Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Todd, William U.; Benninghoff, G D O Michael; Frauenhoffer, Elizabeth E.; Zander, Dani S.

doi:10.1002/dc.21193

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…The histiocytes can even occupy the majority of a mass lesion, such that the lymphoproliferative disorder is not readily appreciated [27]. Our case illustrates the cytomorphology and histologic follow-up of a case of CSH in the breast associated with MZL, which is the first report of CSH in the breast, and one of a few reports of CSH in the cytology literature [21,22]. …”

Section: Discussionmentioning

confidence: 80%

“…The cytologic findings of CSH have not been well described in the cytology literature with only rare reports [21,22], and to the best of our knowledge, have not been described in the breast. This case illustrates the cytomorphology, histopathology, ancillary studies and differential diagnosis of CSH in a breast fine needle aspiration (FNA) associated with extranodal marginal zone lymphoma (MZL).…”

Section: Introductionmentioning

confidence: 79%

See 1 more Smart Citation

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Gao

Khalbuss²,

Austin³

2011

Acta Cytologica

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Crystal storing histiocytosis (CSH) is a very rare immunoglobulin (Ig) deposition disorder in which macrophages accumulate light chains or Ig crystalline inclusions. It is frequently associated with lymphoproliferative disorders, but can be seen in some reactive conditions too. This article reports the cytomorphologic, histopathologic, and ancillary study findings of a marginal zone B cell lymphoma of the breast with CSH in a 54-year-old woman. To the best of our knowledge, this is the first report describing CSH in the breast and one of a few reports describing the cytomorphology of CSH. In breast fine-needle aspiration biopsies, CSH can be confused with benign processes such as fat necrosis and histiocytic lesions. Thus, awareness of this rare entity and its frequent association with lymphoproliferative disorders is useful in order to triage a specimen appropriately and exclude the possibility of a lymphoproliferative process.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 79%

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Gao

Khalbuss²,

Austin³

2011

Acta Cytologica

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“…Numerous extranodal sites may be affected, but the lung is an uncommon site of involvement and is seen in only about 10% of patients with generalized disease. 1,2,[9][10][11][12][13][14][15][16] More than half of reported CSH patients have localized disease, and in these patients lung and pleura is second only to head and neck as a common site of presentation, accounting for 11 (24%) of 46 patients summarized by Dogan et al 1 Ten patients with pulmonary CSH previously described in the English language peer-reviewed literature presented in the sixth to seventh decades of life, with a mean age of 61.8 years (see Table). 4,7,[9][10][11][12][14][15][16][17] All presented with either solitary (7) or multiple (3) lung masses or nodules.…”

Section: Commentmentioning

confidence: 99%

“…An underlying lymphoproliferative or plasma cell disorder was documented in 7 patients. 4,[9][10][11][12]16,17 Three patients had no apparent lymphoproliferative disease. One patient had a longstanding history of rheumatoid arthritis, 14 and another was status posttreatment of tuberculosis with a persistent solitary lung nodule.…”

Section: Commentmentioning

confidence: 99%

Crystal-Storing Histiocytosis Complicating Primary Pulmonary Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

Zhang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Crystal-storing histiocytosis is an uncommon form of nonneoplastic histiocytic proliferation that in most patients complicates an underlying lymphoproliferative or plasma cell disorder. Lung is a common site of involvement in patients with localized disease. We present an illustrative example from a 54-year-old woman with an asymptomatic solitary lung nodule. The tumor was characterized by sheets of histiocytes with abundant cytoplasm expanded by distinctive eosinophilic inclusions. Focal necrosis was present. Aggregates of monocytoid lymphocytes and clusters of peribronchiolar plasma cells were overshadowed by the histiocytic infiltrate. Immunohistochemical stains showed CD68 staining in nonneoplastic histiocytes and CD20 staining in monocytoid lymphocytes. In situ hybridization studies showed κ light-chain restriction in plasma cells. These results, combined with the histologic findings, supported the diagnosis of crystal-storing histiocytosis complicating marginal zone lymphoma of mucosa-associated lymphoid tissue. We review the literature pertaining to pulmonary crystal-storing histiocytosis, highlighting the differential diagnosis for this rare phenomenon.

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“…Pulmonary involvement may be interstitial or nodular with pleura more rarely involved. Lesions are characterized by infiltration of histiocytic cells containing crystal deposits [209,210,211,212]. The underlying lymphoid B proliferation may remain occult [210].…”

Section: Other Diseases Due To Nonamyloid Iggsmentioning

confidence: 99%

The Lung in Dysregulated States of Humoral Immunity

Uzunhan¹,

Jeny²,

Kambouchner³

et al. 2017

Respiration

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In common variable immunodeficiency, lung manifestations are related to different mechanisms: recurrent pneumonias due to encapsulated bacteria responsible for diffuse bronchiectasis, diffuse infiltrative pneumonia with various patterns, and lymphomas, mostly B cell extranodal non-Hodgkin type. The diagnosis relies on significant serum Ig deficiency and the exclusion of any primary or secondary cause. Histopathology may be needed. Immunoglobulin (IgG) replacement is crucial to prevent infections and bronchiectasis. IgG4-related respiratory disease, often associated with extrapulmonary localizations, presents with solitary nodules or masses, diffuse interstitial lung diseases, bronchiolitis, lymphadenopathy, and pleural or pericardial involvement. Diagnosis relies on international criteria including serum IgG4 dosage and significantly increased IgG4/IgG plasma cells ratio in pathologically suggestive biopsy. Respiratory amyloidosis presents with tracheobronchial, nodular, and cystic or diffuse interstitial lung infiltration. Usually of AL (amyloid light chain) subtype, it may be localized or systemic, primary or secondary to a lymphoproliferative process. Very rare other diseases due to nonamyloid IgG deposits are described. Among the various lung manifestations of dysregulated states of humoral immunity, this article covers only those associated with the common variable immunodeficiency, IgG4-related disease, amyloidosis, and pulmonary light-chain deposition disease. Autoimmune connective-vascular tissue diseases or lymphoproliferative disorders are addressed in other chapters of this issue.

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Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Cited by 13 publications

References 21 publications

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Crystal-Storing Histiocytosis Complicating Primary Pulmonary Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

The Lung in Dysregulated States of Humoral Immunity

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