Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males

Abstract

Lung function has been associated with mortality after adjusting for other risk factors; however, few studies have adjusted for physical fitness and reported separate analyses according to smoking status.In 1972-1975, spirometry, clinical and physiological parameters were recorded in 1,623 apparently healthy males aged 40-59 yrs. After 26 yrs of follow-up, the current authors investigated the association between baseline lung function and mortality, adjusting for smoking, physical fitness and other potential factors.By 2000, 615 individuals (38%) had died, with 308 (50%) of these deaths from cardiovascular (CV) causes. Forced expiratory volume in one second was a predictor of all-cause mortality (risk ratio (RR) 1.10 per reduction of 10%) after adjusting for smoking, physical fitness, age, systolic blood pressure, body mass index and serum cholesterol. The corresponding multivariate RR was 1.07 for CV causes and 1.34 for respiratory death.In conclusion, in stratified analyses among current and former smokers, forced expiratory volume in one second % predicted was a strong independent predictor of all-cause mortality and respiratory death among current smokers. Forced expiratory volume in one second % predicted was not associated with mortality among never-smokers.

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

“…In American and European populations, FEV 1 /FVC ratio and mortality often present significant relationships (2,(12)(13)(14), but in this study, we found no such relationship. This could be related to ratio and mortality differences, in addition to various anthropo-biological, social and cultural differences between Japanese and non-Japanese population.…”

“…Impaired lung function is a significant predictor of mortality (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd.…”

“…However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd. (1,2,8).…”

Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study

“…Several studies observed an association between pulmonary function and cardiovascular events, even after correcting for confounders like smoking [16][17][18][19][20]. Forced expiratory volume in one second (FEV 1 ) is a robust accurate index reflecting pulmonary physiology and is associated with a higher risk of dying from cardiovascular conditions [17,18].…”

“…Forced expiratory volume in one second (FEV 1 ) is a robust accurate index reflecting pulmonary physiology and is associated with a higher risk of dying from cardiovascular conditions [17,18].…”