyle factors and medications on MetS in COPD.

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“…Примерно по тем же причинам мы отметили боль-шую частоту ХОБЛ у больных с ИМ (р<0,0001). Исходная гипоксия организма, которая встречается у всех больных при нарушении дыхательной функции легких, приводит к функционированию порочного круга: гипоксия -повы-шение сердечного выброса для компенсации тканевого газообмена -возрастание нагрузки на миокард -ише-мия миокарда -усиление гипоксии [3,10]. Стоит отме-тить, что гипертрофия миокарда встречается у 90% боль-ных со стабильным течением ХОБЛ [12].…”

Section: результаты и обсуждениеunclassified

Myocardial infarction after carotid endarterectomy

Kosenkov¹,

Виноградов²

2015

Kardiol. serdechno-sosud. khir.

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Introduction. Myocardial infarction is a severe complication after carotid endarterectomy. Searching for predictors of its development is actual problem of current cardiovascular surgery. Material and methods. The study included 1018 patients who underwent carotid endarterectomy. Postoperative myocardial infarction (MI) was diagnosed in 38 (3.7%) patients. These patients were included into study group. Control group enrolled 980 (96.3%) patients without MI. Results. Patients who had postoperative myocardial infarction were older (p = 0.005). Atrial fibrillation, chronic obstructive pulmonary disease (COPD) and severe arterial hypertension (p<0.0001) have been more frequently diagnosed in these group. At the same time they rarer received statins (p<0.0001) and beta-blockers (p=0.02). Correlation analysis revealed a relationship between myocardial infarction, COPD, atrial fibrillation, pulmonary hypertension and beta-blockers administration with development of postoperative acute myocardial infarction. Conclusion. Above-mentioned predictors of myocardial infarction should be considered before carotid arteries reconstruction to reduce incidence of this complication.

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Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Cited by 134 publications

References 92 publications

Population-Based Burden of COPD-Related Visits in the ED

Population-Based Burden of COPD-Related Visits in the ED

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Myocardial infarction after carotid endarterectomy

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